- Stress can re-ignite dormant tumor cells to cause cancer recurrence months or years after completing of successful treatment. A mixed animal and human study by an international group of researchers established that norepinephrine and cortisol, stress hormones released into the bloodstream when the level of stress is elevated, start a chain of biochemical events ultimately leading to reactivating the tumor cells. One of the findings in the human part of the study was the beta-blocker’ class of drugs ability to inhibit stress hormone signaling which prevented the reactivation of cancer cells. This finding opens up the possibility of beta-blockers use for cancer recurrence prevention. The study was published in Science Translational Medicine.
- Harvard’s Wyss Institute for Biologically Inspired Engineering and John A. Paulson School for Engineering and Applied Sciences (SEAS) used an unconventional approach to managing hard to treat lung metastases. They delivered immune system stimulating chemicals directly into the lung metastasis via drug-filled nanoparticles attached to red blood cells thus sparing the healthy lung tissues otherwise damaged by chemotherapy. The scientists also established that this method could halt further lung cancer growth and also prevent cancer recurrence. This animal research paves the way to new therapeutic options for metastatic cancers. The study was published in Nature Biomedical Engineering.
- Another team from Harvard’s Wyss Institute for Biologically Inspired Engineering and John A. Paulson School for Engineering and Applied Sciences (SEAS) developed a vaccine that combines chemo and immunotherapy in one injection. This animal research shows some promise even in difficult to treat cancers. The study was published in Nature Communications.
- Researchers at the Centre for Genomic Regulation (CRG) in Barcelona and Columbia University in New York City found a way to produce more hematopoietic stem cells (HSCs) – self-renewing stem cells crucial for treating cancer, as well as other serious diseases. The scarcity of such cells has always presented a problem. While these cells are typically derived from bone marrow and circulating and cord blood this research established another way of getting them – by reprogramming other blood stem cells. The researchers used a special algorithm to identify a gene capable of reprogramming blood stem cells to acquire hematopoietic stem cell properties. This research boosts the opportunity for more patients to benefit from hematopoietic stem cell treatments. The study was published in Cell Reports.
Advancing Authorship Webinar: Meeting the Challenges of Reproducibility
We are seeing in the published literature an increasing number of studies, editorials, and commentaries highlighting reproducibility and replication issues in scientific results. How are scientists addressing the reproducibility problem? Join us for a deep dive and thoughtful conversation on ways publishers, researchers, and educators, can contribute to the reproducibility crisis solution.
Date: Tuesday, December 15
Time: 12:00 PM – 1:30 PM
Location: Zoom Webinar – REGISTER NOW
Speakers/Panelists:
Daniel Evanko, PhD, Director of Journal Operations and Systems at the American Association for Cancer Research (AACR)
Dr. Evanko is the Director of Journal Operations and Systems at the AACR where he oversees the editorial operations of its nine research journals. Prior to that he was the Chief Editor of Nature Methods and later the Head of Editorial Services at Springer Nature. He has been heavily involved in efforts to improve the communication, transparency, and reproducibility of published scientific research for over 10 years.
Frances Weis-Garcia, PhD, Head of the Bi-Institutional Antibody and Bioresource Core Facility, Sloan Kettering Institute
Frances Weis-Garcia has headed the Bi-Institutional Antibody and Bioresource Core Facility for more than 20 years. She is past president of the Association of Biomolecular Resource Core Facilities, a professional society for those focused biomolecular technologies that make research possible. Frances earned her PhD from Weill Cornell Graduate School of Medical Sciences after conducting her thesis work at Memorial Sloan Kettering Cancer Center and performed her post-doctoral studies at the Rockefeller University.
Adrian Halme, PhD, Associate Professor, Department of Cell Biology, Assistant Dean for Graduate Research and Training, Biomedical Sciences Graduate Program, University of Virginia School of Medicine
Adrian Halme is an Associate Professor of Cell Biology and Assistant Dean for Graduate Research and Training at the University of Virginia School of Medicine. Adrian received his doctoral training in the lab of Dr. Gerry Fink at the Whitehead Institute at the Massachusetts Institute of Technology, and trained as a Postdoctoral Fellow with Dr. Iswar Hariharan at the University of California at Berkeley. Before taking his position as Assistant Dean, Adrian was the Assistant Director of the Advanced Microscopy Facility at the UVA School of Medicine, an experience which helped make him acutely aware of the issues of rigor and reproducibility as it applies to light imaging. In his role overseeing graduate and research training, he has been working to expand rigor and reproducibility training for graduate students including collaborating with Dr. Katie Sol-Church, director of the Genomics and Sequence Core at UVA to create “technical rotations” for first-year graduate students, where core-facility faculty would provide hands-on training in best practices for different research techniques. .
Andrew Vickers, PhD, Attending Research Methodologist, Epidemiology & Biostatistics, Memorial Sloan Kettering
Dr. Vickers’ research falls into three broad areas: randomized trials, surgical outcomes research and molecular marker studies. A particular focus of his work is the detection and initial treatment of prostate cancer. Dr Vickers has analyzed the ’learning curve’ for radical prostatectomy. He is working on a series of studies demonstrating that a single measure of prostate specific antigen (PSA) taken in middle age can predict lethal prostate cancer up to 30 years subsequently. He has also developed a statistical model to predict the result of prostate biopsy, work that has been commercialized and is clinically available through Opko Diagnostics. His work on randomized trials focuses on methods for integrating randomized trials into routine surgical practice so as to compare different approaches to surgery. As part of this work he has pioneered the use of web-interfaces for obtaining quality of life data from patients recovering from radical prostatectomy. Dr. Vickers’ methodological research centers primarily on novel methods for assessing the clinical value of predictive tools. In particular, he has developed decision-analytic tools that can be directly applied to a data set, without the need for data gathering on patient preferences or utilities. Dr Vickers has a strong interest in teaching statistics. He is course leader for the MSK biostatistics course and is author of the introductory textbook “What is a p-value anyway?” In his capacity as Co-Director of the PRO-CEL Core Facility, Dr. Vickers spearheads a number of innovative informatics initiatives throughout MSK, including the Amplio quality assurance system.
Clarivate Analytics Releases Their 2020 Highly Cited Researchers Report
Now in its seventh year, the 2020 Highly Cited Researchers Report from Clarivate Analytics (the company behind Web of Science) is now available. Scan the names below to find out who from Memorial Sloan Kettering made this global list of influential scientific researchers.
This year the report includes about 6,400 highly cited researchers (last year’s report included 6,216). The key findings have been summarized and to learn how a researcher makes this list, take a moment to review their methodology.
Name | Category | Name | Category |
---|---|---|---|
** Omar Abdel-Wahab | Molecular Biology & Genetics | ** Robert J. Motzer | Clinical Medicine |
** Maria E. Arcila | Clinical Medicine | ** Dana Pe’er | Cross-Field |
** Michael F. Berger | Clinical Medicine, Molecular Biology & Genetics | ** Michael A. Postow | Clinical Medicine |
** Cameron W. Brennan | Cross-Field | ** Victor E. Reuter | Cross-Field |
** Margaret K. Callahan | Cross-Field | ** Gregory J. Riely | Clinical Medicine |
** Timothy A. Chan | Cross-Field | ** Neal Rosen | Cross-Field |
** Justin R. Cross | Cross-Field | ** Alexander Y. Rudensky | Immunology |
** Elisa De Stanchina | Cross-Field | ** Charles M. Rudin | Clinical Medicine |
** Luis A. Diaz Jr. | Cross-Field | ** Michel Sadelain | Cross-Field |
Jianjiong Gao | Molecular Biology & Genetics | ** Leonard B. Saltz | Cross-Field |
** Frederic Geissmann | Immunology | ** Charles L. Sawyers | Cross-Field |
** Mithat Gonen | Cross-Field | ** Howard I. Scher | Clinical Medicine |
** Matthew D. Hellmann | Clinical Medicine | ** Nikolaus Schultz | Molecular Biology & Genetics |
** Clifford A. Hudis | Clinical Medicine | ** David B. Solit | Clinical Medicine |
David M. Hyman | Cross-Field | ** Martin S. Tallman | Clinical Medicine |
** Christine Iacobuzio-Donahue | Molecular Biology & Genetics | Ying Taur | Cross-Field |
** Cyriac Kandoth | Cross-Field | ** Craig B. Thompson | Molecular Biology & Genetics |
Philip W. Kantoff | Clinical Medicine | ** William D. Travis | Clinical Medicine |
** David S. Klimstra | Cross-Field | Robert R. Tuttle | Cross-Field |
** Mark G. Kris | Clinical Medicine | ** Marcel R. M. van den Brink | Cross-Field |
** Marc Ladanyi | Clinical Medicine, Molecular Biology & Genetics | ** Agnes Viale | Cross-Field |
** Ross L. Levine | Molecular Biology & Genetics | ** Jedd D. Wolchok | Clinical Medicine |
** Joan Massague | Molecular Biology & Genetics | Ahmet Zehir | Cross-Field |
** Taha Merghoub | Cross-Field | ||
** Vincent A. Miller | Clinical Medicine | ** was also cited on 2019 Report |
I am delighted to share that 48 MSK researchers made the 2020 list. On behalf of the library staff, congratulations to these researchers and to all of our distinguished authors, who through their work contribute daily to the ever-growing body of published medical and scientific literature.
Donna Gibson
Director of Library Services