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Fig 1. Two Paths for UV-Induced Squamous Cell Carcinoma in a well-established process.
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Fig 1a. Network analysis connecting those gene products genetically implicated in human cell transformation.
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Fig 1. Gap-junction-mediated electrical coupling between sister excitatory neurons in neonatal neocortical ontogenetic columns.
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Fig 1. SUVmax (A) and average SUV (B) in muscle groups and liver and spine background regions in 3 patient groups. CI = confidence interval.
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Secondary structure schematic of the 52-nucleotide sensing domain of the T. petrophila fluoride riboswitch used in this study.
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Fig 4G. PRK2 function is RhoA-dependent, kinase-dependent, and requires its C2-like domain. (G) Cells were fixed and stained with anti-ZO-1 (green) and Hoechst stain (blue).
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Fig 1. Recurrence-free survival comparing open partial nephrectomy versus minimally invasive partial nephrectomy.
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Fig 1. A single leading-strand template CPD provides only a transient block to replisome progression.
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Fig 1. Overall survival (A) and cancer specific survival (B) curves for patients with SqD and SCC treated with RCPLND. TCC, transitional cell carcinoma.
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Fig 1. Overall survival from start of MEC or ME by type of treatment.
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In the simulation, PSCBS compares favorably to established methods.
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Fig 1a. Survival endpoints stratified according to FIGO stage.
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Figure 1. Probability of freedom from disease recurrence and disease-specific survival after treatment of metastatic NSGCT for patients with CCR and PCR.
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Fig 1. Effective early infection by GLV-1h68 of human sarcoma cell lines.
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Fig 5. The Fc receptor signals are required for augmented antitumor effects by the combination treatment.
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Fig 10.1. Multiple processing events generate the mature Shh signaling protein.
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Fig 1. A 52-year-old woman with biopsy-proven malignant melanoma of the right upper arm developed metastases in the lung, subcutaneous tissues, and the right kidney.
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Fig 1c. A sagittal view of the original intensity-modulated radiotherapy (IMRT) plan illustrating the dose distribution in the primary site and the upper neck.
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Fig 1. Gli transcriptional activation is dispensable for pancreatic development.
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Figure 2. Waterfall plots of percent change from baseline in measurable tumour at the time of best response
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Scheme 2. Reagents and conditions. (a) TFA, DCM, rt; (b) benzophenone-4-carboxylic acid, EDCI, HOBt, DIPEA, DMF, 52% over 2 steps; (c) LiOH, H2O, DME; (d) TBSCl, Imidazole, DMF; (e) MeOH, 60% over 3 steps; (f) 10, EDCI, HOBt, DIPEA, DMF, 91%; (g) TBAF, THF, 60%.
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Fig 1. Cumulative incidence of seizure or death without seizure after diagnosis of brain metastasis among patients who did not present with seizure (n = 95).
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Fig 2. Semi-quantitative fragment analysis of RT-PCR products revealed the presence of the same alternative transcripts in the patient, her father, and control persons, but at different ratios. Quantification of the three transcripts using the peak height.
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Fig 5. HSV1-tk imaging of cancer dissemination along the sciatic nerve.
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Figure 2. Images in a 75-year-old man with progressive metastatic prostate cancer starting protocol therapy with abiraterone acetate, an enzyme inhibitor that reduces blood levels of testosterone.
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Fig 1A. Kaplan–Meier estimates of PFS by treatment group in the patients intolerant of previous VEGFr-TKI therapy.
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Fig 1. Survival similar in 3 age cohorts after HCT for CML.
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Fig 1C. Endometrioid carcinoma exhibiting focal, weak and heterogeneous staining.
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Fig 3. Reasons for implant removal versus replacement are depicted.
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Fig 4a. Cells with fragmented mitochondria are resistant to mPTP opening, which can be reversed by restoration of fused morphology.
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Fig 1(A). Identification of piRNAs in Aplysia Neurons.
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Fig 1. The two definitions of the chest wall (CW) as an organ at risk.
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Fig 1(C). Schematic of the many oncogenic activities attributed to miR-17∼92, with special emphasis on its role as a modulator of cell proliferation.
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Fig 1. Ago1 distribution in Drosophila egg chambers.
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Fig 1. Campaign to improve recognition of back melanoma. Printed with permission.
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Fig 1b. SAHA induces autophagy and LC3 up-regulation in MEF cells.
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Fig 1. The number of patients evaluated each year for a cystic lesion of the pancreas (blue bars) and the median size (red line) of the lesion at initial visit (1995 to 2010, N = 1,424).
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Fig 2. Mutational analysis of the mir-451 hypervariable stem position.
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Fig 4. Case 2. (B) Re-excision pathology with multiple benign syringomatous proliferations confined to the dermis (H&E, × 10 magnification).
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Fig 3. Cumulative incidences of recurrence by stage (treating death from other causes as a competing risk) in patients undergoing preoperative chemotherapy±radiation therapy for gastric and gastrooesophageal junction adenocarcinoma, followed by R0 resection.
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Fig 1. Location of lymph node packets and boundaries of dissection for extended pelvic lymphadenectomy, including the inferior mesenteric artery superiorly, the genitofemoral nerve laterally, and the node of Cloquet inferiorly.
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Fig 3. Cell passage – upon day 10 the tissue will appear dramatically thicker with densely packed nuclei and phase-bright ridges.
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Fig 1. Schematic of workflow. Modifications to a previously reported TK screening platform (Chmielecki et al.,2010) were incorporated to take advantage of short-read paired-end sequencing using an ABI SOLiD sequencer.
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Fig 1. Treatment Landscape for CML PatientsThe figure denotes current and novel therapeutic options for CML patients. Imatinib therapy reduces leukemia bulk cells, but does not deplete leukemia stem cells (LSCs). By contrast, inhibition of Wnt signaling inhibits LSCs but not bulk leukemia cells.
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Fig 1. Beta-catenin signalling is not detectable in early nephrogenic tissues, suggesting that Wnt4 acts through a non-canonical pathway during nephrogenesis.
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Fig 7. Gradients of lymphatic fluid stasis regulate the expression of adiponectin.
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Fig 3. Coronal whole-body projection images of a patient who had received an oral barium contrast agent before the PET scan.
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Fig 1. Mutations of epigenetic modifiers identified in patients with myeloproliferative neoplasms (MPNs).
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Fig 4. Akirin protein is broadly distributed throughout the genome.
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The overall estimate for the effects of false-positive mammogram results on screening reattendance remains null for Europe, based on our revised meta-analysis of data from over 340,000 women.
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Fig 1. Schematic description of Bioorthogonal Profiling of Protein Methylation (BPPM).
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Fig 1. By disabling the inhibitory functions of CTLA-4, ipilimumab enhances T-cell activity.
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Fig 1. Trafficking and processing of Ras.
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Fig 1. The different mechanisms that lead to polyploidy.
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Fig 1. Patient disposition. Values given as number of patients with TPCs in parentheses. Percentages are out of total TPCs. TPC, tunneled pleural catheters.
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Fig 5. MEMRI demonstrated an altered tonotopic map in Fgf17−/− IC.16- (green) and 40-kHz (red) activity patterns and centroids (small green and red circles) were measured in the IC of Fg17+/− (A) and Fg17−/− (B) mice.
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Fig 3. Increasing second primary malignancy (SPM) rates with time for all malignancies and leukemias are illustrated in patients with well differentiated thyroid cancer (WDTC).
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Fig 1. Bland–Altman plot. The mean difference between the two measurements is shown with a solid line at 5.49 mm; the lower and upper 95% limits of agreement are the dashed lines at −12.31 mm and 23.30 mm.
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Fig 1a. Interaction network of C/EBPα and PPARγ derived from Ingenuity pathway analysis.
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Fig 1. Carrión-Rosello Cavernotomes.
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Fig 2. Single-photon emission computed tomography image of cervical sentinel lymph nodes providing more precise anatomic localization in a patient with melanoma of the scalp.
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Fig 1. A, Dermatoscopic image of asymmetric pigmented lesion (group A) on lower aspect of the back of a 57-year-old man
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Fig 1a. Representative staining for NRP2 in normal human tissues. Normal Kidney.
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Figure 2. Neuroendocrine marker immunohistochemistry in large cell neuroendocrine carcinoma. (A) Strong reactivity for synaptophysin and for (B) chromogranin-A in a laryngeal tumor (both 400× magnification).
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