Pubmed Filters that are MeSH

In PubMed you can use Filters (sometimes referred to as Limits), located on the left hand side of the search results screen to limit your search by certain criteria. The Filters fall into several categories, such as Article Types, Article Language, etc. Some are visible on the search results screen by default, and some can be found and made visible for the future use when clicking Additional Filters button.

The Filters are efficient and handy tools for refining a search, adding desired criteria to your search terms, thus significantly increasing search precision.

However, users may not be aware of the fact that most of the Filters are, in fact, MeSH (Medical Subject Headings) terms set up as clickable Filters but functioning as MeSH terms behind the scenes. For example, if you apply a Clinical Trial Filter, your move will be translated by PubMed as adding a search term “clinical trial”[Publication Type] to your search strategy with an “AND” Boolean Operator, e.g. cancer AND “clinical trial”[Publication Type], Publication Type is a category in the MeSH tree.

Of course, if you are a proficient searcher you can type “clinical trial”[pt], instead of clicking the Filter button which just supports refining your search in an easy and visual way.

Filters are a great feature, however there is a caveat. When you apply a Filter that is a MeSH, your search will automatically be limited to Medline portion of Pubmed. Pubmed is comprised of Medline, as well as many open access articles (mostly coming from Pubmed Central) not indexed for Medline.

To efficiently search Pubmed in it’s entirety, you must construct your search strategy as a combination of MeSH and keywords. MeSH are assigned only to Medline references and there is some lag time in this process. When applying Filters that are based on MeSH to your search it will not retrieve these references only found outside of Medline, as well as some recent Medline references not yet assigned MeSH.

In other words, by using such Filters you limit your search results to Medline only (excluding some very recent references not yet assigned MeSH) instead of getting all Pubmed search results.

The Filter categories that are MeSH terms include:

  • Article Type (publication type)
  • Species
  • Sex
  • Age

These filters should be used with caution.

The non-MeSH Filters are safe to use in any search, including:

  • Text Availability
  • Associated Data
  • Publication Date
  • Article Language

In conclusion, it is possible to combine applying Filters with using appropriate search terms if you aim at limiting your search by some criteria, yet searching all of PubMed, but as this requires search proficiency it would be best to get assistance at your Library.


Vitamin D Supplements and Cancer, Interrupting Cancer Treatment to Have a Child and More

  • MIT scientists developed a novel method to introduce certain cancer-related mutations into mouse models. CRISPR genome-editing technology has been used to “design models of multiple mutations of the cancer-causing gene, Kras, in various organs.” The novel method is quite revolutionary, and much more efficient than the traditional labor- and time-consuming approach. The study was published in Nature Biotechnology.
  • Researchers from German Cancer Research Center and other institutions worldwide conducted a systematic review and meta-analysis on vitamin D3 supplementation impact on mortality and prognosis in cancer, which showed that taking vitamin D daily could help in reducing cancer death risk by 12%. The same review demonstrated that older people benefit more from taking the vitamin than younger people and that it works best when taken preventatively. The systematic review was published in Ageing Research Reviews.
  • While breast density was long linked to breast cancer risk, the new study demonstrated that the slower pace of changes in breast density in one breast compared to the other breast in the same patient over time also seems to be linked to cancer risk. The study was published in JAMA Oncology.
  • A new study demonstrated that interrupting a standard hormone therapy, given to prevent breast cancer recurrence, for conceiving a child “appears safe in the short term.” The study was published in the New England Journal of Medicine

Coming Changes to ClinicalTrials.gov Website

A new installment in the ongoing project of modernizing ClinicalTrials.gov – the largest database of currently funded clinical studies in the world – will be made in June of this year.

The current ClinicalTrials.gov website will be replaced with the modernized one which will have a new look and feel and better functionality. The users will have a better way of searching, viewing, and downloading information about clinical trials.

The National Library of Medicine announcement includes information about registration for the information session about the coming change that will be offered on April 25 and provides a glimpse into more innovations that are in the pipeline.