Young Patients Often Face Misdiagnoses When it Comes to Colon Cancer

Many younger patients see more than one doctor and face misdiagnoses before being given a diagnosis of colorectal cancer (CRC), according to recent research presented during a webcast ahead of the 2019 AACR Annual Meeting.

Researchers reviewed 1195 online surveys completed by individuals who were diagnosed with CRC before the age of 50 and found that 57% were diagnosed between the ages of 40 and 49; 33% were diagnosed between 30 and 39; and only 10% were diagnosed before the age of 30. Thirty percent had a family history of CRC and 8% were diagnosed with Lynch syndrome, which can be a genetic predisposition to the disease.

The majority of these younger patients (70%) were diagnosed with stage III or stage IV disease – a contrast to their older counterparts, who are more likely to be diagnosed at stage I or II disease, according to the researchers.

The researchers attribute this difference to lack of awareness and misdiagnosis, as over 60% of these patients waited over a year to see a doctor, and 67% of these patients saw at least two doctors before their diagnosis.

March is Colorectal Cancer Awareness Month. Learn more about how MSKCC is fighting colon cancer. The Infographic on this post is courtesy of the National Cancer Institute.

Combination Chemotherapy Shows Promise in Post-Surgical Pancreatic Cancer Patients

A recent New England Journal of Medicine study indicates that post-surgical combination chemotherapy is more effective in patients with metastatic pancreatic cancer than the standard chemotherapy regimen. Researchers in Canada and France administered the combination chemotherapy, a modified FOLFIRINOX regimen, to 238 randomly selected eligible study participants and compared their outcomes to 243 participants receiving the standard post-surgical treatment, gemcitabine. On average, patients in the FOLFIRINOX group had 21.6 months of disease-free survival compared to 12.8 months in the gemcitabine group. In an Oncology Times article, MSK’s Dr. Alice Wei calls the study “practice changing.” The article notes that the chemotherapy regimen is not suitable for all pancreatic cancer patients, and that the combination chemotherapy can have more side effects.

Patient-controlled Mammography Compression Does Not Reduce Image Quality, Study Finds

A new study in JAMA Internal Medicine found that when women controlled the level of breast compression during mammography, image quality was not compromised. A French team studied 548 women, 275 of whom had mammography with self compression and 273 had standard mammography. Self-reported pain was lower in those with self compression, who only had an average three millimeter difference in compression compared to those with the standard test. In a Reuters Health report of the study, MSK’s Dr. Deborah Korenstein said that when women control compression, they may have more comfortable tests and be less likely to avoid mammograms in the future.