- In a mice experiment, researchers from Cold Spring Harbor Laboratory got an insight into the exact nature of the connection between cancer and psychological stress. The researchers discovered that stress hormones called glucocorticoids impacted the neutrophils (white blood cells), forming structures called NETs (neutrophil extracellular traps). Usually, NETs play a positive role in immune defense in the body, but “in cancer, NETs create a metastasis-friendly environment.” The study was published in Cancer Cell.
- Researchers at the University of Virginia Cancer Center identified a new, more efficient than existing methods, way to identify high-risk patients with acute myeloid leukemia. By measuring specific molecules in cancer cells, the new method helps identify patients at risk of poor outcomes and how well patients would respond to treatments. In the future, the technique may lead to more personalized treatments and better outcomes for patients with blood cancer. This research was published in Blood Advances.
- Researchers from UC San Francisco (UCSF) and Northwestern University borrowed from cancer stratagems to fight cancer by using a specific mutation found in lymphoma to drastically increase the potency of normal human T cells in killing cancer cells without triggering side effects. Also, while current immunotherapies are used only against hematological cancers, the T cells engineered by Northwestern U and UCSF could kill solid tumors – “tumors derived from skin, lung and stomach in mice.” Human trials can be expected in the future. An article reporting on this research was published in Nature.
- In a preclinical study, researchers from Columbia University and other institutions explored a molecule called Malat1, responsible for activating breast cancer dormant cells and triggering metastasis. By deleting the Malat1 gene, researchers were able to suppress cancer’s ability to metastasize. Extended to humans in the future, this research may eventually lead to better treatments and improved patient outcomes. The study was published in Nature Cancer.
- Researchers from Vanderbilt University developed a way to kill a tumor by “disrupting its acidic “microenvironment” without harming normal tissue”. The method targets hydroxyapatite (HAP), a naturally occurring mineral also produced by some tumors. The study was published in Cancer Medicine.
New eBook — Hematology: A Pathophysiologic Approach
The MSK Library now has access to the 2nd edition of Hematology: A Pathophysiologic Approach. This text offers information on hematopoiesis, immunology, hemostasis, hemoglobinopathy, metabolic disorders, genetics, and neoplasia.
Hematology: A Pathophysiologic Approach explains interrelationships between the diverse factors that can give rise to disease, covers a wide range of subjects, including platelets and coagulation, transfusion medicine, cytotoxic chemotherapy, infections, the immune system, and bone marrow transplantation, and shows how hematologic disorders are evaluated through blood counting, histopathology, immunohistochemistry, cytogenetics, and coagulation testing.
ClinicalKey eBooks are readable online; in order to download a PDF you will need to create a personal account with Elsevier/ClinicalKey. To register for a new account on ClinicalKey, click the “Register” link in the top right while on the ClinicalKey platform. Enter your name and MSKCC email on the registration form.
If you have any questions or issues, please email resources@mskcc.org
New eBook: Goldman-Cecil Medicine
The library has added the 27th edition of Goldman-Cecil Medicine to our collection. This text provides advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology.
Goldman-Cecil Medicine has a practical, templated organizational structure with an emphasis on up-to-date, evidence-based references. The 27th edition now includes more information on Population Health, Effects of Climate Change on Health, Bradycardias, Transgender Medicine, Whipple Disease, COVID-19 Virology and Pathobiology, COVID-19 Epidemiology/Clinical Manifestations/Diagnosis/Community Prevention, COVID-19 Treatment and Vaccination, Polyomaviruses, and more.
ClinicalKey eBooks are readable online; in order to download a PDF you will need to create a personal account with Elsevier/ClinicalKey. To register for a new account on ClinicalKey, click the “Register” link in the top right while on the ClinicalKey platform. Enter your name and MSKCC email on the registration form.
If you have any questions or issues, please email resources@mskcc.org