Nursing home residents with breast cancer should consider their overall health before consenting to surgery, concludes a new study in JAMA Surgery. The study reviewed records of nearly 6,000 female nursing home patients who received inpatient breast cancer surgery from 2003–2013. More than half of these residents had cognitive or functional impairments prior to surgery. The death rate of the residents was much higher than average: 30.9 percent died within the year following surgery, a significant increase from the 25 percent nursing home mortality rate. Of those who survived, 58.3 percent experienced a functional decline in the year following surgery. In reporting the study, Liz Szabo of Kaiser Health News spoke to MSK’s Dr. Deborah Korenstein, who found the increased death rate particularly noteworthy as breast surgery is generally considered low risk.
Category Archives: In the News
Hot Topics in Skin Cancer Research and Treatment
Two recent articles about skin cancer feature MSK researchers.
The first, The Atlantic piece “AI-Driven Dermatology Could Leave Dark-Skinned Patients Behind,” discusses how researchers need to diversify the skin colors represented in image repositories being used to develop machine-learning algorithms that identify cancerous skin lesions. MSK dermatologist Dr. Allan C. Halpern states that the International Skin Imaging Collaboration, for which he is a spokesperson, is working to do just that.
The second, The New York Times article, “Immunotherapy Drugs Slow Skin Cancer That Has Spread to the Brain,” describes a recent study of 94 melanoma patients with tumors that spread to their brains. It found that two immunotherapy treatments given in combination, ipilimumab and nivolumab, reduced tumor size and prolonged life for many of the patients. The article quotes MSK’s Dr. Jedd Wolchok, who has already applied the findings to treating his own patients.
Do “Zombie” Genes Help Fend Off Cancer in Elephants?
A new study led by researchers at the University of Chicago offers insight on how a “zombie” gene plays a key role in protecting elephants and other large animals from developing cancer. “Peto’s Paradox”, the lack of correlation between body size and cancer risk has intrigued and confounded cancer researchers for decades. In basic terms, big animals (think elephants, blue whales) should equal more cancer, simply because their bodies contain more cells and undergo more cell divisions.
Slower metabolic rates and slower growing tumors may play a role, but the University of Chicago researchers point to another factor – extra “zombie” LIF genes, including LIF6 (a leukemia inhibiting factor pseudogene), which is up-regulated by the master tumor suppressor gene p53 in response to DNA damage. When activated by p53 these “zombie” genes respond to damaged DNA by killing the cell.