Tag Archives: reproducibility

Advancing Authorship Webinar: JoVE: Going Beyond Video

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Join us and learn more about JoVE’s publication process and why videos stand out as a viable approach to foster reproducibility, support training, and develop playlists that can be used as part of a customized course curriculum.

This session will review the publication and filming process, from start to finish and highlight new enhancements that go beyond just producing a video, such as the JoVE’s Methods Collections and new publication formats.

Special guest speakers include JoVE’s Global Scientific Advisor, JoVE’s Director of Editorial, and two staff members from Memorial Sloan Kettering – Assistant Laboratory Member and Associate Attending who will be sharing their recent experiences with this publisher.

Do not forget to bring your questions as there will be time for attendees to participate in an interactive Q&A discussion.

Date: Wednesday, December 6, 2023
Time: 12:00 PM to 1:00 PM, EST
Zoom Webinar: Register Now

Speakers’ Bios:

Thomas Karam, MSc, Global Scientific Advisor, JoVE obtained his degree in Biochemistry from the University of Portsmouth, producing a dissertation in the uses of stem cells in regenerative medicine. He then went on to obtain a master’s degree in Stem Cells and Regenerative Therapies: From Bench to Market, from King’s College London. His masters focused on creating a novel cell therapy using stem cells, with a focus on ameliorating the pathological effects of late onset Alzheimer’s disease. Tom joined JoVE as a Scientific Advisor and now works with research institutions/companies and universities all around the world.

Manu Jain, MD, Associate Attending, Department of Dermatology, Memorial Sloan Kettering Cancer Center, is a trained pathologist and specializes in the ground-breaking field of non-invasive optical in vivo and ex vivo imaging including multiphoton microscopy (MPM), confocal microscopy, optical coherence tomography (OCT), and full-field optical coherence tomography (FFOCT). Dr. Jain uses these devices to noninvasively guide the diagnosis and management of patients with skin cancers. She has extensively published in this field and has been an invited speaker in multiple National and International meetings. She is the Director of the Annual CME-accredited Confocal Microscopy course at MS, the co-founder and Vice-President of the Noninvasive Skin Imaging group of the Americas (NISIA), and a founding member of the Cutaneous Imaging Expert Resource Group of AAD. Dr. Jain serves as a Program Committee Member in the Dermatology and Plastic Surgery conference of the renowned Annual SPIE Photonics conference and was a past Secretary of the International Society of Teledermatology.

Ron Myers, PhD, Director of Editorial, JoVE  obtained his PhD from Tufts University in cellular, molecular, and developmental biology where he used various biochemical techniques including immunohistochemistry, RT-PCR, western blotting, ELISA, cell proliferation and migration assays, immunocytochemistry, as well as in situ zymography. Using these tools, his work involved assessing the expression of CCN5, a key matricellular protein, in the context of mouse embryonic development, as well as in the investigation of molecular pathways underlying this protein’s function in rat vascular smooth muscle cells. Following the completion of his graduate research in 2010, he continued his work at Tufts as a postdoctoral fellow, where he used various confocal microscopy techniques in order to study both morphology and action of dynamic subcellular structures known as podosomes. In 2011, he pursued a new postdoctoral fellowship at the Brigham and Women’s Hospital, an affiliate of Harvard Medical School, where he studied arrestin proteins and their interactions with various G protein-coupled receptors in the context of fructose metabolism. In 2015, he joined the editorial team at the Journal of Visualized Experiments (JoVE), where he worked as a Scientific Editor until early 2020. The Editor position consisted of acquiring scientific articles (with a special focus on Neuroscience and Cancer Research) highlighting cutting edge research and techniques for the journal. At the beginning of 2020, he moved on to the Director of Editor position at JoVE, leading a team of approximately 20 Editors, and other employees with the common goal of recruiting high-quality content for the journal. He also coordinated interaction between the Editorial department and various other departments at JoVE including the Peer Review department, IT department, and Video Production department.

Fabio Vanoli, PhD, Assistant Laboratory Member, The Cristina Antonescu Lab, Memorial Hospital Research Laboratories, Memorial Sloan Kettering Cancer Center has a longstanding interest in the study of DNA double strand break (DSB) repair mechanisms. As a graduate student, he used the model system Saccharomyces cerevisiae to investigate the role of DNA repair pathways in response to treatment with a class I histone deacetylases inhibitor, valproic acid (VPA). Results from this work showed that HDAC inhibition destabilizes the response to DSB through an autophagic pathway, suggesting a possible use of HDAC inhibitor in combination regimens with cytotoxic chemotherapy. During his postdoctoral training he focused his research on the identification of genotoxic effects, in normal human and murine cell lines, associated with PARP inhibitor treatment. Using different approaches, he discovered that short treatment with PARP inhibitor is sufficient to cause genomic instability as demonstrated by the increase in duplication events and in the formation of translocation. Using the CRISPR-Cas9 technology combined with homology directed repair (HDR), he also developed a method for the efficient recovery of cell lines harboring cancer relevant chromosomal translocation with inducible expression of fusions. These models are currently being used to study the molecular mechanisms leading to tumorigenesis and to identify clinically relevant targets for the treatment of those tumors. Fabio Vanoli is the course director for the Multi-Institutional Responsible Conduct of Research (RCR) program sponsored by MSK, Weill Cornell Medicine, Rockefeller University, and Hospital for Special Surgery. He is an Associate Director in Compliance and Internal Audit. Previously, he was an Assistant Lab Member (Assistant Attending Biologist) at MSK, with a research interest in prostate cancer.

Advancing Authorship Webinar: Meeting the Challenges of Reproducibility

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We are seeing in the published literature an increasing number of studies, editorials, and commentaries highlighting reproducibility and replication issues in scientific results. How are scientists addressing the reproducibility problem? Join us for a deep dive and thoughtful conversation on ways publishers, researchers, and educators, can contribute to the reproducibility crisis solution.

Date: Tuesday, December 15
Time: 12:00 PM – 1:30 PM
Location: Zoom Webinar – REGISTER NOW


Speakers/Panelists:

Daniel Evanko, PhD, Director of Journal Operations and Systems at the American Association for Cancer Research (AACR)

Dr. Evanko is the Director of Journal Operations and Systems at the AACR where he oversees the editorial operations of its nine research journals. Prior to that he was the Chief Editor of Nature Methods and later the Head of Editorial Services at Springer Nature. He has been heavily involved in efforts to improve the communication, transparency, and reproducibility of published scientific research for over 10 years.

Frances Weis-Garcia, PhD, Head of the Bi-Institutional Antibody and Bioresource Core Facility, Sloan Kettering Institute

Frances Weis-Garcia has headed the Bi-Institutional Antibody and Bioresource Core Facility for more than 20 years. She is past president of the Association of Biomolecular Resource Core Facilities, a professional society for those focused biomolecular technologies that make research possible. Frances earned her PhD from Weill Cornell Graduate School of Medical Sciences after conducting her thesis work at Memorial Sloan Kettering Cancer Center and performed her post-doctoral studies at the Rockefeller University.

Adrian Halme, PhD, Associate Professor, Department of Cell Biology, Assistant Dean for Graduate Research and Training, Biomedical Sciences Graduate Program, University of Virginia School of Medicine

Adrian Halme is an Associate Professor of Cell Biology and Assistant Dean for Graduate Research and Training at the University of Virginia School of Medicine. Adrian received his doctoral training in the lab of Dr. Gerry Fink at the Whitehead Institute at the Massachusetts Institute of Technology, and trained as a Postdoctoral Fellow with Dr. Iswar Hariharan at the University of California at Berkeley. Before taking his position as Assistant Dean, Adrian was the Assistant Director of the Advanced Microscopy Facility at the UVA School of Medicine, an experience which helped make him acutely aware of the issues of rigor and reproducibility as it applies to light imaging. In his role overseeing graduate and research training, he has been working to expand rigor and reproducibility training for graduate students including collaborating with Dr. Katie Sol-Church, director of the Genomics and Sequence Core at UVA to create “technical rotations” for first-year graduate students, where core-facility faculty would provide hands-on training in best practices for different research techniques. .

Andrew Vickers, PhD, Attending Research Methodologist, Epidemiology & Biostatistics, Memorial Sloan Kettering

Dr. Vickers’ research falls into three broad areas: randomized trials, surgical outcomes research and molecular marker studies. A particular focus of his work is the detection and initial treatment of prostate cancer. Dr Vickers has analyzed the ’learning curve’ for radical prostatectomy. He is working on a series of studies demonstrating that a single measure of prostate specific antigen (PSA) taken in middle age can predict lethal prostate cancer up to 30 years subsequently. He has also developed a statistical model to predict the result of prostate biopsy, work that has been commercialized and is clinically available through Opko Diagnostics. His work on randomized trials focuses on methods for integrating randomized trials into routine surgical practice so as to compare different approaches to surgery. As part of this work he has pioneered the use of web-interfaces for obtaining quality of life data from patients recovering from radical prostatectomy. Dr. Vickers’ methodological research centers primarily on novel methods for assessing the clinical value of predictive tools. In particular, he has developed decision-analytic tools that can be directly applied to a data set, without the need for data gathering on patient preferences or utilities. Dr Vickers has a strong interest in teaching statistics. He is course leader for the MSK biostatistics course and is author of the introductory textbook “What is a p-value anyway?” In his capacity as Co-Director of the PRO-CEL Core Facility, Dr. Vickers spearheads a number of innovative informatics initiatives throughout MSK, including the Amplio quality assurance system.