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2016-10-03

Fig 2. TANGO1 binding site located by X-ray crystallography.

Fig 2. TANGO1 binding site located by X-ray crystallography.
  • Ma W, Goldberg J

  • Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10061-6.

2016-10-04

Fig 3. Stripped sequence libraries facilitate MS/MS analysis of large proteomes.

Fig 3. Stripped sequence libraries facilitate MS/MS analysis of large proteomes.
  • Lycette BE, Glickman JW, Roth SJ, Cram AE, Kim TH, Krizanc D, Weir MP

  • J Proteome Res. 2016 Sep 2;15(9):2891-9.

2016-10-05

Fig 1. Venn diagrams depicting number and percent of patients with local, lymph node (LN) and distant recurrence at first evidence of recurrence (A) or overall during follow-up. Seventeen patients (22%) did not recur during follow-up.

Fig 1. Venn diagrams depicting number and percent of patients with local, lymph node (LN) and distant recurrence at first evidence of recurrence (A) or overall during follow-up. Seventeen patients (22%) did not recur during follow-up.
  • Samstein RM, Carvajal RD, Postow MA, Callahan MK, Shoushtari AN, Patel SG, Lee NY, Barker CA

  • Head Neck. 2016 Sep;38(9):1310-7.

2016-10-06

Fig 1. Spongiotic dermatitis.

Fig 1. Spongiotic dermatitis.
  • Ardigo M, Longo C, Gonzalez S

  • Br J Dermatol. 2016 Aug;175(2):364-74.

2016-10-07

Fig 1. Schematic of next-generation sequencing and ctDNA analyses.

Fig 1. Schematic of next-generation sequencing and ctDNA analyses.
  • Sausen M, Phallen J, Adleff V, Jones S, Leary RJ, Barrett MT, Anagnostou V, Parpart-Li S, Murphy D, Kay Li Q, Hruban CA, Scharpf R, White JR, O'Dwyer PJ, Allen PJ, Eshleman JR, Thompson CB, Klimstra DS, Linehan DC, Maitra A, Hruban RH, Diaz LA Jr, Von Hoff DD, Johansen JS, Drebin JA, Velculescu VE.

  • Nat Commun. 2015 Jul 7;6:7686.
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2016-10-10

Fig 3. Fecal metabolites are altered by celecoxib in APCMin/+ and WT mice.

Fig 3. Fecal metabolites are altered by celecoxib in APCMin/+ and WT mice.
  • Montrose DC, Zhou XK, McNally EM, Sue E, Yantiss RK, Gross SS, Leve ND, Karoly ED, Suen CS, Ling L, Benezra R, Pamer EG, Dannenberg AJ

  • Cancer Prev Res (Phila). 2016 Sep;9(9):721-31.

2016-10-12

Fig 5. Characterization of the response of mTOR-activating mutants to RAPTOR-mediated inhibition; mTOR kinase domain mutants exhibit increased kinase activity and display structural reorganization.

Fig 5. Characterization of the response of mTOR-activating mutants to RAPTOR-mediated inhibition; mTOR kinase domain mutants exhibit increased kinase activity and display structural reorganization.
  • Xu J, Pham CG, Albanese SK, Dong Y, Oyama T, Lee CH, Rodrik-Outmezguine V, Yao Z, Han S, Chen D, Parton DL, Chodera JD, Rosen N, Cheng EH, Hsieh JJ

  • J Clin Invest. 2016 Sep 1;126(9):3526-40
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2016-10-13

Fig 1. Advanced imaging for high-content biopsy (HCBx) and molecular phenotyping.

Fig 1. Advanced imaging for high-content biopsy (HCBx) and molecular phenotyping.
  • Weissleder R, Schwaiger MC, Gambhir SS, Hricak H

  • Sci Transl Med. 2016 Sep 7;8(355):355ps16.

2016-10-14

Fig 3.  Genomic Hallmarks of Thyroid Cancer along the Spectrum of Disease Progression.

Fig 3. Genomic Hallmarks of Thyroid Cancer along the Spectrum of Disease Progression.
  • Fagin JA, Wells Jr SA

  • N Engl J Med. 2016 Sep 15;375(11):1054-67.

2016-10-17

Fig 1. Delay time (Tdelay) was optimized between start of 4D-CT acquisition and start of contrast injection.

Fig 1. Delay time (Tdelay) was optimized between start of 4D-CT acquisition and start of contrast injection.
  • Choi W, Xue M, Lane BF, Kang MK, Patel K, Regine WF, Klahr P, Wang J, Chen S, D’Souza W, Lu W

  • Medical Physics. 2016 Oct 1;43(10):5659-66.

2016-10-18

Fig 1. Metastatic landscape of the KPCY model.

Fig 1. Metastatic landscape of the KPCY model.
  • Aiello NM, Bajor DL, Norgard RJ, Sahmoud A, Bhagwat N, Pham MN, Cornish TC, Iacobuzio-Donahue CA, Vonderheide RH, Stanger BZ

  • Nat Commun. 2016 Sep 15;7:12819.
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2016-10-19

Fig 1. Elevated [K+] within TIF silences the TCR-induced anti-tumour function of mouse and human T cells.

Fig 1. Elevated [K+] within TIF silences the TCR-induced anti-tumour function of mouse and human T cells.
  • Eil R, Vodnala SK, Clever D, Klebanoff CA, Sukumar M, Pan JH, Palmer DC, Gros A, Yamamoto TN, Patel SJ, Guittard GC

  • Nature. 2016 Sep 14;537(7621):539-543.

2016-10-20

Fig 2. Diagram of the phosphatidylinositol 3-kinase signaling pathway.

Fig 2. Diagram of the phosphatidylinositol 3-kinase signaling pathway.
  • Murphy CG, Dickler MN

  • Endocr Relat Cancer. 2016 Aug;23(8):R337-52.

2016-10-21

Fig 1. PI3K/AKT/mTOR signaling is regulated by intrinsic feedback.

Fig 1. PI3K/AKT/mTOR signaling is regulated by intrinsic feedback.
  • Wehrenberg-Klee E, Turker NS, Heidari P, Larimer BM, Juric D, Baselga J, Scaltriti M, Mahmood U

  • J Nucl Med. 2016 Sep;57(9):1413-9.

2016-10-24

Fig 6. Effect of PI3K inhibition on BCNP1 phosphorylation at serine residues.

Fig 6. Effect of PI3K inhibition on BCNP1 phosphorylation at serine residues.
  • Patel SJ, Trivedi GL, Darie CC, Clarkson BD

  • J Cell Mol Med. 2016 Sep 29.
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2016-10-25

Fig 3. Predicted differences in quality-adjusted survival benefit by age, ER status, and family history of breast cancer.

Fig 3. Predicted differences in quality-adjusted survival benefit by age, ER status, and family history of breast cancer.
  • Davies KR, Brewster AM, Bedrosian I, Parker PA, Crosby MA, Peterson SK, Shen Y, Volk RJ, Cantor SB

  • Breast Cancer Res. 2016 Sep 20;18(1):93.
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2016-10-26

Fig 6. Short timescale modes of inhibition translate to long timescale proliferative response.

Fig 6. Short timescale modes of inhibition translate to long timescale proliferative response.
  • Vogel RM, Erez A, Altan-Bonnet G

  • Nat Commun. 2016 Sep 30;7:12428.
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2016-10-27

Fig 1. Representative images of the longest diameters measured using calipers of a right cervical mass in (A) transverse plane, 2.6 cm and (B) coronal plane, 12.1 cm.

Fig 1. Representative images of the longest diameters measured using calipers of a right cervical mass in (A) transverse plane, 2.6 cm and (B) coronal plane, 12.1 cm.
  • Kumar A, Burger IA, Zhang Z, Drill EN, Migliacci JC, Ng A, LaCasce A, Wall D, Witzig TE, Ristow K, Yahalom J

  • Haematologica. 2016 Oct;101(10):1237-1243.
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2016-10-28

Fig 1. Three folding states of pHLIP peptides in decreasing extracellular pH: unfolded and unbound peptide in solution (State I), unfolded peptide loosely interacting with the membrane lipid bilayer at physiological pH (State II), and folded peptide in α-helical conformation inserted across the membrane at low extracellular pH (State III).

Fig 1. Three folding states of pHLIP peptides in decreasing extracellular pH: unfolded and unbound peptide in solution (State I), unfolded peptide loosely interacting with the membrane lipid bilayer at physiological pH (State II), and folded peptide in α-helical conformation inserted across the membrane at low extracellular pH (State III).
  • Demoin DW, Wyatt LC1, Edwards KJ, Abdel-Atti D, Sarparanta M, Pourat J, Longo VA, Carlin SD, Engelman DM, Andreev OA, Reshetnyak YK, Viola-Villegas N, Lewis JS

  • Bioconjug Chem. 2016 Sep 21;27(9):2014-23.
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2016-10-31

Fig 2. Percent change in target lesion size from baseline for 47 evaluable patient.

Fig 2. Percent change in target lesion size from baseline for 47 evaluable patient.
  • Gounder MM, Zer A, Tap WD, Salah S, Dickson MA, Gupta AA, Keohan ML, Loong HH, D’Angelo SP, Baker S, Condy M

  • J Clin Oncol. 2016 Sep 10;34(26):3166-74.

2016-11-01

Fig 1. A 52-year-old male with multiple HCCs.

Fig 1. A 52-year-old male with multiple HCCs.
  • Hu J, Maybody M, Cao G, Wang X, Chen H, Zhu X, Yang R, Wang X

  • Cancer Imaging. 2016 Oct 3;16(1):32.
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2016-11-02

Fig 1.Fine-needle aspiration of lung.

Fig 1.Fine-needle aspiration of lung.
  • Zakowski MF, Rekhtman N, Auger M, Booth CN, Crothers B, Ghofrani M, Khalbuss W, Laucirica R, Moriarty AT, Tabatabai ZL, Barkan GA

  • Arch Pathol Lab Med. 2016 Oct;140(10):1116-20.

2016-11-03

Fig 5. Optimization-based reconstructions fconv from the swine data with aortogram injection within a coronal slice specified by x  =  0.23 mm obtained with, respectively, parameter c  =  0.000, 0.025, 0.050, 0.075, 0.100, 0.200, 0.300 and 1.000, along with the reference reconstruction.

Fig 5. Optimization-based reconstructions fconv from the swine data with aortogram injection within a coronal slice specified by x  =  0.23 mm obtained with, respectively, parameter c  =  0.000, 0.025, 0.050, 0.075, 0.100, 0.200, 0.300 and 1.000, along with the reference reconstruction.
  • Xia D, Langan DA, Solomon SB, Zhang Z, Chen B, Lai H, Sidky EY, Pan X

  • Phys Med Biol. 2016 Oct 21;61(20):7300-7333.

2016-11-04

Fig 1. Individual Prediction Tools Included as Features in the REVEL Random Forest.

Fig 1. Individual Prediction Tools Included as Features in the REVEL Random Forest.
  • Ioannidis NM, Rothstein JH, Pejaver V, Middha S, McDonnell SK, Baheti S, Musolf A, Li Q, Holzinger E, Karyadi D, Cannon-Albright LA

  • Am J Hum Genet. 2016 Oct 6;99(4):877-885.

2016-11-07

Fig 9. Model that summarizes the proposed regulatory circuit that controls GBM phenotypes.

Fig 9. Model that summarizes the proposed regulatory circuit that controls GBM phenotypes.
  • Huang T, Alvarez AA, Pangeni RP, Horbinski CM, Lu S, Kim SH, James CD, Raizer JJ, Kessler JA, Brenann CW, Sulman EP

  • Nat Commun. 2016 Oct 4;7:12885.
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2016-11-08

Fig 1. The PRINT Process.

Fig 1. The PRINT Process.
  • DeSimone JM

  • J Control Release. 2016 Oct 28;240:541-543.

2016-11-09

Fig 1. Customized Sensing and Transcriptional Responses Using the synNotch Receptor in T Cells.

Fig 1. Customized Sensing and Transcriptional Responses Using the synNotch Receptor in T Cells.
  • Klebanoff CA, Restifo NP

  • Cell. 2016 Oct 6;167(2):304-306.

2016-11-10

Fig 5. Extramammary Paget disease.

Fig 5. Extramammary Paget disease.
  • Gill M, González S

  • Dermatol Clin. 2016 Oct;34(4):443-458.

2016-11-11

Fig 5. Preferential expression of Lgr5 in ventral ducts of the mammary gland during post-natal development, adulthood, and pregnancy.

Fig 5. Preferential expression of Lgr5 in ventral ducts of the mammary gland during post-natal development, adulthood, and pregnancy.
  • Zhang L, Adileh M, Martin ML, Klingler S, White J, Ma X, Howe LR, Brown AM, Kolesnick R

  • Cell Signal. 2016 Aug 7;29:41-51.

2016-11-14

Fig 2. N-Myc Overexpression Is Associated with Aggressive, NEPC-Like Prostate Cancer.

Fig 2. N-Myc Overexpression Is Associated with Aggressive, NEPC-Like Prostate Cancer.
  • Dardenne E, Beltran H, Benelli M, Gayvert K, Berger A, Puca L, Cyrta J, Sboner A, Noorzad Z, MacDonald T, Cheung C

  • Cancer Cell. 2016 Oct 10;30(4):563-577.

2016-11-15

Fig 1. Identical Differentiation Potential of PD iPSC and Control Lines.

Fig 1. Identical Differentiation Potential of PD iPSC and Control Lines.
  • Chung SY, Kishinevsky S, Mazzulli JR, Graziotto J, Mrejeru A, Mosharov EV, Puspita L, Valiulahi P, Sulzer D, Milner TA, Taldone T

  • Stem Cell Reports. 2016 Oct 11;7(4):664-677.
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2016-11-16

Fig 1. Schematic depicting structure of chimeric antigen receptors in largest published series to date.

Fig 1. Schematic depicting structure of chimeric antigen receptors in largest published series to date.
  • Geyer MB, Brentjens RJ

  • Cytotherapy. 2016 Nov;18(11):1393-1409.

2016-11-17

Fig 1. 4D-CT: Axial and reformatted CT images of the neck over time to diagnose abnormal parathyroid tissue.

Fig 1. 4D-CT: Axial and reformatted CT images of the neck over time to diagnose abnormal parathyroid tissue.
  • Taslakian B, Trerotola SO, Sacks B, Oklu R, Deipolyi A

  • Cardiovascular and Interventional Radiology. 2016 Oct 28:1-3.

2016-11-18

Fig 1. The interplay between the complement and the kinin generating systems on the endothelial cell (EC) surface.

Fig 1. The interplay between the complement and the kinin generating systems on the endothelial cell (EC) surface.
  • Ghebrehiwet B, Kaplan AP, Joseph K, Peerschke EI

  • Immunol Rev. 2016 Nov;274(1):281-289.

2016-11-21

Fig 1. Lymph Node Organization and the Vascular–Stromal Compartment.

Fig 1. Lymph Node Organization and the Vascular–Stromal Compartment.
  • Dasoveanu DC, Shipman WD, Chia JJ, Chyou S, Lu TT

  • Trends Immunol. 2016 Sep 13. pii: S1471-4906(16)30104-1.

2016-11-22

Fig 4. Electrostatic interaction of α-amino group with conserved active site aspartate.

Fig 4. Electrostatic interaction of α-amino group with conserved active site aspartate.
  • Davis TD, Mohandas P, Chiriac MI, Bythrow GV, Quadri LE, Tan DS

  • Bioorg Med Chem Lett. 2016 Nov 1;26(21):5340-5345.

2016-11-23

Fig 1. Assay design.

Fig 1. Assay design.
  • Borsu L, Intrieri J, Thampi L, Yu H, Riely G, Nafa K, Chandramohan R, Ladanyi M, Arcila ME

  • J Mol Diagn. 2016 Nov;18(6):903-911.

2016-11-25

Fig 1. Computed tomography (CT) images (a, b) before and (c) 15 d after one dose of nivolumab show an increase in pleural thickening.

Fig 1. Computed tomography (CT) images (a, b) before and (c) 15 d after one dose of nivolumab show an increase in pleural thickening.
  • Carlo MI, Feldman DR

  • European Urology. 2016 Dec 1;70(6):1082-3.

2016-11-28

Fig 4. The cysts of serous cystadenomas are lined by cuboidal cells, with round, central to slightly eccentric nuclei and clear cytoplasm (H&E, ×200).

Fig 4. The cysts of serous cystadenomas are lined by cuboidal cells, with round, central to slightly eccentric nuclei and clear cytoplasm (H&E, ×200).
  • Basturk O, Askan G

  • Surgical Pathology Clinics. 2016 Dec 31;9(4):619-41.

2016-11-29

Fig 4. miR-22 blocks rhabdomyosarcoma (RMS) tumor growth and dissemination.

Fig 4. miR-22 blocks rhabdomyosarcoma (RMS) tumor growth and dissemination.
  • Bersani F, Lingua MF, Morena D, Foglizzo V, Miretti S, Lanzetti L, Carrà G, Morotti A, Ala U, Provero P, Chiarle R

  • Cancer Res. 2016 Oct 15;76(20):6095-6106.

2016-11-30

Fig 5. NTP donor specificity of the AfuTrl1 and CimTrl1 5′ kinase reaction.

Fig 5. NTP donor specificity of the AfuTrl1 and CimTrl1 5′ kinase reaction.
  • Remus BS, Schwer B, Shuman S

  • RNA. 2016 Oct;22(10):1500-9.

2016-12-01

Fig 1 Longitudinal high-frequency ultrasound image of level 6 metastatic papillary thyroid cancer node measuring 1.2 cm with microcalcifications and rounded appearance.

Fig 1 Longitudinal high-frequency ultrasound image of level 6 metastatic papillary thyroid cancer node measuring 1.2 cm with microcalcifications and rounded appearance.
  • Scharpf J, Tuttle M, Wong R, Ridge D, Smith R, Hartl D, Levine R, Randolph G

  • Head Neck. 2016 Dec;38(12):1862-1869.

2016-12-02

Fig 1. Optical imaging of γ-emitters and photon beams.

Fig 1. Optical imaging of γ-emitters and photon beams.
  • Shaffer TM, Drain CM, Grimm J

  • J Nucl Med. 2016 Nov;57(11):1661-1666.

2016-12-05

Fig. 1. Day 7 relationships to prostate necrosis. a, energy delivery.

Fig. 1. Day 7 relationships to prostate necrosis. a, energy delivery.
  • Taneja SS, Bennett J, Coleman J, Grubb R, Andriole G, Reiter RE, Marks L, Azzouzi AR, Emberton M

  • J Urol. 2016 Oct;196(4):1096-104.

2016-12-06

Fig 1. First functional principal component (left column) and first functional partial least squares component (right column) for mucositis training (top row), dysphagia training (middle row), and dysphagia external validation (bottom row) data bootstrapped with 2000 replicates.

Fig 1. First functional principal component (left column) and first functional partial least squares component (right column) for mucositis training (top row), dysphagia training (middle row), and dysphagia external validation (bottom row) data bootstrapped with 2000 replicates.
  • Dean JA, Wong KH, Gay H, Welsh LC, Jones AB, Schick U, Oh JH, Apte A, Newbold KL, Bhide SA, Harrington KJ

  • Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):820-831.
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2016-12-07

Fig 8. Regions of BEST1 involved in Ca2+-dependent activation and ion selectivity.

Fig 8. Regions of BEST1 involved in Ca2+-dependent activation and ion selectivity.
  • Vaisey G, Miller AN, Long SB

  • Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7399-E7408.

2016-12-08

Fig 1. Photomicrographs showing immunohistochemical staining of programmed death-ligand 1 (PD-L1; 22C3 antibody) in melanoma (MEL) samples.

Fig 1. Photomicrographs showing immunohistochemical staining of programmed death-ligand 1 (PD-L1; 22C3 antibody) in melanoma (MEL) samples.
  • Daud AI, Wolchok JD, Robert C, Hwu WJ, Weber JS, Ribas A, Hodi FS, Joshua AM, Kefford R, Hersey P, Joseph R

  • J Clin Oncol. 2016 Dec;34(34):4102-4109.

2016-12-09

Fig 1. Relative position of infrarenal lumbar arteries (LA) and veins, right (R.) gonadal vein and inferior (Inf.) mesenteric artery.

Fig 1. Relative position of infrarenal lumbar arteries (LA) and veins, right (R.) gonadal vein and inferior (Inf.) mesenteric artery.
  • Beveridge TS, Allman BL, Johnson M, Power A, Sheinfeld J, Power NE

  • J Urol. 2016 Dec;196(6):1764-1771.

2016-12-12

Fig 1. Rates of management for clinical stage I seminoma of the testis for the years 1998-2012 from hospitals with consistent reporting throughout all study years.

Fig 1. Rates of management for clinical stage I seminoma of the testis for the years 1998-2012 from hospitals with consistent reporting throughout all study years.
  • Matulewicz RS, Oberlin DT, Sheinfeld J, Meeks JJ

  • Urology. 2016 Dec;98:113-119.

2016-12-13

Fig 1. Head and Neck Cancer Regions.

Fig 1. Head and Neck Cancer Regions.
  • Milazzo-Kiedaisch CA, Itano J, Dutta PR

  • Clin J Oncol Nurs. 2016 Dec 1;20(6):623-628.

2016-12-14

Fig 1. Computed tomography image of a patient with a horseshoe kidney.

Fig 1. Computed tomography image of a patient with a horseshoe kidney.
  • Mano R, Hakimi AA, Sankin AI, Sternberg IA, Chevinsky MS, Russo P

  • Urology. 2016 Dec;98:97-102.

2016-12-15

Fig 7. Apically Surfaced Cilia Can Ectopically Recruit Smoothened and Gli2 in the Absence of Agonist.

Fig 7. Apically Surfaced Cilia Can Ectopically Recruit Smoothened and Gli2 in the Absence of Agonist.
  • Mazo G, Soplop N, Wang WJ, Uryu K, Tsou MF

  • Dev Cell. 2016 Nov 21;39(4):424-437.

2016-12-16

Fig 1. Lineage Tracing Systems Demonstrate Heterogeneity in TAM Ontogeny in Multiple Models of Glioma.

Fig 1. Lineage Tracing Systems Demonstrate Heterogeneity in TAM Ontogeny in Multiple Models of Glioma.
  • Bowman RL, Klemm F, Akkari L, Pyonteck SM, Sevenich L, Quail DF, Dhara S, Simpson K, Gardner EE, Iacobuzio-Donahue CA, Brennan CW.

  • Cell Rep. 2016 Nov 22;17(9):2445-2459.
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2016-12-19

Fig 1. Mechanisms establishing CpG island methylator phenotype (CIMP) in colorectal cancer.

Fig 1. Mechanisms establishing CpG island methylator phenotype (CIMP) in colorectal cancer.
  • Miller BF, Sánchez-Vega F, Elnitski L

  • Biomolecules. 2016 Nov 22;6(4).
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2016-12-20

Fig 3. The Bcl2 family of proteins.

Fig 3. The Bcl2 family of proteins.
  • Younes A

  • Hematol Oncol Clin North Am. 2016 Dec;30(6):1229-1237.

2016-12-21

Fig 1. Graphical representation of BRCA1/2 heterozygous population frequencies in Exome Variant Server (EVS) and Exome Aggregation Consortium (ExAC) databases.

Fig 1. Graphical representation of BRCA1/2 heterozygous population frequencies in Exome Variant Server (EVS) and Exome Aggregation Consortium (ExAC) databases.
  • Maxwell KN, Domchek SM, Nathanson KL, Robson ME

  • J Clin Oncol. 2016 Dec;34(34):4183-4185.

2016-12-22

Fig 3. Risk-adjusted survival of consensus clinical stage groups.

Fig 3. Risk-adjusted survival of consensus clinical stage groups.
  • Rice TW, Ishwaran H, Blackstone EH, Hofstetter WL, Kelsen DP, Apperson‐Hansen C

  • Dis Esophagus. 2016 Nov;29(8):913-919.

2016-12-23

Fig.1 Proposed mechanism for MPL scavenging of TPO leading to neutropenia and thrombocytopenia in AML. PLTs, platelets.

Fig.1 Proposed mechanism for MPL scavenging of TPO leading to neutropenia and thrombocytopenia in AML. PLTs, platelets.
  • Goldberg AD, Tallman MS

  • Blood. 2016 Nov 3;128(18):2195-2197.

2016-12-27

Fig 1. Maps of BOLD functional MR imaging motor activation in a 59-year-old man with a GBM adjacent to the left PMC.

Fig 1. Maps of BOLD functional MR imaging motor activation in a 59-year-old man with a GBM adjacent to the left PMC.
  • Fraga de Abreu VH, Peck KK, Petrovich-Brennan NM, Woo KM, Holodny AI

  • Radiology. 2016 Dec;281(3):876-883.

2016-12-28

Fig 1. Dbr1 is a metallophosphoesterase.

Fig 1. Dbr1 is a metallophosphoesterase.
  • Schwer B, Khalid F, Shuman S

  • RNA. 2016 Dec;22(12):1819-1827.

2016-12-29

Fig. 3. Change in psychological well-being over acute treatment.

Fig. 3. Change in psychological well-being over acute treatment.
  • Keefe JR, Mao JJ, Soeller I, Li QS, Amsterdam JD

  • Phytomedicine. 2016 Dec;23(14):1699-05.

2016-12-30

Fig. 1. 
The conserved ClpB/DnaK bichaperone network resolves protein aggregates in mycobacteria. (A) Schematic of Mtb dnaK operon containing grpE, dnaJ1 and the regulator hspR. Another gene annotated as dnaJ2 is also present in the Mtb genome with the proposed regulator hrcA. ClpB is encoded by the gene Rv0384c. (B) Schematic of aggregated protein unfolding by the hexamer ClpB and refolding by DnaK with the assistance of the protein cofactors J proteins (DnaJs) and GrpE. DnaK and ClpB are ATPases. J proteins bring aggregated substrates to ClpB/DnaK and enhance ATP hydrolysis by DnaK. GrpE is a nucleotide exchange factor that stimulates release of ADP by DnaK. Small heat shock proteins (sHsps) are proposed to help solubilize aggregates for reactivation.

Fig. 1. The conserved ClpB/DnaK bichaperone network resolves protein aggregates in mycobacteria. (A) Schematic of Mtb dnaK operon containing grpE, dnaJ1 and the regulator hspR. Another gene annotated as dnaJ2 is also present in the Mtb genome with the proposed regulator hrcA. ClpB is encoded by the gene Rv0384c. (B) Schematic of aggregated protein unfolding by the hexamer ClpB and refolding by DnaK with the assistance of the protein cofactors J proteins (DnaJs) and GrpE. DnaK and ClpB are ATPases. J proteins bring aggregated substrates to ClpB/DnaK and enhance ATP hydrolysis by DnaK. GrpE is a nucleotide exchange factor that stimulates release of ADP by DnaK. Small heat shock proteins (sHsps) are proposed to help solubilize aggregates for reactivation.
  • Lupoli TJ, Fay A, Adura C, Glickman MS, Nathan CF

  • Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7947-E7956.