Sound Waves to Fight Cancer, Nanoparticle Carrying Drugs and More

  • Researchers from the UC Davis Comprehensive Cancer Center identified a new way to trigger programmed cell death related to CD95 receptors. These protein receptors, also called Fas, are located on cell membranes and are instrumental in causing cell self-destruction. The research on new ways to trigger programmed cell death of tumor cells can lead to improved cancer treatments. The study was published in Cell Death & Differentiation.
  • In a preclinical study, researchers developed a new treatment for medulloblastoma, an aggressive brain cancer affecting mostly children. Researchers administered drug-carrying nanoparticles directly into the cerebrospinal fluid (CSF), thus overcoming existing challenges in delivering drugs in the CSF. The study was published in Science Translational Medicine.
  • U.S. researchers discovered the mechanism of how breast cancer cells may metastasize. The researchers showed that a motor protein, dynein, facilitated the movement of cancer cells in soft tissue models. This research paves the way for discovering new clinical targets against metastasis and has great potential for cancer treatment. The study was published in Advanced Science.
  • An international group of researchers is offering a “noninvasive alternative to surgery, chemotherapy and radiation treatments for cancer.” The U.S. Food and Drug Administration (FDA) has approved using targeted ultrasound waves, a technology called histotripsy, to fight cancer. The most recent study related to this research was published in Frontiers in Immunology.

Breast Cancer Awareness Month

October is Breast Cancer Awareness MonthIt’s the final day of Breast Cancer Awareness Month, a time when many MSK clinicians have been sharing their expertise with the media. Here is a selection of this month’s coverage:

Click here to learn more about breast cancer and MSK.

Intense Exercise in Lynch Syndrome patients and Cancer Risk

Exercise Oncology Research Program

A new study led by researchers at the University of Texas MD Anderson Cancer Center showed that forty-five minutes of intense exercise three times a week could decrease cancer risk in patients with Lynch Syndrome. Lynch syndrome is a genetic disorder that increases the risk of developing colorectal cancers.

The focus of the study was to investigate how exercising might help prevent cancer. Researchers found that the immune system was boosted in the exercise group, a factor most likely involved in cancer risk reduction.

This study was conducted with a small number of participants (21 patients). Further research is needed to confirm cancer risk reduction in this patient population and explore these findings for the general population.

The study was published in Clinical Cancer Research.