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Fig 8. Schematic representation of the pathway described in the study.
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Fig 3b. Adipose tissue response to leptin treatment and withdrawal.
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Fig 1. Domain organization of M. smegmatis UvrD2.
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Fig 1. Orthogonal film based implant evaluation. Surgical clips identified for cavity delineation and dummy sources were placed in catheters for subsequent position digitization.
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Fig. 3b. Covariation of CD8 and SHP-1 levels limits the frequencies of hypo- and hyperresponsive cells. Computer model for T cell activation demonstrate how the EC50 for ppERK responsiveness is determined by both CD8 and SHP-1 levels.
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Fig 1d. Fusion protein expression in transiently tranfected Cos7 cells and stably transfected R3327-CD/mDsRed or R3327-CD/UPRT/mDsRed cells
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Fig 8a. siRNA-mediated depletion of hChlR1, Fen1, or Scc1 leads to defects in sister chromatid pairing.
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Fig 2. Structural homology between Clp1 and T4 Pnk.
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Fig. 1. Transformation with plasmids carrying wild type (wt) human CHEK2, as well as the Y424H variant, represses the normally reduced viability due to Rad53 deletion in the Rad53-null sml1-null yeast S. cerevisiae.
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Fig 2. Histologic examination of the tumor revealed discrete lobules of angiomatous tissue with inflammatory cells to the level of the muscular layer of the lower lip.
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Fig 1c. Immunocytochemistry for skeletal myosin heavy chain (MyHC) expression.
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Fig 1c. Skin retracted with a long-stat retractor to avoid skin necrosis secondary to high-dose irradiation.
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Fig 1a. Structural alignment of the BRCT-related region in the T-ag helicase domain with the C-terminal BRCT repeat in 53BP1.
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Fig. 1b. Schematic representation of how to submit trachelectomy margin at the time of frozen-section analysis. Trachelectomy opened after shave showing grossly visible tumor; distance to margin is measured grossly.
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Fig. 4c. Assessment of LLC Tumor Volume, Microvessel Density, Necrosis, and Long-Term Tumor Growth in Mice Treated with Paclitaxel or Gemcitabine in Combination with DC101C57BL/6 mice bearing 500 mm3 LLC tumors were treated with paclitaxel (PTX) or gemcitabine (GEM) with or without DC101 administered 24 hr prior to the chemotherapy drug.
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Fig 4. Photograph and {gamma}-camera image of 4-quadrant bar phantom, Energy spectrum for 662-keV {gamma}-ray emitted by 137Cs.
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Fig 7c. Direct intratumoral injection of si-SV1 induces apoptosis and reduces tumor growth in vivo.
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Fig 8. Confirmation of novel gains on chromosomes 7q22 and 1q21.2 using fluorescence in situ hybridization (FISH).
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Fig. 1. Histologic appearance of pediatric GIST.
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Fig. 6c COX-2 expression is upregulated in the SCDH of NR1 KO (Cre) mice.
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Fig. 6E 2-year-old boy who presented with hoarseness and difficulty swallowing.
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Fig. 2b. OP conjugation to TFO/LNA restricts OP cleavage activity to a limited number of genomic sites. Colocalization of phosphoH2AX and 53BP1foci, 24 h after OP-19-mer TFO/LNA transfection.
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Fig. 4 A Three-Cell Model for TGF-β1-Dependent Regulation of T Cells
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Fig. 5e Stabilization of p27
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Fig. 1 Crystal structure of the globular head region of NiV-G.
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Fig. 1 Representative photograph of pancreatic cancer cells demonstrating eGFP expression after vMyxgfp infection with MOI 10.
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Fig. 2h. Detection of apoptotic NY-ESO-1-expressing melanoma cells after CHP-NY-ESO-1 vaccination. Double-labeling of tumor cells undergoing apoptosis is shown by localized, yellow fluorescence (g, h). A significant increase in apoptotic melanoma cells was observed after the third vaccination with CHP-NY-ESO-1 (on day 31).
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Fig. 5d. Top1cc's induce Brca1-dependent degradation of Top1 without substantial degradation of Pol II. MEF cells of the indicated genotype were treated with 25 µM CPT for the indicated times. Western blotting analyses of Top1 and Pol II. Pol IIa (hypophosphorylated CTD) and Pol IIo (hyperphosphorylated CTD) forms are indicated. Tubulin was used as a loading control. The top panel shows quantification of Top1 expression shown.
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Fig 1d. Adenocarcinoma, histology. Mucinous BAC. The alveolar walls are slightly thickened by fibrosis and chronic inflammation and they are lined by tall columnar cells with basally oriented nuclei and abundant mucin-filled apical cytoplasm (case showed KRAS mutation).
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Fig 1. Structural insights to TopIB transesterification chemistry.
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Fig 18b. Muscle lymphoma on ultrasound. On power Doppler image, the mass is hypervascular.
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Fig 3. 60-year-old woman with diffuse disease and calcifications in left anterior descending coronary artery (LAD) (arrow) extending into left circumflex artery.
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Fig 2. Quantitative analysis by BLI of adoptively transferred T-cell persistence and tumor progression in individual animals.
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Fig 11. Leptomeningeal PCNSL.
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Fig 2. All biopsy specimens demonstrated similar changes: mild acanthosis, no hyperkeratosis, basilar hyperpigmentation, and scattered melanophages in papillary dermis.
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Fig 3a. 18F-FDG PET images of pelvis show intense 18F-FDG uptake within known cervical tumor at site of cervical mass seen on CT.
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Fig 6b. Silvestrol synergizes with doxorubicin to induce apoptosis in
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Fig 4c. Small cell lung cancer of the left pulmonary hilum with an adjacent satellite lung nodule.
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Fig 2a. Significant linkage disequilibrium in the region at 6q22.33 associating with breast cancer in AJs.
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Fig 5b. Telomere dysfunction in bone marrow of POT1b+/ñmTRñ/ñ mice.
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Fig. 5D The percentage of tumor-bearing animals with a specific tumor type is plotted for the indicated genotype.
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Fig 6. Nectin-1 and E-cadherin IHC, and hematoxylin and eosin (H and E) staining of HNSCC.
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Fig 4. Sequence and Structural Features of Mammalian and Invertebrate Mirtrons.
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Fig 3b. Isodose display for the brain-sparing radiotherapy technique.
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Fig 10e. FDG PET/CT performed on a 50 year old woman with newly diagnosed invasive ductal carcinoma of the right breast with palpable right axillary nodes.
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Fig 1c. Bone marrow samples of CML patients in chronic phase (n = 81) were stained with anti-PML antibody (brown) and anti-CD34 (red). Insets show PML-staining in blasts (B) and differentiated neutrophils (N).
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Fig 7. Models of MCP-1 and MCP-3 functions in monocyte recruitment process. A, Parallel model. B, Series model.
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Fig 4a. MVD is disrupted during CL regression. MVD was assessed by staining with CD31 antibody.
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Fig 1. Penetrating light is multiply backscattered light; superficial light is singly backscattered light; surface glare is specular reflectance.
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Fig 4. CD133 is expressed in differentiated epithelium of normal human colon.
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Fig 1b. Promyelocytic leukemia zinc-finger gene (PLZF) is phosphorylated in vivo and in vitro by cyclin-dependent kinase-2 (CDK2).
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Fig 8. Differential expression of b2-AR in human prostate specimens.
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Fig 2a. Infection of sciatic nerves with wild-type HSV and NV1023.
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Fig 6d. A schematic model of brown fat determination by PRDM16.
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Fig. 1 The figure shows the typical radiographic appearance of low-grade juxtacortical osteogenic sarcoma demonstrating a lobulated ossific mass on the surface of the bone.
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Fig 2. Each nucleotide triplet is bound by three consecutive RecA protomers.
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Fig. 5. Coronal representation of a patient with thymic carcinoma treated with sequential tomotherapy IMRT.
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Fig 5. Dcr-2- and AGO2-Deficient Cells Exhibit Increased Levels of TE Transcripts. Relative RNA levels (mean ± SD) are shown.(A) TE transcripts were measured by quantitative RT-PCR of S2 cells treated with dsRNA against Dcr-2 or AGO2, normalized to GFP dsRNA-treated cells.
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Fig 2a. In non-neoplastic renal tissue adjacent to tumor, PSMA was exclusively expressed in the epithelial cells of the proximal tubules and absent in native renal vessels, glomeruli and stroma.
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Fig 1. Preoperative CT scan of the case patient.
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Fig 2a. Results of 2880 Compound Library Screen. Scale bar corresponds to 80 micrometer.
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