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Fig 1. TRIF-mediated DC maturation by LPS and poly(I:C) use IFN-independent and -dependent pathways, respectively. BMDCs of indicated genotypes were stimulated with LPS (A and B, 100 ng/mL), poly(I:C) (B, 20 µg/mL), or CpG (C, 1 µM) for 12 h and stained for surface expression of CD11c, CD86, CD40, and MHC-II. Histograms show CD11c+ cells expressing different maturation markers. Data are representative of two to five independent experiments.
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Fig 1. Immunohistochemistry of the TAZ protein in different subtypes of endometrial cancer (× 20)
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Fig 1. Generation of Spo11-oligo maps.
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Fig 2. Cytoscape visualization of the combined network.
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Fig 4. Co-expression of the Gata6 H2B-Venus reporter with endogenous GATA6 during early post-implantation development.
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Fig 2. Primary study end-point analyses.
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Fig 4. Hierarchical clustering of BCCLs based on (a) proteomic and (b) transcriptomic quantitative data.
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Fig 4. A 60-year-old man underwent surgical resection followed by stereotactic radiosurgery for an isolated left frontal metastasis secondary to lung adenocarcinoma.
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Fig 1. PFS for (A) all active treatment (watchful waiting excluded), (B) rituximab plus chemotherapy, and (C) rituximab monotherapy, and OS for (D) all active treatment (watchful waiting excluded), (E) rituximab plus chemotherapy, and (F) rituximab monotherapy, by age group and active first-line treatment.
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Fig 1. Structure of [18F]PARPi-FL and schematic for the automated synthesis: a structures of the fluorescent monomodal and 18F-labeled bimodal PARP1 targeted probes and b the synthesis of [18F]PARPi-FL is automated and performed in an 18F synthesis module. The upper panel shows the azeotropic distillation. The middle panel illustrates the fluorination/reaction step, followed by HPLC purification (lower panel).
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Fig 1. Immunosuppressive regulators in tumor microenvironment.
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Fig 2. NVOC-EMP1 is a photoactivatable ligand for TLR4 signaling.
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Fig 1. Exploring Complex Dependencies in Cancer Biology with Mathematical Modeling.
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Fig 1. Microscopic pictures of a 4-cm EHCC with EVI (7 foci) in a 44-year-old man without distant disease at presentation.
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Fig 1. Strategies for Targeting Epigenetic Regulators.
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Fig 1. Urinary 3-indoxyl sulfate generation.
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Fig 2. Representative images of PKM2 expression intensity.
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Fig 2. Nodes within the proteostasis network control the response of myeloma cells to carfilzomib.
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Fig 1. CSF ctDNA better captures the genomic alterations in patients with brain tumours than plasma ctDNA.
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Graphical abstract
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Fig 1. Kaplan-Meier survival curve for patients with >25 % hepatic tumor burden undergoing either hepatic resection or intra-arterial therapy (IAT) of gastroenteropancreatic neuroendocrine tumor liver metastases. Patients with high-volume, symptomatic disease benefit most from surgical intervention while those with high-volume asymptomatic disease benefit equally from surgical intervention versus intra-arterial theraphy months.
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Fig 1. Scheme of ligase evolution. RNA ligases, DNA ligases, and mRNA capping enzymes comprise a superfamily of covalent nucleotidyltransferases that act via enzyme-(lysyl-Nζ)–NMP intermediates. They are thought to descend from an ancestral ATP-using NTase domain (turquois oval) by fusions to structurally diverse flanking domain modules (depicted in various shapes and colors), as discussed in the text.
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Fig 3. Analysis of clonal architecture of IDH1/2-mutated cases.
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Fig 1. Granulocyte colony-stimulating factor (G-CSF). Structure and therapeutic forms of 1, 2, and designed 3.
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Fig 2. Hematoxylin and Eosin, 100× original image, prominent hyperkeratotic basket weave stratum corneum overlies an epidermis overtaken by necrotic keratinocytes at all levels, associated with vacuolar interface alteration and exocytosis of small lymphocytes.
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Fig 2. Proposed role of GS in DTs.
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Fig 5. Heat map displaying 50 stably expressed genes whose expression levels best differentiate (based on P value) melanoma patients (n = 7) from healthy donors (n = 10).
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Fig 6. Id1 deletion results in morphological and vascular functional changes in the colon.
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Fig 2. Evaluating metastasis of the ZMEL1 line using transplantation into the transparent casper recipient line.
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Fig 3. The costs per QALY gained ($1000) of colonoscopy screening for white females by screening history, comorbidity status, background risk for CRC, and age (3% discounted).
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Fig 3. Representative examples: regression of hypoxia (above, patient#15) vs. increase (week 2) followed by incomplete reduction (week 6) of hypoxia with residual hypoxia remaining (below, patient#16).
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Fig 3. MRI and magnetic resonance spectroscopic imaging of primary prostate cancer.
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Fig 3. Lhx1 function is essential for midline morphogenesis.
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Fig 2. Structural Basis of H3 Recognition by AF10PZP.
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Fig 3. PCA plots of drugs approved between 1981 and 2010 parsed by compound class.
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Fig 2. Activation of CD8+ T Cells and NK Cells during MCMV Infection.
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Fig 4. Interactions between T lymphocytes and HRS cells through the PD1 pathway.
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Fig 1. IDO-Positive Tumors from Melanoma Patients Show Increased Frequencies of MDSCs.
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Fig 1. Oncologists per 100,000 residents by hospital service area.
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Fig 1. Axial FLAIR images from case 1 (top row, left to right) demonstrate abnormal hyperintense signal in the bilateral thalami, mammillary bodies/hypothalamus, and posterior pons.
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Fig 4. A, B: Fine-needle aspiration of metastatic pleomorphic sarcoma.
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Fig 7. Interactions of Vis with M6 and NAD+.
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Fig 2. A working model summarizing the pathophysiology of bone marrow fibrosis in primary myelofibrosis.
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Fig 1. The pos-1 Gutless Phenotype Is Suppressed by neg-1 Loss of Function.
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Fig 2. A 64-year-old female patient with recurrent ovarian cancer.
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Fig 1. Examples of susceptibility artifacts for common percutaneous devices when placed perpendicular to 1.5-T main magnetic field.
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Fig 1. T cell activation and recruitment to tumor cells.
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Fig 1. (A) Organoaxial volvulus occurs when the stomach rotates along its long axis, placing the greater curvature anteriorly and the lesser curvature posteriorly. (B) Mesenteroaxial volvulus occurs when the stomach rotates along its short axis placing the antrum anteriorly and superiorly.
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Fig 4. DNAppG primer extension by mammalian polymerase β.
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Fig 1. PTPRD mutations are common in HNSCC and other cancers.
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Fig 2. AID Contributes to Epigenetic Diversity within GCB.
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Fig 1. The role of FANCM and partner proteins in coping with template lesions during DNA replication.
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Fig 1. Near-infrared fluorescence hyperspectral microscope.
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Figure 3. Docked complexes of 7 and MOR (A); 7 and DOR (B).
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Fig 2. Example of changes in spleen volume after 6 months of chemotherapy.
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Fig 2. Apoptotic membrane blebbing through the DR5/Casp-3/ROCK1 signaling pathway.
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Fig 1. An H&E stained section of mucosal rolls procured using our “rolling technique” showing a well preserved mucosa layer delineated by the muscularis mucosae at its base.
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Fig 1. Nomogram.
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Fig 2. Mutations detected by targeted sequencing and shared by at least 30% of DMs. The columns denote the samples (according to Table 1), the rows refer to the genes, and the green squares indicate mutations.
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Fig 1. Experimental approach.
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Fig 2. GCN2 phosphorylates eIF2α during mitochondrial dysfunction.
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Fig 1. PARP1 immunofluorescence staining of brain, U251 MG xenografts, and U87 MG xenografts.
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Fig 1. Recurrent CDKN1B mutations in classical HCL.
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![Fig 1. Structure of [18F]PARPi-FL and schematic for the automated synthesis: a structures of the fluorescent monomodal and 18F-labeled bimodal PARP1 targeted probes and b the synthesis of [18F]PARPi-FL is automated and performed in an 18F synthesis module. The upper panel shows the azeotropic distillation. The middle panel illustrates the fluorination/reaction step, followed by HPLC purification (lower panel).](https://library.mskcc.org/sparks/sparksimgs/3013/MolImagBiol_Carlucci.jpg)
