Pubmed Prompts on Errors in your Searches

When conducting searches in Pubmed, a searcher may make errors, either by omission or by mistyping. In many cases (but not all) Pubmed alerts you to the error and helps you identify it.

When are you alerted to an error?

Sometimes, it happens that a searcher omits one of a pair of parentheses or double quotes, which may result in the search done not as you’ve intended and producing different results. If you made such an error, the “first line of defense” that Pubmed offers would be a message that appears right above the search results.

For example, your intended search strategy was: “lung carcinogenesis” AND (cell* OR molecular)
Instead, you typed “lung carcinogenesis AND cell* OR molecular). In that case you will see, right above the search results: The following terms were ignored: “, )

The “second line of defense” could be found in Advanced Search. Details next to your Query in Advanced Search always display how your Query, or the exact search strategy you entered in the search box, was “translated” by Pubmed, i.e. what was actually processed and searched upon. So, when trying to get more details about the error and the exact place in the search where the error has occurred (especially in the case of complex and lengthy search strategies) you can go to Advanced Search and look at the Details for the search Query in question. A red Warnings icon with an Exclamation Mark would alert you to the problems and by clicking the caret symbol next to it you will see the unmatched quotes and parentheses in red in the search you entered.

Another example: you are searching with the keyword “breast” in the title or abstract fields of the Pubmed record but instead of breast[tiab], where [tiab] is a combined title/abstract field, you mistyped it as breast[taib]. You will see the following message above the search results Unknown field was ignored: [taib] and in the Advanced Search>Details you will see more details related to how Pubmed “translated” your search strategy, as shown below:

In some cases, when you enclose a phrase in double quotes intending to find references that include exactly same phrase, Pubmed actually does not find such references despite the fact that some of them do exist. That’s because Pubmed does not index all phrases and in this it differs from other databases, such as Embase, Scopus, etc. For example, if you type “chemoradiotherapy side effect*” you will be alerted by Pubmed that Quoted phrase not found: “chemoradiotherapy side effect*”. In fact, such references may be present in Pubmed but the search for this exact phrase will be “translated” by Pubmed as a broader query. Pubmed would parse the phrase and search on its components combining them with a Boolean Operator “AND”, behind the scenes. The details of how it was done can be found in Advanced Search>Details.

When are you not alerted to an error?

There are some instances where your error by omission or mistyping may go undetected. If your search includes the Boolean operator “OR” and you omitted it in error, Pubmed will not alert you to it. That’s because a space (in place of the “OR” that you’ve omitted) is treated by Pubmed as a Boolean Operator “AND”. So, your search will produce totally different results, but the error will go unnoticed.

Also, if you mistyped but the term you entered in error is still a legitimate term Pubmed would not detect anything as incorrect. In the first example, if you omit an asterisk in the keyword cell*, where the asterisk was used for truncation, allowing retrieval of references with words with different endings (e.g. cell, cells, cellular), Pubmed will process the search without noticing your error as the noun cell is a legitimate term.

Of course, if you made an error not by omission or mistyping but because of the lack of expertise, e.g. you incorrectly used an “AND” operator or a space instead of an “OR” between the terms in the same category or synonyms, Pubmed will not detect this error either. The takeaway for minimizing the chance of making such an error is taking a Library Pubmed class or, if you feel that the search results are not what you expected, consulting a Research Informationist at the Memorial Sloan Kettering Cancer Center Library.

Changes Coming to Pubmed’s My NCBI Account Sign In

Experienced Pubmed users are enjoying the convenience of saving their search strategies and search results to their personal My NCBI accounts. We have promoted the use of these accounts and explained their features in previous blog posts.

In June 2021 the change will come to how the users log in to their personal My NCBI account. The National Library of Medicine stated its concern for user privacy as the reason for the coming change. The users will no longer be able to log in their My NCBI account with their “NCBI-managed credentials”, i.e. username and password they created specifically for MY NCBI account access.

The detailed instruction on how to change the way you log in to My NCBI using your linked accounts such as Google (your gmail credentials) and their credentials (called “federated account credentials”) can be found in the National Library of Medicine publication called NLM Technical Bulletin.

Once you have linked your account you can then log in to My NCBI using the linked account credentials. Click on Log In button in the right upper corner on the Pubmed page

and you will be prompted with a screen similar to the one below (depending on what account you would choose to link):

Enjoy using My NCBI!

Stress Linked to Cancer Recurrence, Lung Cancer Metastasis Management and More

  • Stress can re-ignite dormant tumor cells to cause cancer recurrence months or years after completing of successful treatment. A mixed animal and human study by an international group of researchers established that norepinephrine and cortisol, stress hormones released into the bloodstream when the level of stress is elevated, start a chain of biochemical events ultimately leading to reactivating the tumor cells. One of the findings in the human part of the study was the beta-blocker’ class of drugs ability to inhibit stress hormone signaling which prevented the reactivation of cancer cells. This finding opens up the possibility of beta-blockers use for cancer recurrence prevention. The study was published in Science Translational Medicine.
  • Harvard’s Wyss Institute for Biologically Inspired Engineering and John A. Paulson School for Engineering and Applied Sciences (SEAS) used an unconventional approach to managing hard to treat lung metastases. They delivered immune system stimulating chemicals directly into the lung metastasis via drug-filled nanoparticles attached to red blood cells thus sparing the healthy lung tissues otherwise damaged by chemotherapy. The scientists also established that this method could halt further lung cancer growth and also prevent cancer recurrence. This animal research paves the way to new therapeutic options for metastatic cancers. The study was published in Nature Biomedical Engineering.
  • Another team from Harvard’s Wyss Institute for Biologically Inspired Engineering and John A. Paulson School for Engineering and Applied Sciences (SEAS) developed a vaccine that combines chemo and immunotherapy in one injection. This animal research shows some promise even in difficult to treat cancers. The study was published in Nature Communications.
  • Researchers at the Centre for Genomic Regulation (CRG) in Barcelona and Columbia University in New York City found a way to produce more hematopoietic stem cells (HSCs) – self-renewing stem cells crucial for treating cancer, as well as other serious diseases. The scarcity of such cells has always presented a problem. While these cells are typically derived from bone marrow and circulating and cord blood this research established another way of getting them – by reprogramming other blood stem cells. The researchers used a special algorithm to identify a gene capable of reprogramming blood stem cells to acquire hematopoietic stem cell properties. This research boosts the opportunity for more patients to benefit from hematopoietic stem cell treatments. The study was published in Cell Reports.