- Researchers from the University of Michigan found, in preclinical studies, that a low-protein diet blocked the nutrient signaling pathway that drove colon cancer growth. “A low-protein diet, and specifically a reduction in two key amino acids” starved cancer cells and helped overcome treatment resistance Results of the study were published in Gastroenterology.
- Researchers from the University of Missouri discovered that nicotinamide, or niacinamide, a form of vitamin B3, might increase breast cancer and brain metastasis risk. It is contrary to the results of earlier research that showed multiple health benefits of taking the supplement. The study was published in Biosensors and Bioelectronics.
- New animal research on squamous cell carcinoma (SCC), a skin cancer linked to RAS gene mutations, found that cancer development was driven by the interaction and mutual influence of tumor stem cells and their environment. The study further discovered a surprising for SCC connection to leptin, a hormone produced by fat cells. The findings of this study go beyond the studied cancer type and give an insight into cancer biology that may result in developing new ways of treating cancer. The study was published in Nature.
- Canadian researchers used mathematics to devise an algorithm for scheduling radiation therapy that could make it up to 22 percent more effective at killing cancer cells than existing standard radiation treatment regimens. The algorithm needs to be tested in clinical studies. The work was published in Journal of Mathematical Biology.
- Scientists from Germany discovered the reason for the previously observed phenomenon where metastatic growth only appeared after the surgical removal of the original tumor. They conducted an animal study and, in the cancer cells, identified a messenger substance (ANGPLT4) that promoted the local growth of the primary tumor. In the blood, ANGPLT4 split into two fragments, one of which suppressed metastasis. Surgical removal of the primary tumor disables the source of the metastasis-suppressing fragment, thus activating individual dormant metastatic tumor cells. While surgery remains the gold standard in treating most cancers, further study of ANGPLT4 may pave the way to developing new metastasis-suppressing drugs. The study was published in the Journal of Experimental Medicine.
It’s That Time of Year: Check Out the 2022 Highly Cited Researchers™
Clarivate released its 2022 list of Highly Cited Researchers™. Their methodology identifies approximately 7,000+ researchers from around the world who demonstrate significant influence in their field(s) of interest through their highly cited papers. Curious on who made this global list of influential scientific researchers from Memorial Sloan Kettering (MSK)? Read on to find out!
The Highly Cited Researchers’ names are drawn from the publications that rank in the top 1% by citations for field and publication year in the Web of Science™ citation index.
This year, I am delighted to share that 49 researchers associated with MSK made this prestigious list. Thirty-three MSK authors on the 2022 list were also on the 2021 list. In addition, Sarat Chandarlapaty, Alexander Drilon, Xuejun Jiang, and Ming O. Li were first time researchers to make the list.
| Name | Category | Name | Category |
| Omar Abdel-Wahab | Molecular Biology & Genetics | Vincent A. Miller | Clinical Medicine |
| Maria E. Arcila | Clinical Medicine | Robert J. Motzer | Clinical Medicine |
| Michael F. Berger | Clinical Medicine | *Eric G. Pamer | Immunology |
| *Renier Brentjens | Cross-Field | Dana Pe’er | Molecular Biology & Genetics |
| Margaret K. Callahan | Cross-Field | Michael A. Postow | Clinical Medicine |
| Sarat Chandarlapaty | Cross-Field | Natasha Rekhtman | Cross-Field |
| Justin R. Cross | Cross-Field | Gregory J. Riely | Clinical Medicine |
| Elisa de Stanchina | Cross-Field | Neal Rosen | Cross-Field |
| Luis A. Diaz, Jr. | Cross-Field | Jonathan Rosenberg | Cross-Field |
| Alexander Drilon | Clinical Medicine | Alexander Y. Rudensky | Immunology |
| Frederic Geissmann | Immunology | Charles M. Rudin | Clinical Medicine |
| *Asia Gobourne | Cross-Field | Michel Sadelain | Cross-Field |
| Mithat Gonen | Cross-Field | Charles L. Sawyers | Cross-Field |
| *Matthew D. Hellmann | Clinical Medicine | Howard I. Scher | Cross-Field |
| Clifford A. Hudis | Clinical Medicine | Nikolaus Schultz | Cross-Field |
| Christine A. Iacobuzio-Donahue | Molecular Biology & Genetics | *Alexandra Snyder | Cross-Field |
| Xuejun Jiang | Cross-Field | David Solit | Cross-Field |
| *David S. Klimstra | Cross-Field | Ying Taur | Cross-Field |
| Marc Ladanyi | Clinical Medicine | Craig B. Thompson | Molecular Biology & Genetics |
| *Jacob H. Levine | Cross-Field | William D. Travis | Clinical Medicine |
| Ross L. Levine | Cross-Field | Marcel R. M. van den Brink | Immunology |
| Ming O. Li | Cross-Field | Agnes Viale | Cross-Field |
| Joan Massague | Molecular Biology & Genetics | Jedd D. Wolchok | Immunology, Clinical Medicine |
| Ingo K. Mellinghoff | Cross-Field | *Ahmet Zehir | Cross-Field |
| Taha Merghoub | Cross-Field | * Former employee |
To see current and past researchers, check out Synapse, your portal to MSK works, containing a database of references for journal articles, books/chapters, conference papers, meeting abstracts, and other items published by MSK authors.
On behalf of the Library staff, congratulations to these researchers and to all of our distinguished authors, who through their work contribute daily to the ever-growing body of published medical and scientific literature.
Donna Gibson
Director, Library Services
Webinar: “Retractions Are on the Rise….But Not Enough”
The number of retractions has increased significantly in recent years. Fraudulent research impacts all researchers, their institutions, and the journals that have accepted their manuscripts for publication. Join us for an historical overview and insights from our speakers about the cost of scientific fraud and the retraction process.
In addition, there will be time for attendees to participate in an interactive Q&A session.
Date: Thursday, December 8, 2022
Time: 12:30 PM to 1:30 PM, EST
Location – Zoom Webinar – Register Now
Speakers:
Dr. Ivan Oransky, MD, Co-founder of Retraction Watch, Editor in Chief of Spectrum and distinguished Writer in Residence at New York University’s Arthur Carter Journalism Institute
Dr. Ivan Oransky was previously the President of the Association of Health Care Journalists and Vice President of editorial at Medscape. He has held editorial leadership positions at MedPage Today, Reuters Health, Scientific American and The Scientist. He is the recipient of the 2015 John P. McGovern Medal for excellence in biomedical communication from the American Medical Writers Association, and in 2017 was awarded an honorary doctorate in civil laws from The University of the South (Sewanee). In 2019, the judges for the John Maddox Prize, which promotes those who stand up for science in the face of hostility, gave him a commendation for his work at Retraction Watch.
Michael Streeter, Director of Research Integrity & Publishing Ethics at Wiley
Mike Streeter leads Wiley’s work in implementing best practices and policy for ethics and integrity in Wiley’s research portfolio; he champions quality and transparency in journals publishing. He has worked in academic publishing for the last seventeen years and through that experience recognizes the value of close collaboration and communication with our communities.