Fig 1. Recurrent CDKN1B mutations in classical HCL.

Fig 4. Absorbed dose modeling. Dose distribution profiles, generated by Metropolis for a 15-Gy arc therapy, with crosshairs showing the treatment center in coronal (A), transverse (B), and sagittal planes (C). The tumor is outlined in purple. (D) Dose-volume histogram for the tumor in the arc treatment plan.

Fig 4. Two motifs in Esco1 mediate its association with cohesin and gene-silencing activity.

P417 resides in the SBD. After sequence alignment, the location of Pro417 (P417) was mapped onto the structure of the E. coli protein DnaK using Protein Data bank file 2KHO.

Fig 1. Effects of decreased mitochondrial-protein import.

Fig 1. Distribution of mutations detected in DASISION at 3 years by treatment arm and BCR-ABL1 location.

Fig 7.1. The NK cell response against MCMV. A subset of natural killer cells in the C57BL/6 mouse express the activating receptor Ly49H, which recognizes the MCMV-encoded glycoprotein m157.

Fig 2. Proportion and number of DCIS cases undergoing breast-conserving surgery versus therapeutic mastectomy, by year.

Fig 1. Medical oncologists’ estimated distributions of patient attitudes for research purpose-only biopsies (RPOBs) of the breast (A) and RPOBs of the liver (B).

Fig 1. Scatter plot of all sirolimus concentrations, with a lowess local regression curve (red). The suggested therapeutic range of 3–12 ng/mL and the median concentration is outlined for reference.

Fig 2. Maximum Percent Change from Baseline in the Sum of the Diameters of Target Lesions.

Figure 1. Immunofluorescence staining to determine BRCA1 subcellular expression.

Fig 7. A Model for Recruitment of Aub and Ago3 to Nuage and Formation of the 4P Complex.

Fig 2. Schematic of the methodology for acquiring hyperpolarized 13C metabolite DW images and generating ADC maps. The example data shown are of a hyperpolarized 13C pyruvate phantom at 22°C.

Fig 1. MRI and autopsy findings.

Fig 4. H&E staining of infected lungs at 24 h following infection.

Fig 1. Two concepts of using oncolytic virus for cancer treatment.

Fig 7. Central Role of Intestinal Mfs in Generation of Commensal-Induced Th17 Cells.

Graphical abstract

Fig 1. A Transverse and B sagittal contrast-enhanced CT images obtained in a 51-year-old woman with clear cell carcinoma of the uterine corpus demonstrate bulky endometrial tumor with deep myometrial invasion (arrow), dilation of the endocervical canal by the tumor and irregular interphase between the tumor and cervical stroma (arrowhead). C Transverse and D coronal contrast-enhanced CT images performed in a 49-year-old woman with clear cell carcinoma of the uterine corpus demonstrates deeply invasive tumor including frank cervical stromal invasion (arrowhead).

Fig 1. Type 1 superior thyroid pole featuring a narrow pyramid-shape superior pole with narrow vascular pedicle.

Fig 1. Encapsulated follicular variant of papillary thyroid carcinoma. a Low-power view showing tumor (T) surrounded by its capsule (cap) with no invasion. b Medium-power view revealing follicular growth with densely eosinophilic colloid characteristic of papillary thyroid carcinoma follicular variant. c High-power view of the nuclear features of papillary thyroid carcinoma: hypochromatic, irregular, overlapping nuclei with grooves (the latter indicated by an arrow). d Mass spectrometry traces for NRAS codon 61 mutation from the tumor. Note the mutant NRAS 182G (indicated by M) and wild type (W) peaks (reprinted with permission from Rivera et al.

Fig 4. A Low magnification image of the transverse section of the nerve and muscle at the site of ablation. Areas of ablation of the nerve and muscle are delineated. Note vascular hyperemia in the ablated portion of the nerve (arrow), and hemorrhage in the adjacent muscle (asterisk). Scale bar 1 mm. B High magnification, transverse section of the nerve at the site of ablation, (the area within the small box on image A. Note nuclear pyknosis of Schwann cells (arrow), with normal axons and myelin sheaths, and perineurial edema (asterisk) with hyalinization of collagen (arrowhead). Scale bar 20 μm. C High magnification, transverse section of nerve at site of ablation. Note nuclear pyknosis of Schwann cells (arrow), with dilated myelin sheaths and loss of axons (arrowhead), and perineurial edema (asterisk). Scale bar 20 μm. D High magnification, transverse section of nerve proximal to site of ablation. All structures are normal.

Graphical Abstract

Fig 2. The clonality of tumor evolution.

Fig 1. The structural characterization of EcEndoV.

Figure 2. Performance of the EC-NMR method.

Horizontal line profiles through centers of reconstructed images [Figs. 3(e)–3(h)] and ground truth [Fig. 1(c)]. Peaks at pixels 17 and 68 represent centers of Gaussian spheres with FWHM values 21.1 and 14.1 mm, respectively.

Fig 2. Metaplastic breast cancers of basal-like and claudin-low intrinsic subtypes are distinct at the molecular level.

Fig 2. Basic Characteristics of Numerical Chromosomal Instability in Clonal Populations.

Fig.2 ERBB2 immunohistochemistry and chromogenic in situ hybridization correlation.

Fig 8. sem-2 affects the development of RME motor neurons.

Figure 1. Physiological Levels of Extracellular Proteins Provide Nutritional Benefits for Wild-Type and K-Ras Mutant Cells

Fig 2. Menstrual status at protocol-specified time points.

Figure 1: Characterization of primary cultured NFs and CAFs

Fig 1. Selected members of the oridamycin and xiamycin families.

Fig 1. Clinical activity in patients with non–small-cell lung cancer (NSCLC) receiving nivolumab. Kaplan-Meier curves of overall survival (OS) for (A) total patient population (N = 129) and (B) patients who received nivolumab 1 (n = 33), 3 (n = 37), or 10 mg/kg (n = 59).

Figure 1. Large numbers of preTs containing the transgene of a specific TCR under the regulation of an inducible promoter were generated in vitro.

Fig 7. IL-4 and IL-13 blockade does not increase corneal angiogenesis.

Fig. 7. Proposed model for the role of association between p53 and BRCA1 in the regulation of HR activity.

Figure 1: This work focuses on analyzing robustness with respect to pairwise interactions

Fig 1. Operating characteristics for hypothetical dose-toxicity curves and initial dose-toxicity curves in a trial design with 10 dose levels

FIGURE 1. In vitro uptake of radiolabeled probes in human T cells transduced with different reporters.

Figure 1. Examples of mouse prostate organoid and human prostate cancer organoid

FIG 1 Recombinant RnhC. (A) Primary structure

Figure 1. Canonical and revised view of RAG binding.

Fig 1. Chemical structures of compounds investigated in our study.

Fig 1A. 38-year-old female kidney donor. Segmentation of renal cortex. Only tissue not shaded green is used for 3D reconstruction. A, Axial CT image.

Fig 4. Induction of anchorage-independent growth by SW620 and CRC-MF conditioned media was dependent on CXCL1.

Figure 1. The cumulative incidence of CMV infection in the first year after CBT in CMV seropositive recipients according to the method of monitoring.

Fig 2. Best response, progression-free interval, and overall survival for individual patients.

Fig 3. Percentage of abnormal plasma cells/all plasma cells within the bone marrow compartment (aPCs/BMPCs) by flow cytometry represented per patient, location and order of aspirate pull.

Fig 1. Anti-CD19 CAR T cell (the third generation) recognizes CD19 antigen on a tumor cell via an anti-CD19 single chain Fv (scFv) binding domain.

Fig 1. Transplanted peripheral blood progenitor cell dose (CD34+) and probability of platelet recovery (platelets ≥ 20 × 109/L).

Fig 3. A) Symmetrical dermal melanocytic tumor with adipocytic metaplasia. B) Epithelioid melanocytes with enlarged nuclei. C) Tumor cells with abundant, ‘glassy’ cytoplasm. D) Melanocytes with nuclear pseudoinclusions, some with melanin pigment.

Fig 1. Example of WBRT field used to treat a patient with PCNSL. The globes of the eyes are outlined.

Fig 1. Association between mutations or CNV and OS.

Fig 1. Screen for miRNAs impacting on endogenous p53 levels. Results of the screen for miRNAs impacting on p53 protein levels.

Figure 1. Results of the final step of hierarchical linear regression analysis among (a) patients who quit smoking prior to diagnosis

Fig 1. Sema 3A stimulates NRP-1-mediated PTEN phosphorylation and nuclear translocation in breast cancer cells.

Fig 1. MW ablation performed with the probe in a perpendicular orientation and the ablation zone including the pleural puncture site.

Fig. 1 Survival in patients with sporadic and familial MPNs.

Figure 1. Development stress promoting heightened allostatic load may result in diminished cognitive resources underlying adaptive coping with cancer stress and increased risk for cancer-related neurocognitive sequelae

Fig. 2. Microphotographs of a 5-cm invasive EFVPTC in a 62-year-old woman who presented with lung metastasis and a serum thyroglobulin level of 13 900 ng/mL.

Fig 1. Effect of Sirs on Transcription of a1.