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2011-07-01

Fig 5B. Enhanced replication of NDV in A549–Bcl-xL cells is associated with enhanced syncytium formation. (B) A549-neo and A549–Bcl-xL cells were infected with NDV (LS)-GFP at an MOI of 0.01, fixed, stained for NDV (green), and assessed for syncytium formation by confocal microscopy. Nuclei were stained with DAPI (blue).

Fig 5B. Enhanced replication of NDV in A549–Bcl-xL cells is associated with enhanced syncytium formation. (B) A549-neo and A549–Bcl-xL cells were infected with NDV (LS)-GFP at an MOI of 0.01, fixed, stained for NDV (green), and assessed for syncytium formation by confocal microscopy. Nuclei were stained with DAPI (blue).
  • Mansour M, Palese P, Zamarin D

  • J Virol. 2011 Jun;85(12):6015-23.

2011-06-30

Fig 1. Rates of contralateral prophylactic mastectomy (CPM) and use of magnetic resonance imaging (MRI) at diagnosis by year of surgery.

Fig 1. Rates of contralateral prophylactic mastectomy (CPM) and use of magnetic resonance imaging (MRI) at diagnosis by year of surgery.
  • King TA, Sakr R, Patil S, Gurevich I, Stempel M, Sampson M, Morrow M

  • J Clin Oncol. 2011 Jun 1;29(16):2158-64.

2011-06-29

Fig 1d. PI3K-pathway inhibition induces ERK phosphorylation in HER2-overexpressing cells.Immunohistochemistry (IHC) of BT474-trastuzumab resistant (BT474-Tr) xenografts treated with BEZ235 (40 mg/kg, 4 × QD) with the indicated phospho-proteins. IHC pictures are representative of the 6-h time point.

Fig 1d. PI3K-pathway inhibition induces ERK phosphorylation in HER2-overexpressing cells.Immunohistochemistry (IHC) of BT474-trastuzumab resistant (BT474-Tr) xenografts treated with BEZ235 (40 mg/kg, 4 × QD) with the indicated phospho-proteins. IHC pictures are representative of the 6-h time point.
  • Serra V, Scaltriti M, Prudkin L, Eichhorn PJ, Ibrahim YH, Chandarlapaty S, Markman B, Rodriguez O, Guzman M, Rodriguez S, Gili M, Russillo M, Parra JL, Singh S, Arribas J, Rosen N, Baselga J

  • Oncogene. 2011 Jun 2;30(22):2547-57.

2011-06-28

Dr. Bridge is one of the most highly respected figures in cancer cytogenetics and is also recognized as a great educator, using her combined expertise in pathology, cancer cytogenetics, and research to spread learning and knowledge.

Dr. Bridge is one of the most highly respected figures in cancer cytogenetics and is also recognized as a great educator, using her combined expertise in pathology, cancer cytogenetics, and research to spread learning and knowledge.
  • Ladanyi M

  • Am J Surg Pathol. 2011 Mar;35(3):455-6.

2011-06-27

Fig 2. Crystal structure of the SUVH5 SRA domain bound to fully methylated CG DNA.

Fig 2. Crystal structure of the SUVH5 SRA domain bound to fully methylated CG DNA.
  • Rajakumara E, Law JA, Simanshu DK, Voigt P, Johnson LM, Reinberg D, Patel DJ, Jacobsen SE

  • Genes Dev. 2011 Jan 15;25(2):137-52.

2011-06-24

Fig 3. Detectable cTnI and CRP values for all patients (n = 95). A, cTnI and B, CRP. dd AC, dose-dense doxorubicin and cyclophosphamide; PTL, paclitaxel trastuzumab and lapatinib; TL, trastuzumab and lapatinib.

Fig 3. Detectable cTnI and CRP values for all patients (n = 95). A, cTnI and B, CRP. dd AC, dose-dense doxorubicin and cyclophosphamide; PTL, paclitaxel trastuzumab and lapatinib; TL, trastuzumab and lapatinib.
  • Morris PG, Chen C, Steingart R, Fleisher M, Lin N, Moy B, Come S, Sugarman S, Abbruzzi A, Lehman R, Patil S, Dickler M, McArthur HL, Winer E, Norton L, Hudis CA, Dang CT

  • Clin Cancer Res. 2011 May 15;17(10):3490-9.

2011-06-23

Fig 1. Angiographic images before (a) and after (b) bland embolization in a 22-year-old patient who was receiving treatment with growth and sex hormones.

Fig 1. Angiographic images before (a) and after (b) bland embolization in a 22-year-old patient who was receiving treatment with growth and sex hormones.
  • Deodhar A, Brody LA, Covey AM, Brown KT, Getrajdman GI

  • J Vasc Interv Radiol. 2011 Jun;22(6):795-9.

2011-06-22

Fig 1. (D) Cells from whole E7.5 or E8.5 embryos were FACS sorted to GFP(+) and GFP(−) populations. Left panel, Giemsa-stained cytospun cells from FACS sort. Scale bar, 20 μm. EryP-progenitor numbers were measured using a clonogenic assay. Virtually all progenitor activity was recovered in the GFP(+) population. Characteristic EryP colonies (right panels) showed red pigmentation (hemoglobin) and GFP fluorescence. Scale bar, 50 μm.

Fig 1. (D) Cells from whole E7.5 or E8.5 embryos were FACS sorted to GFP(+) and GFP(−) populations. Left panel, Giemsa-stained cytospun cells from FACS sort. Scale bar, 20 μm. EryP-progenitor numbers were measured using a clonogenic assay. Virtually all progenitor activity was recovered in the GFP(+) population. Characteristic EryP colonies (right panels) showed red pigmentation (hemoglobin) and GFP fluorescence. Scale bar, 50 μm.
  • Isern J, He Z, Fraser ST, Nowotschin S, Ferrer-Vaquer A, Moore R, Hadjantonakis AK, Schulz V, Tuck D, Gallagher PG, Baron MH

  • Blood. 2011 May 5;117(18):4924-34.

2011-06-21

Fig 4. For a representative axial slice, a CT image (A), an FACBC PET image (B), and a registered image (C) are shown.

Fig 4. For a representative axial slice, a CT image (A), an FACBC PET image (B), and a registered image (C) are shown.
  • Rice SL, Roney CA, Daumar P, Lewis JS

  • Semin Nucl Med. 2011 Jul;41(4):265-82.

2011-06-20

Fig 1. Computed tomographic image of neuroblastoma encasing the SMA.

Fig 1. Computed tomographic image of neuroblastoma encasing the SMA.
  • Rich BS, McEvoy MP, Kelly NE, Oh E, Abramson SJ, Price AP, Cheung NK, La Quaglia MP

  • J Pediatr Surg. 2011 Jan;46(1):103-7.

2011-06-16

Fig 1. (b) BrdU staining of a CML CD34+/G1/S/G2/M and CD34+/G0 quiescent fraction. Left panel: CML G1/S/G2/M cells. Right panel: CML G0 cells.

Fig 1. (b) BrdU staining of a CML CD34+/G1/S/G2/M and CD34+/G0 quiescent fraction. Left panel: CML G1/S/G2/M cells. Right panel: CML G0 cells.
  • Affer M, Dao S, Liu C, Olshen AB, Mo Q, Viale A, Lambek CL, Marr TG, Clarkson BD

  • J Oncol. 2011;2011:798592.

2011-06-15

Fig 1. Example of 99mTc-annexin A5 SPECT of human Crohn disease.

Fig 1. Example of 99mTc-annexin A5 SPECT of human Crohn disease.
  • Heneweer C, Grimm J

  • Pediatr Radiol. 2011 Feb;41(2):199-207.

2011-06-14

Graphical abstract: To our knowledge, this work represents the first reported semisynthesis of a receptor tyrosine kinase and provides a potentially general method for producing single-pass membrane proteins for structural and biochemical characterization.

Graphical abstract: To our knowledge, this work represents the first reported semisynthesis of a receptor tyrosine kinase and provides a potentially general method for producing single-pass membrane proteins for structural and biochemical characterization.
  • Singla N, Erdjument-Bromage H, Himanen JP, Muir TW, Nikolov DB

  • Chem Biol. 2011 Mar 25;18(3):361-71.

2011-06-13

Fig 1. Mean z-scores for Groups 1 and 2 on tests of attention and executive functions.

Fig 1. Mean z-scores for Groups 1 and 2 on tests of attention and executive functions.
  • Correa DD, Zhou Q, Thaler HT, Maziarz M, Hurley K, Hensley ML

  • Gynecol Oncol. 2010 Nov;119(2):366-9.

2011-06-10

Fig 1a. FISH image with the spectrum green fluorochrome showing melanoma with prominent gains in 11q13 (CCND1) (original magnification, ×1000).

Fig 1a. FISH image with the spectrum green fluorochrome showing melanoma with prominent gains in 11q13 (CCND1) (original magnification, ×1000).
  • Gerami P, Jewell SS, Pouryazdanparast P, Wayne JD, Haghighat Z, Busam KJ, Rademaker A, Morrison L

  • J Mol Diagn. 2011 May;13(3):352-8.

2011-06-09

Fig 1a. Perioperative bilirubin concentrations in the serum and drain fluid of patients after hepatic resection.

Fig 1a. Perioperative bilirubin concentrations in the serum and drain fluid of patients after hepatic resection.
  • Koch M, Garden OJ, Padbury R, Rahbari NN, Adam R, Capussotti L, Fan ST, Yokoyama Y, Crawford M, Makuuchi M, Christophi C, Banting S, Brooke-Smith M, Usatoff V, Nagino M, Maddern G, Hugh TJ, Vauthey JN, Greig P, Rees M, Nimura Y, Figueras J, Dematteo RP, Büchler MW, Weitz J

  • Surgery. 2011 May;149(5):680-8.

2011-06-08

Fig 2b. Cells are gated on CD4+TCRβ+CD44hi cells from the small intestine after anti-CD3 treatment.

Fig 2b. Cells are gated on CD4+TCRβ+CD44hi cells from the small intestine after anti-CD3 treatment.
  • Huber S, Gagliani N, Esplugues E, O'Connor W Jr, Huber FJ, Chaudhry A, Kamanaka M, Kobayashi Y, Booth CJ, Rudensky AY, Roncarolo MG, Battaglia M, Flavell RA

  • Immunity. 2011 Apr 22;34(4):554-65.

2011-06-07

Fig 2. A scanning magnification view demonstrates a broad melanocytic proliferation with its center of gravity in the reticular dermis.

Fig 2. A scanning magnification view demonstrates a broad melanocytic proliferation with its center of gravity in the reticular dermis.
  • McCalmont TH, Vemula S, Sands P, Bastian BC

  • J Cutan Pathol. 2011 Apr;38(4):324-6.

2011-06-06

Fig 1a. Handheld WiPOX device utilizes reflectance oximetry.

Fig 1a. Handheld WiPOX device utilizes reflectance oximetry.
  • Servais EL, Rizk NP, Oliveira L, Rusch VW, Bikson M, Adusumilli PS

  • Surg Endosc. 2011 May;25(5):1383-9.

2011-06-03

Fig. 1 Intraoperative view of the Gelport system with standard laparoscopic ports (upper panel), allowing palpation, ultrasonography, or immediate control of any major bleeding site if necessary

Fig. 1 Intraoperative view of the Gelport system with standard laparoscopic ports (upper panel), allowing palpation, ultrasonography, or immediate control of any major bleeding site if necessary
  • Gaujoux S, Kingham TP, Jarnagin WR, D'Angelica MI, Allen PJ, Fong Y

  • Surg Endosc. 2011 May;25(5):1489-94.

2011-06-02

Fig 4a. EGF induces K63-specific ubiquitination.

Fig 4a. EGF induces K63-specific ubiquitination.
  • Argenzio E, Bange T, Oldrini B, Bianchi F, Peesari R, Mari S, Di Fiore PP, Mann M, Polo S

  • Mol Syst Biol. 2011 Jan 18;7:462.
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2011-06-01

Fig 1.  The intratumor balance of effector and regulatory T cells (Treg).

Fig 1.  The intratumor balance of effector and regulatory T cells (Treg).
  • Quezada SA, Peggs KS, Simpson TR, Allison JP

  • Immunol Rev. 2011 May;241(1):104-18.

2011-05-31

Fig 1a. Increased circulating monocytes were identified as CD11b+Ly6Chi by flow cytometry. Flow cytometry plots are gated on CD45+ nucleated cells.

Fig 1a. Increased circulating monocytes were identified as CD11b+Ly6Chi by flow cytometry. Flow cytometry plots are gated on CD45+ nucleated cells.
  • Shi C, Jia T, Mendez-Ferrer S, Hohl TM, Serbina NV, Lipuma L, Leiner I, Li MO, Frenette PS, Pamer EG

  • Immunity. 2011 Apr 22;34(4):590-601.

2011-05-27

Fig 5. Axial computed tomography-based planning slice (left) through the planning target volume of a patient with intracranial tumor extension who developed temporal lobe necrosis as seen on magnetic resonance imaging (right).

Fig 5. Axial computed tomography-based planning slice (left) through the planning target volume of a patient with intracranial tumor extension who developed temporal lobe necrosis as seen on magnetic resonance imaging (right).
  • Bakst RL, Lee N, Pfister DG, Zelefsky MJ, Hunt MA, Kraus DH, Wolden SL

  • Int J Radiat Oncol Biol Phys. 2011 May 1;80(1):148-53.

2011-05-26

Fig 1a. Western blot analysis of protein isolated from vehicle- or Shh-treated CGNP primary cultures.

Fig 1a. Western blot analysis of protein isolated from vehicle- or Shh-treated CGNP primary cultures.
  • Mainwaring LA, Kenney AM

  • Oncogene. 2011 Apr 14;30(15):1784-97.

2011-05-25

Fig 2i. Representative H&E-stained sections of large bowel at the level of the ileocecal-colic junction from Foxp3CreIl10rafl/wt and Foxp3CreIl10rafl/fl mice.

Fig 2i. Representative H&E-stained sections of large bowel at the level of the ileocecal-colic junction from Foxp3CreIl10rafl/wt and Foxp3CreIl10rafl/fl mice.
  • Chaudhry A, Samstein RM, Treuting P, Liang Y, Pils MC, Heinrich JM, Jack RS, Wunderlich FT, Brüning JC, Müller W, Rudensky AY

  • Immunity. 2011 Apr 22;34(4):566-78.

2011-05-24

Fig 1. Cooperative social interactions that provide a population-level benefit often come at a cost to individual's cells.

Fig 1. Cooperative social interactions that provide a population-level benefit often come at a cost to individual's cells.
  • Xavier JB

  • Mol Syst Biol. 2011 Apr 12;7:483.
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2011-05-23

Fig 2a. An 18-year-old man with sphenoid mucocele. Axial T2WI demonstrates a fluid-filled and expanded sphenoid sinus.

Fig 2a. An 18-year-old man with sphenoid mucocele. Axial T2WI demonstrates a fluid-filled and expanded sphenoid sinus.
  • Lui YW, Dasari SB, Young RJ

  • AJNR Am J Neuroradiol. 2011 Apr;32(4):617-26.

2011-05-20

Fig 1a. Well-differentiated tumor in cytology.

Fig 1a. Well-differentiated tumor in cytology.
  • Travis WD, Rekhtman N

  • Semin Respir Crit Care Med. 2011 Feb;32(1):22-31.

2011-05-19

Fig 1. Major signaling pathways in uveal melanoma.

Fig 1. Major signaling pathways in uveal melanoma.
  • Patel M, Smyth E, Chapman PB, Wolchok JD, Schwartz GK, Abramson DH, Carvajal RD

  • Clin Cancer Res. 2011 Apr 15;17(8):2087-100.

2011-05-18

Fig 1. TGF-beta-1-GFP Knockin Mice Reveal Expression of TGF-beta-1 in Thymic and Peripheral T Cells

Fig 1. TGF-beta-1-GFP Knockin Mice Reveal Expression of TGF-beta-1 in Thymic and Peripheral T Cells
  • Gutcher I, Donkor MK, Ma Q, Rudensky AY, Flavell RA, Li MO

  • Immunity. 2011 Mar 25;34(3):396-408.

2011-05-17

Fig 1. Wild-type (WT) NKT cells (orange) exhibit an innate-like phenotype (eg., CD44/CD69), express NK1.1 and are mostly CD4-positive.

Fig 1. Wild-type (WT) NKT cells (orange) exhibit an innate-like phenotype (eg., CD44/CD69), express NK1.1 and are mostly CD4-positive.
  • Alonzo ES, Sant'angelo DB

  • Curr Opin Immunol. 2011 Apr;23(2):220-7.

2011-05-16

Fig 6a. Blocking mitochondrial PTP inhibits uPA/invasion. Mitochondrial PTP inhibitors block HGF/SF-mediated uPA activity in MDCK cells.

Fig 6a. Blocking mitochondrial PTP inhibits uPA/invasion. Mitochondrial PTP inhibitors block HGF/SF-mediated uPA activity in MDCK cells.
  • Xie Q, Wondergem R, Shen Y, Cavey G, Ke J, Thompson R, Bradley R, Daughtery-Holtrop J, Xu Y, Chen E, Omar H, Rosen N, Wenkert D, Xu HE, Vande Woude GF

  • Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4105-10.

2011-05-13

Fig 1. Proteolytic contributions from various stromal cells.

Fig 1. Proteolytic contributions from various stromal cells.
  • Mason SD, Joyce JA

  • Trends Cell Biol. 2011 Apr;21(4):228-37.

2011-05-12

Fig. 2. (A) Area of standard lymph node dissection (LND) and (B) proposed extended LND for prostate cancer by Mattei and colleagues approaching nodes extending along the common iliac vessels to the ureteric crossing.

Fig. 2. (A) Area of standard lymph node dissection (LND) and (B) proposed extended LND for prostate cancer by Mattei and colleagues approaching nodes extending along the common iliac vessels to the ureteric crossing.
  • Morikawa LK, Roach M 3rd

  • Int J Radiat Oncol Biol Phys 2011 may 1;80(1):6-16.

2011-05-11

Fig 1a. Identification of a CIMP by clustering of breast cancer samples.

Fig 1a. Identification of a CIMP by clustering of breast cancer samples.
  • Fang F, Turcan S, Rimner A, Kaufman A, Giri D, Morris LG, Shen R, Seshan V, Mo Q, Heguy A, Baylin SB, Ahuja N, Viale A, Massague J, Norton L, Vahdat LT, Moynahan ME, Chan TA

  • Sci Transl Med. 2011 Mar 23;3(75):75ra25.

2011-05-10

Fig. 1 Amplification of the oncogenic driver of ERK pathway activity confers resistance to MEK inhibitors.

Fig. 1 Amplification of the oncogenic driver of ERK pathway activity confers resistance to MEK inhibitors.
  • Poulikakos PI, Solit DB

  • Sci Signal. 2011 Mar 29;4(166):pe16.

2011-05-09

Fig 1c. Cell proliferation assay showing reduced proliferation in SCCRO−/− relative to SCCRO+/+ and SCCRO+/− MEFs. Retroviral delivery of SCCRO but not SCCRO-D241N rescued the proliferation defect in SCCRO−/− MEFs.

Fig 1c. Cell proliferation assay showing reduced proliferation in SCCRO−/− relative to SCCRO+/+ and SCCRO+/− MEFs. Retroviral delivery of SCCRO but not SCCRO-D241N rescued the proliferation defect in SCCRO−/− MEFs.
  • Huang G, Kaufman AJ, Ramanathan Y, Singh B

  • J Biol Chem. 2011 Mar 25;286(12):10297-304.

2011-05-06

Fig 4. Influence of high-resolution unit-recipient HLA match on sustained donor engraftment (n = 84).

Fig 4. Influence of high-resolution unit-recipient HLA match on sustained donor engraftment (n = 84).
  • Avery S, Shi W, Lubin M, Gonzales AM, Heller G, Castro-Malaspina H, Giralt S, Kernan NA, Scaradavou A, Barker JN

  • Blood. 2011 Mar 24;117(12):3277-85.

2011-05-05

Fig 3. Detection of pericytes in sarcoma archived material.

Fig 3. Detection of pericytes in sarcoma archived material.
  • Morozov A, Downey RJ, Healey J, Moreira AL, Lou E, Franceschino A, Dogan Y, Leung R, Edgar M, LaQuaglia M, Maki RG, Moore MA

  • Clin Cancer Res. 2010 Dec 1;16(23):5630-40.

2011-05-04

Fig 1A. The RtcB protein encoded by the E. coli rtcBA operon is an RNA ligase. Genetic organization of the E. coli rtc operon.

Fig 1A. The RtcB protein encoded by the E. coli rtcBA operon is an RNA ligase. Genetic organization of the E. coli rtc operon.
  • Tanaka N, Shuman S

  • J Biol Chem. 2011 Mar 11;286(10):7727-31.

2011-05-03

Fig 1b. c-KIT D816V mutation detected in bone marrow.

Fig 1b. c-KIT D816V mutation detected in bone marrow.
  • Park JH, Hedvat CV, Tallman MS

  • Blood. 2011 Mar 10;117(10):2775-7.

2011-05-02

Fig 1. Mutant EGFR oncogene dependence requires downregulation of the FAS-NF-κB pathway.

Fig 1. Mutant EGFR oncogene dependence requires downregulation of the FAS-NF-κB pathway.
  • Bivona TG, Hieronymus H, Parker J, Chang K, Taron M, Rosell R, Moonsamy P, Dahlman K, Miller VA, Costa C, Hannon G, Sawyers CL

  • Nature. 2011 Mar 24;471(7339):523-6.

2011-04-29

Fig 1. Rcl1 structure and domain organization.

Fig 1. Rcl1 structure and domain organization.
  • Tanaka N, Smith P, Shuman S

  • RNA. 2011 Apr;17(4):595-602.

2011-04-28

Fig A2. Results in rats xenografted with human neuroblastoma. Treatment with 3F8 (160 mg/m2, or 4.8 mg/kg) produced tumor shrinkage with or without prior administration of heat-modified 3F8 (HM3F8; 40 mg/m2, or 1.2 mg/kg; a heated-to-native ratio of 1:4).

Fig A2. Results in rats xenografted with human neuroblastoma. Treatment with 3F8 (160 mg/m2, or 4.8 mg/kg) produced tumor shrinkage with or without prior administration of heat-modified 3F8 (HM3F8; 40 mg/m2, or 1.2 mg/kg; a heated-to-native ratio of 1:4).
  • Kushner BH, Kramer K, Modak S, Cheung NK

  • J Clin Oncol. 2011 Mar 20;29(9):1168-74.

2011-04-27

Fig 4a. RAD51AP1 colocalizes with DMC1 foci on meiotic chromatin.

Fig 4a. RAD51AP1 colocalizes with DMC1 foci on meiotic chromatin.
  • Dray E, Dunlop MH, Kauppi L, Filippo JS, Wiese C, Tsai MS, Begovic S, Schild D, Jasin M, Keeney S, Sung P

  • Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3560-5.

2011-04-26

Graphical abstract. Regulation of IL-2 availability and resultant signaling through CD25 by Treg cells was found to play an important role.

Graphical abstract. Regulation of IL-2 availability and resultant signaling through CD25 by Treg cells was found to play an important role.
  • Chen Y, Haines CJ, Gutcher I, Hochweller K, Blumenschein WM, McClanahan T, Hämmerling G, Li MO, Cua DJ, McGeachy MJ

  • Immunity. 2011 Mar 25;34(3):409-21.

2011-04-25

Fig 5. (A) In unperturbed conditions HER2-dependent activation of AKT inhibits the cyclin E/CDK2 inhibitor p27. (B) Inhibition of HER2 suppresses AKT activity leading to increased levels of p27 and inhibition of the cyclin E/Cdk2 activity. (C) Trastuzumab-resistant cells harboring an amplification of cyclin E renders these cells insensitive to the negative regulation by p27.

Fig 5. (A) In unperturbed conditions HER2-dependent activation of AKT inhibits the cyclin E/CDK2 inhibitor p27. (B) Inhibition of HER2 suppresses AKT activity leading to increased levels of p27 and inhibition of the cyclin E/Cdk2 activity. (C) Trastuzumab-resistant cells harboring an amplification of cyclin E renders these cells insensitive to the negative regulation by p27.
  • Scaltriti M, Eichhorn PJ, Cortés J, Prudkin L, Aura C, Jiménez J, Chandarlapaty S, Serra V, Prat A, Ibrahim YH, Guzmán M, Gili M, Rodríguez O, Rodríguez S, Pérez J, Green SR, Mai S, Rosen N, Hudis C, Baselga J

  • Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3761-6.

2011-04-21

Conclusions. We found no evidence to support the recommendation that men with high PSA velocity should be biopsied in the absence of other indications; this measure should not be included in practice guidelines.

Conclusions. We found no evidence to support the recommendation that men with high PSA velocity should be biopsied in the absence of other indications; this measure should not be included in practice guidelines.
  • Vickers AJ, Till C, Tangen CM, Lilja H, Thompson IM

  • J Natl Cancer Inst. 2011 Mar 16;103(6):462-9.

2011-04-20

Fig 1. Replication of the association between PSA at ages 44-50 and prostate cancer is shown.

Fig 1. Replication of the association between PSA at ages 44-50 and prostate cancer is shown.
  • Lilja H, Cronin AM, Dahlin A, Manjer J, Nilsson PM, Eastham JA, Bjartell AS, Scardino PT, Ulmert D, Vickers AJ

  • Cancer. 2011 Mar 15;117(6):1210-9.

2011-04-19

Fig 1.Aggregation and methionine oxidation of hEPO (43–77). (A) The sequences of the synthetic hEPO (43–77) fragments. (B) Methionine oxidation.

Fig 1.Aggregation and methionine oxidation of hEPO (43–77). (A) The sequences of the synthetic hEPO (43–77) fragments. (B) Methionine oxidation.
  • Tan Z, Shang S, Danishefsky SJ

  • Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4297-302.

2011-04-18

Fig 1a. Examination of opioid peptide and synaptic protein immunoreactivity (-ir) in the hippocampal formation.

Fig 1a. Examination of opioid peptide and synaptic protein immunoreactivity (-ir) in the hippocampal formation.
  • Williams TJ, Mitterling KL, Thompson LI, Torres-Reveron A, Waters EM, McEwen BS, Gore AC, Milner TA

  • Brain Res. 2011 Mar 16;1379:71-85.

2011-04-15

Fig 1B. Preoperative and postoperative eGFR in patients with PN (blue circles) and conversion from PN to RN (red circles).

Fig 1B. Preoperative and postoperative eGFR in patients with PN (blue circles) and conversion from PN to RN (red circles).
  • Galvin DJ, Savage CJ, Adamy A, Kaag M, O'Brien MF, Kallingal G, Russo P

  • J Urol. 2011 Apr;185(4):1204-9.

2011-04-14

Fig 1. Model of glioblastoma cells transdifferentiating into endothelial cells.

Fig 1. Model of glioblastoma cells transdifferentiating into endothelial cells.
  • Hormigo A, Ding BS, Rafii S

  • Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4271-2.

2011-04-13

Fig 2a. Conserved active site of plant and bacterial Hen1 methyltransferase domains.

Fig 2a. Conserved active site of plant and bacterial Hen1 methyltransferase domains.
  • Jain R, Shuman S

  • RNA. 2011 Mar;17(3):429-38.

2011-04-12

Fig 1. The injection of a tumor associated antigen (TAA) binding antibody (Ab1) leads to an immune response containing antibodies (Ab2) mimicking the structure of the original antigen.

Fig 1. The injection of a tumor associated antigen (TAA) binding antibody (Ab1) leads to an immune response containing antibodies (Ab2) mimicking the structure of the original antigen.
  • Pfisterer J, Harter P, Simonelli C, Peters M, Berek J, Sabbatini P, du Bois A

  • Expert Opin Biol Ther. 2011 Mar;11(3):395-403.

2011-04-11

Fig 1. Schematic representation of the emergence and lineage contribution of the first three cell lineages of the mammalian embryo.

Fig 1. Schematic representation of the emergence and lineage contribution of the first three cell lineages of the mammalian embryo.
  • Artus J, Hadjantonakis AK

  • Methods Mol Biol. 2011;693:37-56.

2011-04-08

Fig 5. CT imaging of a lymph node of a mouse with bismuth nanoparticles.

Fig 5. CT imaging of a lymph node of a mouse with bismuth nanoparticles.
  • Grimm J, Scheinberg DA

  • Semin Radiat Oncol. 2011 Apr;21(2):80-7.

2011-04-07

Figure 2. Gross and microscopic appearance of acute/subacute renal IRE.

Figure 2. Gross and microscopic appearance of acute/subacute renal IRE.
  • Deodhar A, Monette S, Single GW Jr, Hamilton WC Jr, Thornton R, Maybody M, Coleman JA, Solomon SB

  • Urology. 2011 Mar;77(3):754-60.

2011-04-06

Fig 2. MYC cooperates with PI3K-pathway signaling in bigenic PTENpc-/- /Hi-MYC mice resulting in invasive adenocarcinoma after 3 months.

Fig 2. MYC cooperates with PI3K-pathway signaling in bigenic PTENpc-/- /Hi-MYC mice resulting in invasive adenocarcinoma after 3 months.
  • Clegg NJ, Couto SS, Wongvipat J, Hieronymus H, Carver BS, Taylor BS, Ellwood-Yen K, Gerald WL, Sander C, Sawyers CL

  • PLoS One. 2011 Mar 4;6(3):e17449.
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2011-04-05

Fig 4. SIRT3 Regulates HIF1α Stability through ROS

Fig 4. SIRT3 Regulates HIF1α Stability through ROS
  • Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, Haigis MC

  • Cancer Cell. 2011 Mar 8;19(3):416-28.

2011-04-04

Fig 6. Actuarial local control (Kaplan-Meir method) of bone lesions as a function of dose. Y axis represents local relapse-free survival (%).

Fig 6. Actuarial local control (Kaplan-Meir method) of bone lesions as a function of dose. Y axis represents local relapse-free survival (%).
  • Greco C, Zelefsky MJ, Lovelock M, Fuks Z, Hunt M, Rosenzweig K, Zatcky J, Kim B, Yamada Y

  • Int J Radiat Oncol Biol Phys. 2011 Mar 15;79(4):1151-7.

2011-04-01

Fig 1a. Late PAR pairing during male meiosis.

Fig 1a. Late PAR pairing during male meiosis.
  • Kauppi L, Barchi M, Baudat F, Romanienko PJ, Keeney S, Jasin M

  • Science. 2011 Feb 18;331(6019):916-20.