Fig 1. Overall structure of FAN1-5′pG1/3′T4. (A) Cartoon representation. NTD, pink; CTD, light blue, dsDNA, yellow; flaps and 5′ phosphate spheres, red; and Ca2+, purple. The inset shows a line drawing of the DNA. (B) View looking down the vertical axis of (A). (C) The six different domains of FAN1 are colored according to the linear representation. WH, winged helix.

Fig 3. Unadjusted Kaplan-Meier curve for overall survival.

Fig 1. Structure of BRAF and RAF1 fusions.

Fig 6. Structural perturbations in the acceptor site of the GTP-Mg2+-pDNA complex. The structures of the CthPnk-D38N-GTP-Mg2+-HODNA Michaelis complex (PDB code 4MDF; cyan) and the wild-type CthPnk-GTP-Mg2+-pDNA complex (green) were superimposed. The DNA ligands and selected side chains are shown as stick models in a stereo view highlighting changes in side chain position and orientation caused by the DNA 5′-phosphate. The blue line denotes the 4.8 Å displacement of the Glu48 Cα atom of the loop segment connecting two α helices that form the acceptor-binding site.

Fig 4. Impact of APOE and smoking status for working memory. The bar plot of the observed average post-treatment working memory outcomes is shown. The error bars represent the model-predicted 95% confidence intervals. Specific statistical contrasts were applied to test the APOE4 and smoking history interaction within patients treated with chemotherapy (contrast (a)), patients not treated with chemotherapy (contrast (b)), and controls (contrast (c).)

Graphical Abstract.

Fig 3. Effects of AAVrh10.BevMab on angiogenesis of ovarian cancer. A2780 cells (5 × 106) were administered intraperitoneally into Balb/c nude mice. One day after tumor cell inoculation, mice were treated with 1011 gc AAVrh10. BevMab or, as controls, AAVrh10.αPA or PBS. On day 24, tumor nodules were collected. Frozen sections were stained with rat anti-mouse CD31 followed by goat anti-rat IgG conjugated with cy3. Nuclei were stained with DAPI. A. CD31 + tumors for PBS control, AAVrh.10αPA control and AAVrh.10BevMab. B. Quantification of blood vessel area. Data were obtained from n = 4 mice per group.

Fig 1. SP MF CD34+ cells responded to the treatment of AZD1480 in a dose-dependent fashion, whereas normal CB CD34+ cells were less responsive to the effects of AZD1480.

Fig 1. NRAS and PIK3CA mutations in ECD histiocytes and CD14+ cells from peripheral blood.

Fig 1A. Smoking dysregulated genes in the small airway epithelium. Volcano plot, smoker vs nonsmoker small airway epithelium (n = 29 nonsmokers and n = 29 smokers) using all expressed (P call ≥10) probesets as input dataset.

Fig 1a. Identification of gene expression subtypes in EEC.

Fig 1a. Waterfall plot, response of 32 human PDAC tumor xenografts to gemcitabine.

Graphical Abstract

Fig 2. Cisplatin–DNA adduct formation and immunofluorescence: Visualization of cisplatin intrastrand DNA adducts in one patient's tumor tissue sample before and after HIPEC; the other two patients showed similar results.

Fig 1. gE/AS01B, glycoprotein E/liposome-based adjuvant (50 µg MPL, 50 µg QS21); gE/AS01E, glycoprotein E/liposome-based adjuvant (25 µg MPL, 25 µg QS21); SAEs, serious adverse events. *Four subjects (2 in the gE/AS01E and 2 in the saline groups) with confirmed HZ were included in the safety analysis but were excluded from the immunogenicity analyses at month 15.

Graphical abstract.

Graphical Abstract.

Fig 1. Sustained neutrophil engraftment after myeloablative double-unit CBT by infused viable CD34+ cell dose per kilogram of the dominant unit (n = 128).

Fig 4. Waterfall plot of best CNS response. Bars indicate the change from baseline in the size of CNS tumours, for every assessable patient with measurable CNS lesions at baseline (n=9). Red box indicates patients who had a partial response as their best CNS response. + symbols indicate patients still on treatment. *Radiation necrosis.

Fig 1. p19Arf deficiency significantly suppresses prostate tumorigenesis in Pten/Trp53 mice. (A) Actual sizes of representative tumors from anterior prostates (APs) of Wt, Ptenpc–/–; Trp53pc–/– double-mutant, and Ptenpc–/–; Trp53pc–/–; p19Arf–/– triple-mutant mice at 6 months of age.

Fig 3. Kaplan–Meier survival analysis in GEICAM/9906 and METABRIC data sets based on the PAM50 proliferation score. Patients with (A) TNBC and (B) TNBC and BLBC treated with adjuvant chemotherapy in GEICAM/9906.

Fig 1. An intestinal-type ampullary adenocarcinoma showing a cribriform architectural pattern (A) and nuclear hyperchromasia and pseudostratification (B) on H&E.

Fig 1. Independent-samples t-tests of group differences between men classified into “low” vs. “high” sexual bother groups.

Fig 3. Waterfall plot of best tumour response. Response was measured as the largest post-baseline percentage reduction in the sum of longest diameters of target lesions for all assessable patients with a radiographic post-baseline assessment (n=42).

Fig 1. Study treatment schema and comparison with the European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada (EORTC/NCIC) standard glioblastoma regimen (1). BEV, bevacizumab; RT, radiotherapy; TMZ, temozolomide.

Fig 2. (L) Immunofluorescence staining of spleen sections showing DsRed-MLL-AF9 cells, CD45-expressing (green) cells, and 4,6-diamidino-2-phenylindole nuclei staining (blue). Left panel (×10); right small panels (×63).

Fig 4. Virus protein ICP6 interacts with RIP3 through the RHIM domains of both proteins and is required for HSV-1–induced necrosis. (A) RIP3 KO MEFs expressing WT RIP3 (RIP3 was double tagged with Flag and HA) infected with HSV-1 (MOI = 2) for 5 h. Cell lysates were collected and immunoprecipitated with anti-Flag and anti-HA agarose beads as described in Materials and Methods. The eluted RIP3-associated complexes were subjected to SDS/PAGE and detected by silver staining. The indicated bands were excised and then digested and analyzed by mass spectrometry.

Fig 1B. Cartoon renderings (see Materials and Methods; unprocessed images are shown in supplementary material Fig. S2) of typical aggregate morphologies on day 5 following the conditions shown in A; images are not to scale. Maximum elongation was observed following pulsed treatment within the day 2-3 time frame (P3).

Fig 1. MyD88-dependent fucosylation of small intestine IECs by systemic stimulation of TLRs.

Fig 1. Nanoparticle quenching of Cerenkov luminescence.

Graphical abstract: To ensure that DNA replication during meiosis is followed by recombination events, a kinase that can promote the formation of double-strand breaks is recruited to the replisome. Consequently, the DNA breaks that initiate recombination are primed to form in the wake of the replication fork.

Graphical abstract: Here, we show that a dedicated Foxp3 intronic element CNS2 maintains Treg cell lineage identity by acting as a sensor of the essential Treg cell growth factor IL-2 and its downstream target STAT5. CNS2 sustains Foxp3 expression during division of mature Treg cells when IL-2 is limiting and counteracts proinflammatory cytokine signaling that leads to the loss of Foxp3. CNS2-mediated stable inheritance of Foxp3 expression is critical for adequate suppression of diverse types of chronic inflammation by Treg cells and prevents their differentiation into inflammatory effector cells. The described mechanism may represent a general principle of the inheritance of differentiated cell states.

Figure 3. Quality of Life Mean Scores of the EORTC QLQ-C30 by levels of Fatigue and Haemoglobin. The upper panel reports mean scores of the global health status/quality of life (QoL) scale of the EORTC QLQ-C30 by levels of fatigue, defined by quartiles of the FACIT Fatigue scale distribution. . The lower panel reports mean scores of the global health status/QoL scale of the EORTC QLQ-C30 by levels of haemoglobin (Hb) values (g/l), defined by quartiles of Hb distribution.

Fig 1. Molecular mechanism of androgen receptor (AR) signaling in castrate-resistant prostate cancer.

Fig 4. Socioeconomic Characteristics Of Communities Served By Hospital-Affiliated Clinics In Comparison To Characteristics Of Communities Served By Disproportionate-Share Hospitals, By Time Of Registration For The 340B Program

Fig 3. Tumor MRE11 status is significantly prognostic for DFS and OS. (A) Disease free survival for dMRE11 (n = 70; events = 24); 5-yr rate: 67% (95% CI: 56–79%) vs. pMRE11 (n = 555; events = 240); 5-yr rate: 59% (95% CI: 55–63%). (B) Overall survival for dMRE11 (n = = 70; events = 23); 5-yr rate: 68% (95% CI: 58–80%) vs. pMRE11 (n = 555; events = 194); 5-yr rate: 71% (95% CI: 67–75%).

Fig 4. Representative coronal PET images (Maximum Intensity Projection) of SCID mice bearing SK-BR-3 xenografts on the right shoulder. Images A, B and C are the results of 15-min static scans following iv injection of the mouse with [18F]-18. Images A, B and C were obtained at 30, 60 and 240 min after injection, respectively.

Fig 1. CONSORT diagram for GOG (Gynecologic Oncology Group) 0199, the National Ovarian Cancer Prevention and Early Detection Study. ROCA, risk of ovarian cancer algorithm; RRSO, risk-reducing salpingo-oophorectomy.

Fig 2. 3-arm and 4-arm constructs can be radiolabeled in 1 step at 37°C. (B) Time course of labeling at different temperatures.

Fig 1. Cumulative incidence of subsequent malignant neoplasms after retinoblastoma by treatment received. (A) Bone tumor.

Fig 2. Fracture-free survival by type of urinary diversion in patients who received cystectomy.

Graphical abstract.

Fig 2. Example of a case (case 1). A, Hematoxylin-eosin. B, Immunostain for podoplanin/D2-40. C, Immunostain for CD31. D, Immunostain for CD68 (original magnifications ×100).

Fig 3. General model of palliative care services integrated into oncology practice. MA, medical assistant; RN, registered nurse.

Fig 2. Cumulative incidence curve for local recurrence by radiation treatment group. C-EBRT, conventional external-beam radiation therapy; HR, hazard ratio; IMRT, intensity-modulated radiation therapy; M, multivariable; U, univariable.

Figure 1A and 1B. Fundus Photograph of Case 1. A, Vitreous seed tethered to the injection site following 2 intravitreal melphalan injections B, One year later, following cryotherapy and 3 additional injections, the vitreous seed has regressed to a collection of pigment.

Fig 1. Cumulative incidence of death by smoking status (left) and pack-years among smokers (right).

Fig 1. CD8+ and DC-Lamp+ cell densities are heterogeneous in non-small cell carcinoma.

Fig 4a. Whole genome analysis of mutational concordance. Concordant and discordant non-synonymous mutations and indels for four CRC patients.

Fig 4b. SCCRO5 overexpression is common in human tumors and correlates with outcomes. Western blot analysis showing SCCRO5 protein expression in representative head and neck and lung SCCs (T) and matched normal (N) samples.

Fig 5. Histiocytic sarcomas and soft tissue sarcomas from mice with Ptprd and Cdkn2a deletion.

Fig 3. Kaplan–Meier curve showing PFS in patients who received the concurrent regimen of afatinib and cetuximab.

Fig 1. Human prostate cancer tumor harvesting and flow cytometry plot illustrating specific populations from a human prostate cancer. (A) Tumor nodules are harvested to generate a cell suspension. Tumor content of the processed sample is confirmed using conventional Hematoxylin and Eosin staining. (B) Cells staining positively for DAPI are excluded to isolate only viable cells.

Fig 1. Estrogen receptor (ER)–positive and ER-negative breast cancers are fundamentally different diseases.

Fig 1. Diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH). This tumorlet from a patient with DIPNECH consists of nodular clusters of neuroendocrine cells in a peribronchiolar location, causing compression of the bronchiolar lumen (Hematoxylin and eosin ×20).

Fig 1. A LigD-LIG-independent NHEJ pathway participates in chromosomal repair. (B) Fraction survival of wild-type (wt), ligD-(K484A), and ΔligD strains was plotted in log scale with the IR dose on the x axis.

Fig 2B. There was no difference in disease-free survival in patients who were MRD-negative after the completion of consolidation therapy, regardless of whether they received an additional 1 year of maintenance therapy with ATRA, methotrexate (MTX), and 6-mercaptopurine (6-MP) or were observed.

Fig 1. Kaplan–Meier probability curves for RFS after reflex FISH stratified by FISH result. Differences in RFS are statistically significant (P < 0.001, log-rank test).

Fig 2. DGK-α is required for MTOC polarization in TCR photoactivation experiments.

Fig B. The treatment history and genomic landscape of a metastatic carcinoma with an extreme outlier response to combination therapy. CT images of the index patient before surgery of the recurrent tumor, before combined AZD7762 and irinotecan therapy, and 1 month after combined treatment (left, middle, and right, respectively).

Fig 1. Representative case (patient 4) of salt-and-pepper retinopathy after intravitreal melphalan.

Fig 1. (A) Disease-free survival (DFS) of all patients undergoing R0 resection (n = 115).

Fig 3. Kaplan-Meier 10-year breast cancer-specific survival analyses in the molecular taxonomy of breast cancer international consortium dataset (all patients). B) Based on intrinsic subtype and cHER2 status.