Return to Today's science sparks archives

Information Click the tweet icon above each article title to share it on Twitter.

2011-09-30

Using a cervical injection for mapping, metastatic cells from endometrial cancer are three times as likely to be detected in SLN than in the non-sentinel nodes.

Using a cervical injection for mapping, metastatic cells from endometrial cancer are three times as likely to be detected in SLN than in the non-sentinel nodes.
  • Khoury-Collado F, Murray MP, Hensley ML, Sonoda Y, Alektiar KM, Levine DA, Leitao MM, Chi DS, Barakat RR, Abu-Rustum NR

  • Gynecol Oncol. 2011 Aug;122(2):251-4.

2011-09-29

Fig 1. Images from a 48-year-old male with an incidental diagnosis of a left renal mass.

Fig 1. Images from a 48-year-old male with an incidental diagnosis of a left renal mass.
  • Adamy A, Von Bodman C, Ghoneim T, Favaretto RL, Bernstein M, Russo P

  • BJU Int. 2011 Aug;108(3):338-42.

2011-09-28

Fig 1A. Axial chest CT image viewed with lung windows, demonstrating a smooth lesion on the lateral wall of the trachea.

Fig 1A. Axial chest CT image viewed with lung windows, demonstrating a smooth lesion on the lateral wall of the trachea.
  • Chand M, Mann JM, Sabayev V, Luo JJ, Cohen PR, Travis WD, Lee PC, Paul S

  • Chest. 2011 Jul;140(1):242-4.

2011-09-27

Fig 1. Sinonasal adenocarcinoma, intestinal-type, from patient 1 (A) and patient 2 (B) with colonic and papillary architecture, respectively.

Fig 1. Sinonasal adenocarcinoma, intestinal-type, from patient 1 (A) and patient 2 (B) with colonic and papillary architecture, respectively.
  • Bhagia P, Colanta AB, Abramson DH, Carlson DL, Kleinerman RA, Kraus D, Dunkel IJ

  • Pediatr Blood Cancer. 2011 Oct;57(4):693-5.

2011-09-26

Fig 1. Evaluation by a dermatologist revealed grade 1 koilonychia.

Fig 1. Evaluation by a dermatologist revealed grade 1 koilonychia.
  • Daher M, Lacouture ME, Rathkopf D, Maki RG, Keohan ML, Gansukh B, Chen H, Abou-Alfa GK

  • J Clin Oncol. 2011 Jul 20;29(21):e638-40.

2011-09-23

Fig 1. Structure of human RRP6. (B) Overall structural comparison of human hR6CAT in cartoon (C) Overall structure of yR6CA.

Fig 1. Structure of human RRP6. (B) Overall structural comparison of human hR6CAT in cartoon (C) Overall structure of yR6CA.
  • Januszyk K, Liu Q, Lima CD

  • RNA. 2011 Aug;17(8):1566-77.

2011-09-22

Fig 1c. Deriving an “FDG uptake” metabolic gene expression signature. C. clinical datasets. Left, tumor FDG uptake in 18 breast cancer patients. Right, FDG-PET scan and Brain MRI in a patient with anaplastic astrocytoma.

Fig 1c. Deriving an “FDG uptake” metabolic gene expression signature. C. clinical datasets. Left, tumor FDG uptake in 18 breast cancer patients. Right, FDG-PET scan and Brain MRI in a patient with anaplastic astrocytoma.
  • Palaskas N, Larson SM, Schultz N, Komisopoulou E, Wong J, Rohle D, Campos C, Yannuzzi N, Osborne JR, Linkov I, Kastenhuber ER, Taschereau R, Plaisier SB, Tran C, Heguy A, Wu H, Sander C, Phelps ME, Brennan C, Port E, Huse JT, Graeber TG, Mellinghoff IK

  • Cancer Res. 2011 Aug 1;71(15):5164-5174.

2011-09-21

Fig 1. Axial slice of stereotactic body radiotherapy radiation plan. The 50% isodose line is in light blue, the 75% isodose line is in green, and the 95% isodose line is in yellow. The planning target volume is contoured in red, and the internal target volume is in dark blue. Normal structures are labeled. Du = Duodenum.

Fig 1. Axial slice of stereotactic body radiotherapy radiation plan. The 50% isodose line is in light blue, the 75% isodose line is in green, and the 95% isodose line is in yellow. The planning target volume is contoured in red, and the internal target volume is in dark blue. Normal structures are labeled. Du = Duodenum.
  • Schellenberg D, Kim J, Christman-Skieller C, Chun CL, Columbo LA, Ford JM, Fisher GA, Kunz PL, Van Dam J, Quon A, Desser TS, Norton J, Hsu A, Maxim PG, Xing L, Goodman KA, Chang DT, Koong AC

  • Int J Radiat Oncol Biol Phys. 2011 Sep 1;81(1):181-8.

2011-09-20

Fig 4. Inhibition of p300 or lysine acetylation blocks leukemogenesis by inhibiting cell growth of A-E–activated target genes. (D) A hypothetical model showing how p300, and acetylation of A-E by p300, might cooperate to induce leukemia.

Fig 4. Inhibition of p300 or lysine acetylation blocks leukemogenesis by inhibiting cell growth of A-E–activated target genes. (D) A hypothetical model showing how p300, and acetylation of A-E by p300, might cooperate to induce leukemia.
  • Wang L, Gural A, Sun XJ, Zhao X, Perna F, Huang G, Hatlen MA, Vu L, Liu F, Xu H, Asai T, Xu H, Deblasio T, Menendez S, Voza F, Jiang Y, Cole PA, Zhang J, Melnick A, Roeder RG, Nimer SD

  • Science. 2011 Aug 5;333(6043):765-9.

2011-09-19

Fig 5. A10ΔEC mice develop intestinal polyps.

Fig 5. A10ΔEC mice develop intestinal polyps.
  • Glomski K, Monette S, Manova K, De Strooper B, Saftig P, Blobel CP

  • Blood. 2011 Jul 28;118(4):1163-74.

2011-09-16

Fig 8. Arf deficiency provokes elevated and persistent γ-H2AX foci.

Fig 8. Arf deficiency provokes elevated and persistent γ-H2AX foci.
  • Churchman ML, Roig I, Jasin M, Keeney S, Sherr CJ

  • PLoS Genet. 2011 Jul;7(7):e1002157.
Open Access button

2011-09-15

Fig 1a. Regional association plot of the 6q21 locus. The –log (P value) for SNPs in this region is shown with respect to genomic position. Genotyped SNPs are in red; imputed SNPs are in black.

Fig 1a. Regional association plot of the 6q21 locus. The –log (P value) for SNPs in this region is shown with respect to genomic position. Genotyped SNPs are in red; imputed SNPs are in black.
  • Best T, Li D, Skol AD, Kirchhoff T, Jackson SA, Yasui Y, Bhatia S, Strong LC, Domchek SM, Nathanson KL, Olopade OI, Huang RS, Mack TM, Conti DV, Offit K, Cozen W, Robison LL, Onel K

  • Nat Med. 2011 Jul 24;17(8):941-3.

2011-09-14

Fig. 1 Patient example of laser interstitial thermal therapy.

Fig. 1 Patient example of laser interstitial thermal therapy.
  • Sherman JH, Hoes K, Marcus J, Komotar RJ, Brennan CW, Gutin PH

  • Curr Neurol Neurosci Rep. 2011 Jun;11(3):313-9.

2011-09-13

Fig 2. Best response (%) in target lesions, not available for 5 patients (4 inevaluable and 1 with clinical PD). PD, progressive disease.

Fig 2. Best response (%) in target lesions, not available for 5 patients (4 inevaluable and 1 with clinical PD). PD, progressive disease.
  • Modi S, Stopeck A, Linden H, Solit D, Chandarlapaty S, Rosen N, D'Andrea G, Dickler M, Moynahan ME, Sugarman S, Ma W, Patil S, Norton L, Hannah AL, Hudis C

  • Clin Cancer Res. 2011 Aug 1;17(15):5132-9.

2011-09-12

Fig. 1 An evolving view of the pathogenesis of diffuse gliomas

Fig. 1 An evolving view of the pathogenesis of diffuse gliomas
  • Brennan C

  • Curr Neurol Neurosci Rep. 2011 Jun;11(3):291-7.

2011-09-09

Fig 1b. 2.5×105 B16 tumor cells were suspended in matrigel and inoculated into WT C57B/6 mice. Tumors and TDLN were isolated and assessed for immune cell percentages to determine the peak of tumor infiltration time.

Fig 1b. 2.5×105 B16 tumor cells were suspended in matrigel and inoculated into WT C57B/6 mice. Tumors and TDLN were isolated and assessed for immune cell percentages to determine the peak of tumor infiltration time.
  • Schaer DA, Li Y, Merghoub T, Rizzuto GA, Shemesh A, Cohen AD, Li Y, Avogadri F, Toledo-Crow R, Houghton AN, Wolchok JD

  • PLoS One. 2011;6(6):e21214.
Open Access button

2011-09-08

Fig 1. Numeracy assessment: percent correct responses to numeracy questions (N = 120).

Fig 1. Numeracy assessment: percent correct responses to numeracy questions (N = 120).
  • Brown SM, Culver JO, Osann KE, Macdonald DJ, Sand S, Thornton AA, Grant M, Bowen DJ, Metcalfe KA, Burke HB, Robson ME, Friedman S, Weitzel JN

  • Patient Educ Couns. 2011 Apr;83(1):92-8.

2011-09-07

Fig 1c. Pie charts of the functional class distribution of genes that were upregulated 1.5 fold in site(+) but not in site(−) cultures following ATc treatment for 45 minutes, as compared to T = 0.

Fig 1c. Pie charts of the functional class distribution of genes that were upregulated 1.5 fold in site(+) but not in site(−) cultures following ATc treatment for 45 minutes, as compared to T = 0.
  • Stallings CL, Chu L, Li LX, Glickman MS

  • PLoS One. 2011;6(7):e21807.
Open Access button

2011-09-06

Fig 1. Schematic of capture strategy.

Fig 1. Schematic of capture strategy.
  • Wu J, Matthaei H, Maitra A, Dal Molin M, Wood LD, Eshleman JR, Goggins M, Canto MI, Schulick RD, Edil BH, Wolfgang CL, Klein AP, Diaz LA Jr, Allen PJ, Schmidt CM, Kinzler KW, Papadopoulos N, Hruban RH, Vogelstein B

  • Sci Transl Med. 2011 Jul 20;3(92):92ra66.

2011-09-02

Fig 4. Non-invasive imaging of ALP activity in rat tibia cortical bone.

Fig 4. Non-invasive imaging of ALP activity in rat tibia cortical bone.
  • Gade TP, Motley MW, Beattie BJ, Bhakta R, Boskey AL, Koutcher JA, Mayer-Kuckuk P

  • PLoS One. 2011;6(7):e22608.
Open Access button

2011-09-01

Fig 1. Growth of C. bovis on Columbia agar with 5% sheep blood. The small and large colony-types are distinguishable, measuring approximately 1 mm and 2 mm, respectively, in diameter.

Fig 1. Growth of C. bovis on Columbia agar with 5% sheep blood. The small and large colony-types are distinguishable, measuring approximately 1 mm and 2 mm, respectively, in diameter.
  • Burr HN, Lipman NS, White JR, Zheng J, Wolf FR

  • J Am Assoc Lab Anim Sci. 2011 May;50(3):378-88.

2011-08-31

Fig 2B. Crystal Structures of PHDUHRF1 Bound to H3(1-9) and H3(1-9)K4me3 Peptides.

Fig 2B. Crystal Structures of PHDUHRF1 Bound to H3(1-9) and H3(1-9)K4me3 Peptides.
  • Rajakumara E, Wang Z, Ma H, Hu L, Chen H, Lin Y, Guo R, Wu F, Li H, Lan F, Shi YG, Xu Y, Patel DJ, Shi Y

  • Mol Cell. 2011 Jul 22;43(2):275-84.

2011-08-30

Fig 3d-f. Malignant cells expressed green fluorescence under the enhanced EGFP filter.

Fig 3d-f. Malignant cells expressed green fluorescence under the enhanced EGFP filter.
  • Adusumilli PS, Gholami S, Chun YS, Mullerad M, Chan MK, Yu Z, Ben-Porat L, Rusch VW, Fong Y

  • Mol Med. 2011;17(7-8):628-34.

2011-08-29

Fig 1b. A two-strain bacterial aggregate detected on a bean leaf surface.

Fig 1b. A two-strain bacterial aggregate detected on a bean leaf surface.
  • Mitri S, Xavier JB, Foster KR

  • Proc Natl Acad Sci U S A. 2011 Jun 28;108 Suppl 2:10839-46.

2011-08-26

Fig 1. Myc controls multiple signaling pathways.

Fig 1. Myc controls multiple signaling pathways.
  • Mainwaring LA, Bhatia B, Kenney AM

  • Oncotarget. 2010 Jun;1(2):86-8.
Open Access button

2011-08-25

Fig 5a. Individual dots correspond to unique genes with a change in expression greater than 1.2 fold between WT and Rex1−/− primary germ cells. Semi-quantitative RT-PCR analysis of primary germ cell cDNA and mES cells

Fig 5a. Individual dots correspond to unique genes with a change in expression greater than 1.2 fold between WT and Rex1−/− primary germ cells. Semi-quantitative RT-PCR analysis of primary germ cell cDNA and mES cells
  • Rezende NC, Lee MY, Monette S, Mark W, Lu A, Gudas LJ

  • Dev Biol. 2011 Aug 15;356(2):370-82.

2011-08-24

Fig 1B. Key catalytic residues for G9a-mediated methylation (PDB 2O8J).

Fig 1B. Key catalytic residues for G9a-mediated methylation (PDB 2O8J).
  • Islam K, Zheng W, Yu H, Deng H, Luo M

  • ACS Chem Biol. 2011 Jul 15;6(7):679-84.

2011-08-23

The lack of patient input was our main concern with the BCTOS, which otherwise looks to be a psychometrically sound PRO measure.

The lack of patient input was our main concern with the BCTOS, which otherwise looks to be a psychometrically sound PRO measure.
  • Chen CM, Klassen AF, Cano SJ, Pusic AL

  • Breast J. 2011 Jul;17(4):443.

2011-08-22

Fig 2A. Stereo diagram of interactions between Mce and CTD.

Fig 2A. Stereo diagram of interactions between Mce and CTD.
  • Ghosh A, Shuman S, Lima CD

  • Mol Cell. 2011 Jul 22;43(2):299-310.

2011-08-19

Fig 3A. Structures of fixed and movable jaw domains.

Fig 3A. Structures of fixed and movable jaw domains.
  • Imasaki T, Calero G, Cai G, Tsai KL, Yamada K, Cardelli F, Erdjument-Bromage H, Tempst P, Berger I, Kornberg GL, Asturias FJ, Kornberg RD, Takagi Y

  • Nature. 2011 Jul 3;475(7355):240-3.

2011-08-18

Fig 2. Mean fellow participation score, by quarter and by attending physician. Transfer of responsibility to trainee operators is depicted by outward movement of participation scores on graph from one quarter to next.

Fig 2. Mean fellow participation score, by quarter and by attending physician. Transfer of responsibility to trainee operators is depicted by outward movement of participation scores on graph from one quarter to next.
  • Thornton RH, Erinjeri JP, Brody LA, Solomon SB

  • AJR Am J Roentgenol. 2011 Jun;196(6):W844-8.

2011-08-17

Fig 1. The overall structure of the ID complex. (A) View looking into the interior of the troughlike structure.

Fig 1. The overall structure of the ID complex. (A) View looking into the interior of the troughlike structure.
  • Joo W, Xu G, Persky NS, Smogorzewska A, Rudge DG, Buzovetsky O, Elledge SJ, Pavletich NP

  • Science. 2011 Jul 15;333(6040):312-6.

2011-08-16

Fig 1. Expression of CUL4A and CUL4B in developing and adult testes.

Fig 1. Expression of CUL4A and CUL4B in developing and adult testes.
  • Yin Y, Lin C, Kim ST, Roig I, Chen H, Liu L, Veith GM, Jin RU, Keeney S, Jasin M, Moley K, Zhou P, Ma L

  • Dev Biol. 2011 Aug 1;356(1):51-62.

2011-08-15

Fig 1. A Minimal Bacterial Community that Establishes a Balance between Pro- and Anti-inflammatory T Cells in the Gut.

Fig 1. A Minimal Bacterial Community that Establishes a Balance between Pro- and Anti-inflammatory T Cells in the Gut.
  • Rudensky AY, Chervonsky AV

  • Immunity. 2011 May 27;34(5):697-9.

2011-08-12

Fig 1. Interface of the ChVLig OB and latch domains with nicked DNA.

Fig 1. Interface of the ChVLig OB and latch domains with nicked DNA.
  • Samai P, Shuman S

  • J Biol Chem. 2011 Jun 24;286(25):22642-52.

2011-08-11

Fig 2. Pooled library screen for oncogenic miRNAs. (a) Schematic of the screening protocol: the primary screen selected for bypass of oncogene-induced apoptosis and the secondary screen selected for lymphocyte proliferation in the absence of IL-3.

Fig 2. Pooled library screen for oncogenic miRNAs. (a) Schematic of the screening protocol: the primary screen selected for bypass of oncogene-induced apoptosis and the secondary screen selected for lymphocyte proliferation in the absence of IL-3.
  • Mavrakis KJ, Van Der Meulen J, Wolfe AL, Liu X, Mets E, Taghon T, Khan AA, Setti M, Rondou P, Vandenberghe P, Delabesse E, Benoit Y, Socci NB, Leslie CS, Van Vlierberghe P, Speleman F, Wendel HG

  • Nat Genet. 2011 Jun 5;43(7):673-8.

2011-08-10

Hopelessness has become an increasingly important construct in palliative care research, yet concerns exist regarding the utility of existing measures when applied to patients with a terminal illness.

Hopelessness has become an increasingly important construct in palliative care research, yet concerns exist regarding the utility of existing measures when applied to patients with a terminal illness.
  • Rosenfeld B, Pessin H, Lewis C, Abbey J, Olden M, Sachs E, Amakawa L, Kolva E, Brescia R, Breitbart W

  • Psychol Assess. 2011 Jun;23(2):325-36.

2011-08-09

Fig 2. Overall survival for FOLFOX4/FOLFOX4-placebo/FOLFOX4-bevacizumab vs XELOX/XELOX-placebo/XELOX-bevacizumab (A), FOLFOX4/FOLFOX4-placebo vs XELOX/XELOX-placebo (B), FOLFOX4-bevacizumab vs XELOX-bevacizumab (C) and FOLFOX4 vs XELOX (D) (ITT population).

Fig 2. Overall survival for FOLFOX4/FOLFOX4-placebo/FOLFOX4-bevacizumab vs XELOX/XELOX-placebo/XELOX-bevacizumab (A), FOLFOX4/FOLFOX4-placebo vs XELOX/XELOX-placebo (B), FOLFOX4-bevacizumab vs XELOX-bevacizumab (C) and FOLFOX4 vs XELOX (D) (ITT population).
  • Cassidy J, Clarke S, Díaz-Rubio E, Scheithauer W, Figer A, Wong R, Koski S, Rittweger K, Gilberg F, Saltz L

  • Br J Cancer. 2011 Jun 28;105(1):58-64.

2011-08-09

Fig 1. Immunohistochemical staining of invasive ductal breast carcinoma for CT antigens in BRCA-1-positive patient (Case 108, ×10): A) HE staining displaying area of invasive ductal carcinoma of the mammary gland.

Fig 1. Immunohistochemical staining of invasive ductal breast carcinoma for CT antigens in BRCA-1-positive patient (Case 108, ×10): A) HE staining displaying area of invasive ductal carcinoma of the mammary gland.
  • Adams S, Greeder L, Reich E, Shao Y, Fosina D, Hanson N, Tassello J, Singh B, Spagnoli GC, Demaria S, Jungbluth AA

  • Cancer Immunol Immunother. 2011 Jul;60(7):999-1007.

2011-08-08

Fig 2. Whole body retention of radioactivity in female NIH Swiss mice (n≥3) following i.v. administration of various chemical forms of 89Zr (note the axis break).

Fig 2. Whole body retention of radioactivity in female NIH Swiss mice (n≥3) following i.v. administration of various chemical forms of 89Zr (note the axis break).
  • Abou DS, Ku T, Smith-Jones PM

  • Nucl Med Biol. 2011 Jul;38(5):675-81.

2011-08-05

Fig 2. Model of FESAHA bound to the active site of HDLP (based on the crystal structure published by Finnin et al. [32]) [46] W.L. Delano, The PyMOL Molecular Graphics System, Delano Scientific, San Carlos (Calif) (2002).[46].

Fig 2. Model of FESAHA bound to the active site of HDLP (based on the crystal structure published by Finnin et al. [32]) [46] W.L. Delano, The PyMOL Molecular Graphics System, Delano Scientific, San Carlos (Calif) (2002).[46].
  • Zeglis BM, Pillarsetty N, Divilov V, Blasberg RA, Lewis JS

  • Nucl Med Biol. 2011 Jul;38(5):683-96.

2011-08-04

Fig 4. Integrated gene map showing BAP1 losses and mutations in relation to other identified genomic events in all 53 samples.

Fig 4. Integrated gene map showing BAP1 losses and mutations in relation to other identified genomic events in all 53 samples.
  • Bott M, Brevet M, Taylor BS, Shimizu S, Ito T, Wang L, Creaney J, Lake RA, Zakowski MF, Reva B, Sander C, Delsite R, Powell S, Zhou Q, Shen R, Olshen A, Rusch V, Ladanyi M

  • Nat Genet. 2011 Jun 5;43(7):668-72.

2011-08-03

Fig 3. Structure of the YAP WW1–WW2 pair bound to the Smad1 linker. (C) Detailed view of the refined structure of the YAP WW2 domain (green) bound to the PY motif region of Smad1 (gray), with the key residues indicated.

Fig 3. Structure of the YAP WW1–WW2 pair bound to the Smad1 linker. (C) Detailed view of the refined structure of the YAP WW2 domain (green) bound to the PY motif region of Smad1 (gray), with the key residues indicated.
  • Aragón E, Goerner N, Zaromytidou AI, Xi Q, Escobedo A, Massagué J, Macias MJ

  • Genes Dev. 2011 Jun 15;25(12):1275-88.
Open Access button

2011-08-02

Fig 1. b A 51-year-old man with systemic AL amyloidosis with a LVEF of 65%. The markedly abnormal average global 2D speckle strain was −11%.

Fig 1. b A 51-year-old man with systemic AL amyloidosis with a LVEF of 65%. The markedly abnormal average global 2D speckle strain was −11%.
  • Raikhelkar JK, Steingart RM, Chen CL

  • Herz. 2011 Jun;36(4):333-339.

2011-08-01

Fig 4 (A). Follow-up after RFA for primary non–small cell lung adenocarcinoma. 18F-FDG PET/CT image at 4.5 mo after RFA. (A) shows typical early pattern of ring of low-grade (SUV, 3.0) metabolic activity (arrow), and 18F-FDG PET/CT image at 9 mo after RFA.

Fig 4 (A). Follow-up after RFA for primary non–small cell lung adenocarcinoma. 18F-FDG PET/CT image at 4.5 mo after RFA. (A) shows typical early pattern of ring of low-grade (SUV, 3.0) metabolic activity (arrow), and 18F-FDG PET/CT image at 9 mo after RFA.
  • Singnurkar A, Solomon SB, Gönen M, Larson SM, Schöder H

  • J Nucl Med. 2010 Dec;51(12):1833-40.

2011-07-29

Fig 1. Mutations and Cytogenetic Abnormalities in 223 Samples with at Least One Mutation.

Fig 1. Mutations and Cytogenetic Abnormalities in 223 Samples with at Least One Mutation.
  • Bejar R, Stevenson K, Abdel-Wahab O, Galili N, Nilsson B, Garcia-Manero G, Kantarjian H, Raza A, Levine RL, Neuberg D, Ebert BL

  • N Engl J Med. 2011 Jun 30;364(26):2496-506.

2011-07-28

Fig 4. 64Cu-J591 PET detects up-regulation of PSMA expression in prostate cancer xenografts in response to androgen deprivation therapies.

Fig 4. 64Cu-J591 PET detects up-regulation of PSMA expression in prostate cancer xenografts in response to androgen deprivation therapies.
  • Evans MJ, Smith-Jones PM, Wongvipat J, Navarro V, Kim S, Bander NH, Larson SM, Sawyers CL

  • Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9578-82.
Open Access button

2011-07-28

Fig 1. Anteroposterior view of eyelash overgrowth.

Fig 1. Anteroposterior view of eyelash overgrowth.
  • Morris LG, Hochster HS, Delacure MD

  • Curr Oncol. 2011 Jun;18(3):145-6.
Open Access button

2011-07-27

Fig 2. miR-33b regulates human hepatic β-oxidation and lipid homeostasis in Drosophila. (G) Neutral lipid accumulation in the fat body of Cg > DsRed and Cg > DsRed-miR-33 stained with Bodipy (green), Hoechst 33352 (blue), and the transgene (red).

Fig 2. miR-33b regulates human hepatic β-oxidation and lipid homeostasis in Drosophila. (G) Neutral lipid accumulation in the fat body of Cg > DsRed and Cg > DsRed-miR-33 stained with Bodipy (green), Hoechst 33352 (blue), and the transgene (red).
  • Dávalos A, Goedeke L, Smibert P, Ramírez CM, Warrier NP, Andreo U, Cirera-Salinas D, Rayner K, Suresh U, Pastor-Pareja JC, Esplugues E, Fisher EA, Penalva LO, Moore KJ, Suárez Y, Lai EC, Fernández-Hernando C

  • Proc Natl Acad Sci U S A. 2011 May 31;108(22):9232-7.

2011-07-26

Fig 1. The Mu-based integration site recovery method. D) The Mu-mediated integration site recovery method.

Fig 1. The Mu-based integration site recovery method. D) The Mu-mediated integration site recovery method.
  • Brady T, Roth SL, Malani N, Wang GP, Berry CC, Leboulch P, Hacein-Bey-Abina S, Cavazzana-Calvo M, Papapetrou EP, Sadelain M, Savilahti H, Bushman FD

  • Nucleic Acids Res. 2011 Jun 1;39(11):e72.
Open Access button

2011-07-25

Fig 2. 77-year-old man with pancreatic carcinoma and unsuspected primary T3N0 colon carcinoma with intussusception into transverse colon. Intussusception was present at surgery, and there were two masses originating from cecum (7 cm) and right colon 10 cm distal to this (6 cm).

Fig 2. 77-year-old man with pancreatic carcinoma and unsuspected primary T3N0 colon carcinoma with intussusception into transverse colon. Intussusception was present at surgery, and there were two masses originating from cecum (7 cm) and right colon 10 cm distal to this (6 cm).
  • Gollub MJ

  • AJR Am J Roentgenol. 2011 May;196(5):W580-5.

2011-07-22

Fig 2. Bar graph of distribution of content satisfaction ratings for conventional and structured reports.

Fig 2. Bar graph of distribution of content satisfaction ratings for conventional and structured reports.
  • Schwartz LH, Panicek DM, Berk AR, Li Y, Hricak H

  • Radiology. 2011 Jul;260(1):174-81.

2011-07-22

Fig 5(C). Optimal protection to M. tuberculosis requires a Th-1 lineage population, yet is independent of T-bet. Histogram plots following intracellular staining for the indicated transcription factors. The gate marks the frequencies of RORγt bright cells.

Fig 5(C). Optimal protection to M. tuberculosis requires a Th-1 lineage population, yet is independent of T-bet. Histogram plots following intracellular staining for the indicated transcription factors. The gate marks the frequencies of RORγt bright cells.
  • Gallegos AM, van Heijst JW, Samstein M, Su X, Pamer EG, Glickman MS

  • PLoS Pathog. 2011 May;7(5):e1002052.
Open Access button

2011-07-21

Fig 1b. T1-weighted fat-suppressed contrast-enhanced subtraction MR images show different right breasts with (b) mild BPE.

Fig 1b. T1-weighted fat-suppressed contrast-enhanced subtraction MR images show different right breasts with (b) mild BPE.
  • King V, Brooks JD, Bernstein JL, Reiner AS, Pike MC, Morris EA

  • Radiology. 2011 Jul;260(1):50-60.

2011-07-20

Fig 2. Kaplan-Meier analyses by treatment group (thin gold lines are simultaneous 95% confidence bands for docetaxel arm, thin blue lines are simultaneous 95% confidence bands for docetaxel + high-dose calcitriol [DN-101] arm).

Fig 2. Kaplan-Meier analyses by treatment group (thin gold lines are simultaneous 95% confidence bands for docetaxel arm, thin blue lines are simultaneous 95% confidence bands for docetaxel + high-dose calcitriol [DN-101] arm).
  • Scher HI, Jia X, Chi K, de Wit R, Berry WR, Albers P, Henick B, Waterhouse D, Ruether DJ, Rosen PJ, Meluch AA, Nordquist LT, Venner PM, Heidenreich A, Chu L, Heller G

  • J Clin Oncol. 2011 Jun 1;29(16):2191-8.

2011-07-19

Fig. 3. Influence of retinoic acid (RA).

Fig. 3. Influence of retinoic acid (RA).
  • Bothe I, Tenin G, Oseni A, Dietrich S

  • Development. 2011 Jul;138(13):2807-21.

2011-07-18

Fig 1. Diagram of the open 2-compartment model with the two pharmacokinetic parameters, Ktrans and kep.

Fig 1. Diagram of the open 2-compartment model with the two pharmacokinetic parameters, Ktrans and kep.
  • Franiel T, Hamm B, Hricak H

  • Eur Radiol. 2011 Mar;21(3):616-26.

2011-07-15

Fig 2. Anatomical location of NKT cells in mesenteric lymph node and spleen.

Fig 2. Anatomical location of NKT cells in mesenteric lymph node and spleen.
  • Thomas SY, Scanlon ST, Griewank KG, Constantinides MG, Savage AK, Barr KA, Meng F, Luster AD, Bendelac A

  • J Exp Med. 2011 Jun 6;208(6):1179-88.

2011-07-14

Fig 4c. Full-length (FL) Bax co-localizes with MCRMs induced by exogenous C16-ceramide.

Fig 4c. Full-length (FL) Bax co-localizes with MCRMs induced by exogenous C16-ceramide.
  • Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao WC, Yin X, Ragupathi G, Ehleiter D, Gulbins E, Zhai D, Reed JC, Haimovitz-Friedman A, Fuks Z, Kolesnick R

  • PLoS One. 2011;6(6):e19783.
Open Access button

2011-07-13

Fig 1. The concept of self-seeding that explains cancer growth and metastasis.

Fig 1. The concept of self-seeding that explains cancer growth and metastasis.
  • Comen E, Norton L, Massagué J

  • Nat Rev Clin Oncol. 2011 Jun;8(6):369-77.

2011-07-12

Fig 1. Current Methods for Reprogramming Cell Fate.

Fig 1. Current Methods for Reprogramming Cell Fate.
  • Chambers SM, Studer L

  • Cell. 2011 Jun 10;145(6):827-30.

2011-07-11

Fig 2a. AP radiograph of left knee shows multiple horizontal sclerotic bands (arrowheads) and club-shaped deformity of distal left femoral and proximal tibial metaphyses 10 months after completion of pamidronate therapy.

Fig 2a. AP radiograph of left knee shows multiple horizontal sclerotic bands (arrowheads) and club-shaped deformity of distal left femoral and proximal tibial metaphyses 10 months after completion of pamidronate therapy.
  • Price AP, Abramson SJ, Hwang S, Chou A, Bartolotta R, Meyers P, Katz DS

  • Pediatr Radiol. 2011 Apr;41(4):451-8.

2011-07-08

Fig 1. Paraganglioma of the larynx.

Fig 1. Paraganglioma of the larynx.
  • Lewis JS Jr, Ferlito A, Gnepp DR, Rinaldo A, Devaney KO, Silver CE, Travis WD

  • Laryngoscope. 2011 May 6.

2011-07-07

Fig 2. Marked alteration in the epidermal maturation showing irregular epidermal acanthosis, hyperkeratosis with intense parakeratosis, pale keratinocytes, hypogranulosis, and papillomatosis.

Fig 2. Marked alteration in the epidermal maturation showing irregular epidermal acanthosis, hyperkeratosis with intense parakeratosis, pale keratinocytes, hypogranulosis, and papillomatosis.
  • Concepción GR, Belen R, Luis RP

  • Am J Dermatopathol. 2011 Jun;33(4):410-2.

2011-07-06

Fig 7. Centriole duplication and segregation cycle.

Fig 7. Centriole duplication and segregation cycle.
  • Wang WJ, Soni RK, Uryu K, Bryan Tsou MF

  • J Cell Biol. 2011 May 16;193(4):727-39.

2011-07-05

Fig 1. Survival curves by number of mitoses per millimeter squared.

Fig 1. Survival curves by number of mitoses per millimeter squared.
  • Thompson JF, Soong SJ, Balch CM, Gershenwald JE, Ding S, Coit DG, Flaherty KT, Gimotty PA, Johnson T, Johnson MM, Leong SP, Ross MI, Byrd DR, Cascinelli N, Cochran AJ, Eggermont AM, McMasters KM, Mihm MC Jr, Morton DL, Sondak VK

  • J Clin Oncol. 2011 Jun 1;29(16):2199-205.

2011-07-01

Fig 5B. Enhanced replication of NDV in A549–Bcl-xL cells is associated with enhanced syncytium formation. (B) A549-neo and A549–Bcl-xL cells were infected with NDV (LS)-GFP at an MOI of 0.01, fixed, stained for NDV (green), and assessed for syncytium formation by confocal microscopy. Nuclei were stained with DAPI (blue).

Fig 5B. Enhanced replication of NDV in A549–Bcl-xL cells is associated with enhanced syncytium formation. (B) A549-neo and A549–Bcl-xL cells were infected with NDV (LS)-GFP at an MOI of 0.01, fixed, stained for NDV (green), and assessed for syncytium formation by confocal microscopy. Nuclei were stained with DAPI (blue).
  • Mansour M, Palese P, Zamarin D

  • J Virol. 2011 Jun;85(12):6015-23.