Return to Today's science sparks archives

2007-01-02

Figure 5. Nonmelanocytic lesions with homogenous bluish pigmentation

Figure 5. Nonmelanocytic lesions with homogenous bluish pigmentation
  • Scope A, Benvenuto-Andrade C, Agero AL, Marghoob AA

  • Dermatol Surg. 2006 Nov;32(11):1398-406.

2007-01-03

Figure 1. Role of BH4 in modulating pain systems.

Figure 1. Role of BH4 in modulating pain systems.
  • Pasternak GW, Inturrisi CE

  • Nat Med. 2006 Nov;12(11):1243-4.

2007-01-04

PCNA and phospho-histone H3 positive germ cells were present in the abnormal cell masses found in the lumen of the seminiferous tubules.

PCNA and phospho-histone H3 positive germ cells were present in the abnormal cell masses found in the lumen of the seminiferous tubules.
  • Refik-Rogers J, Manova K, Koff A

  • Cell Cycle. 2006 Sep;5(17):1966-73.

2007-01-05

PI3K/AKT/mTOR pathway showing the mTOR protein complexes, mTOR/RAPTOR and mTOR/RICTOR, and the feedback loop involving IGF-IR.

PI3K/AKT/mTOR pathway showing the mTOR protein complexes, mTOR/RAPTOR and mTOR/RICTOR, and the feedback loop involving IGF-IR.
  • Duran I, <em>Kortmansky J</em>, Singh D, et al

  • Br J Cancer. 2006 Nov 6;95(9):1148-54.

2007-01-08

Fig. 1. Generation and infection of MMTV-tva transgenic mice.

Fig. 1. Generation and infection of MMTV-tva transgenic mice.
  • Du Z, Podsypanina K, Huang S, McGrath A, Toneff MJ, Bogoslovskaia E, Zhang X, Moraes RC, Fluck M, Allred DC, Lewis MT, Varmus HE, Li Y

  • Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17396-401.

2007-01-09

FIG 8. Numerous small vacuoles partially obscuring the MTSC architecture and mimicking clear cells.

FIG 8. Numerous small vacuoles partially obscuring the MTSC architecture and mimicking clear cells.
  • Fine SW, Argani P, DeMarzo AM, Delahunt B, Sebo TJ, Reuter VE, Epstein JI

  • Am J Surg Pathol. 2006 Dec;30(12):1554-60.

2007-01-10

Figure 1. CMV 2b causes developmental anomalies in Arabidopsis.

Figure 1. CMV 2b causes developmental anomalies in Arabidopsis.
  • Zhang X, Yuan YR, Pei Y, Lin SS, Tuschl T, Patel DJ, Chua NH

  • Genes Dev. 2006 Dec 1;20(23):3255-68.

2007-01-11

Figure 2. A, HER-2/neu mammary tumor in Id1+/+ mouse stained for Id1 using anti-Id1 antibody 37-2...

Figure 2. A, HER-2/neu mammary tumor in Id1+/+ mouse stained for Id1 using anti-Id1 antibody 37-2...
  • Perk J, Gil-Bazo I, Chin Y, de Candia P, Chen JJ, Zhao Y, Chao S, Cheong W, Ke Y, Al-Ahmadie H, Gerald WL, Brogi E, Benezra R

  • Cancer Res. 2006 Nov 15;66(22):10870-7.

2007-01-12

Fig 6. Distribution of the tau/LacZ and tau/GFP fusion proteins in the transgenic mouse spinal cord.

Fig 6. Distribution of the tau/LacZ and tau/GFP fusion proteins in the transgenic mouse spinal cord.
  • Xu J, Xu M, Pan YX

  • BMC Mol Biol. 2006 Nov 13;7:41.

2007-01-15

Fig 1. Recombination-dependent replication and direct-restart mechanisms of reactivating forks that have been stalled by leading-strand-specific lesions.

Fig 1. Recombination-dependent replication and direct-restart mechanisms of reactivating forks that have been stalled by leading-strand-specific lesions.
  • Heller RC, Marians KJ

  • Nat Rev Mol Cell Biol. 2006 Dec;7(12):932-43.

2007-01-16

Fig 1. Diagnostic cen/tel FISH patterns in mouse spermatocytes.

Fig 1. Diagnostic cen/tel FISH patterns in mouse spermatocytes.
  • Liebe B, Petukhova G, Barchi M, et al.

  • Exp Cell Res. 2006 Nov 15;312(19):3768-81.

2007-01-17

Figure 4. Patterns of Metastatic Colonization

Figure 4. Patterns of Metastatic Colonization
  • Gupta GP, Massague J

  • Cell. 2006 Nov 17;127(4):679-95.

2007-01-18

Fig 2. Histopathology of lesion in figure 1 showing the features of a seborrheic keratosis.

Fig 2. Histopathology of lesion in figure 1 showing the features of a seborrheic keratosis.
  • Kopf AW, Rabinovitz H, Marghoob A, Braun RP, Wang S, Oliviero M, Polsky D

  • J Am Acad Dermatol. 2006 Dec;55(6):1089-91.

2007-01-19

Fig 4. The Nuclear Structures Formed by PMLWT or Its Mutants Do Not Overlap with Splicing Speckles...

Fig 4. The Nuclear Structures Formed by PMLWT or Its Mutants Do Not Overlap with Splicing Speckles...
  • Shen TH, Lin HK, Scaglioni PP, Yung TM, Pandolfi PP

  • Mol Cell. 2006 Nov 3;24(3):331-9.

2007-01-22

Fig 3C. 67-year-old woman with cholangiocarcinoma.

Fig 3C. 67-year-old woman with cholangiocarcinoma.
  • Zhang J, Israel GM, Hecht EM, Krinsky GA, Babb JS, Lee VS

  • AJR Am J Roentgenol. 2006 Dec;187(6):1564-70.

2007-01-23

Fig 8. A permanent cerclage with #0 Ethibond is placed and the knot tied posteriorly.

Fig 8. A permanent cerclage with #0 Ethibond is placed and the knot tied posteriorly.
  • Abu-Rustum NR, Sonoda Y, Black D, Levine DA, Chi DS, Barakat RR

  • Gynecol Oncol. 2006 Dec;103(3):807-13

2007-01-24

Fig 7. Line demonstrates method of measurement of vocal fold diameter.

Fig 7. Line demonstrates method of measurement of vocal fold diameter.
  • Krishna P, Rosen CA, Branski RC, Wells A, Hebda PA

  • Otolaryngol Head Neck Surg. 2006 Dec;135(6):937-45.

2007-01-25

Fig. 2. Case 2. Admixture of foamy cells with more typical-appearing cords of inverted papilloma.

Fig. 2. Case 2. Admixture of foamy cells with more typical-appearing cords of inverted papilloma.
  • Fine SW, Epstein JI

  • Hum Pathol. 2006 Dec;37(12):1577-82.

2007-01-29

Ligand binding to the EGFR causes receptor dimerization...

Ligand binding to the EGFR causes receptor dimerization...
  • Saltz L, Easley C, Kirkpatrick P

  • Nat Rev Drug Discov. 2006 Dec;5(12):987-8.

2007-01-30

Figure 1. Stem-like cells in brain tumors.

Figure 1. Stem-like cells in brain tumors.
  • Hambardzumyan D, Squatrito M, Holland EC

  • Cancer Cell. 2006 Dec;10(6):454-6.

2007-01-31

Fig 1. Epidural compression.

Fig 1. Epidural compression.
  • Bilsky M, Smith M

  • Hematol Oncol Clin North Am. 2006 Dec;20(6):1307-17.

2007-02-01

Fig 6. Proposed model for the role of PML in regulating IFN-&gamma; signaling.

Fig 6. Proposed model for the role of PML in regulating IFN-&gamma; signaling.
  • Choi YH, Bernardi R, Pandolfi PP, Benveniste EN

  • Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18715-20.

2007-02-02

Fig. 2. (B) Schematic representation of structure of catalytic site of histone deacetylase protein with SAHA.

Fig. 2. (B) Schematic representation of structure of catalytic site of histone deacetylase protein with SAHA.
  • Marks PA

  • Semin Cancer Biol. 2006 Dec;16(6):436-43.

2007-02-05

Figure 4. Conservation of the Exosome Surface

Figure 4. Conservation of the Exosome Surface
  • Liu Q, Greimann JC, Lima CD

  • Cell. 2006 Dec 15;127(6):1223-37.

2007-02-06

Fig 1. Overall survival estimate by body mass index (BMI) group.

Fig 1. Overall survival estimate by body mass index (BMI) group.
  • von Gruenigen VE, Tian C, Frasure H, Waggoner S, Keys H, Barakat RR

  • Cancer. 2006 Dec 15;107(12):2786-91.

2007-02-07

Fig 4. Assay for &beta;-galactosidase activity.

Fig 4. Assay for &beta;-galactosidase activity.
  • Shih AH, Holland EC

  • Neoplasia. 2006 Dec;8(12):1072-82.

2007-02-08

Fig 3. Immunocytology of full-length RER.

Fig 3. Immunocytology of full-length RER.
  • Schefe JH, Menk M, Reinemund J, Effertz K, Hobbs RM, Pandolfi PP, Ruiz P, Unger T, Funke-Kaiser H

  • Circ Res. 2006 Dec 8;99(12):1355-66.

2007-02-09

Fig 1. A coronal maximum intensity projection image obtained from excretory phase CT urography (CTU) shows bilateral urinary collecting systems and bladder are opacified with contrast.

Fig 1. A coronal maximum intensity projection image obtained from excretory phase CT urography (CTU) shows bilateral urinary collecting systems and bladder are opacified with contrast.
  • Zhang J, Gerst S, Lefkowitz RA, Bach A

  • Radiol Clin North Am. 2007 Jan;45(1):183-205.

2007-02-12

Fig. 1. Aurora-A activation.

Fig. 1. Aurora-A activation.
  • Carvajal RD, Tse A, Schwartz GK

  • Clin Cancer Res. 2006 Dec 1;12(23):6869-75.

2007-02-13

FIG 1. Left partial hepatectomy resection for a large (17 cm), solitary, cystic, and hemorrhagic mass in a 50-year-old woman (case 7).

FIG 1. Left partial hepatectomy resection for a large (17 cm), solitary, cystic, and hemorrhagic mass in a 50-year-old woman (case 7).
  • Agaram NP, Baren A, Antonescu CR

  • Ultrastruct Pathol. 2006 Nov-Dec;30(6):403-8.

2007-02-14

FIG 1. (B-E) E18.5 Limb skeletal preparations highlight the abnormalities in

FIG 1. (B-E) E18.5 Limb skeletal preparations highlight the abnormalities in
  • Weatherbee SD, Anderson KV, Niswander LA

  • Development. 2006 Dec;133(24):4993-5000.

2007-02-15

FIG 5. Interactions of covalent bound topoisomerase with the 5'-CCCTT/3'-GGGAA site.

FIG 5. Interactions of covalent bound topoisomerase with the 5'-CCCTT/3'-GGGAA site.
  • Yakovleva L, Lai J, Kool ET, Shuman S

  • J Biol Chem. 2006 Nov 24;281(47):35914-21.

2007-02-16

Fig. 1. Putative paracrine and autocrine effects of VEGF and PDGF within RCC and targets of clinically effective pharmacologic agents.

Fig. 1. Putative paracrine and autocrine effects of VEGF and PDGF within RCC and targets of clinically effective pharmacologic agents.
  • Patel PH, Chadalavada RS, Chaganti RS, Motzer RJ

  • Clin Cancer Res. 2006 Dec 15;12(24):7215-20.

2007-02-19

FIG 7. Schematic summary of the Smad phosphorylations targeted by the phosphatase activity of SCPs and other Smad phosphatases.

FIG 7. Schematic summary of the Smad phosphorylations targeted by the phosphatase activity of SCPs and other Smad phosphatases.
  • Sapkota G, Knockaert M, Alarcon C, Montalvo E, Brivanlou AH, Massague J

  • J Biol Chem. 2006 Dec 29;281(52):40412-9.

2007-02-20

Fig 2. IMDA reactions of allenic and olefinic intermediates.

Fig 2. IMDA reactions of allenic and olefinic intermediates.
  • Cook SP, Danishefsky SJ

  • Org Lett. 2006 Dec 7;8(25):5693-5.

2007-02-21

Fig 5. Leptomeningeal lymphoma.

Fig 5. Leptomeningeal lymphoma.
  • J¸rgen Rademaker

  • Radiol Clin North Am. 2007 Jan; 45(1):69-83.

2007-02-22

Fig 1. (e) Simulated annealing omit map contoured at 1.2 &sigma;, covering the isopeptide bond and selected active site residues in the SENP2ñRanGAP1ñSUMO-1 structure.

Fig 1. (e) Simulated annealing omit map contoured at 1.2 &sigma;, covering the isopeptide bond and selected active site residues in the SENP2ñRanGAP1ñSUMO-1 structure.
  • Reverter D, Lima CD

  • Nat Struct Mol Biol. 2006 Dec;13(12):1060-8.

2007-02-23

Fig 1. Schematic representation of the bacterial artificial chromosome (BAC) retrofitting protocol.

Fig 1. Schematic representation of the bacterial artificial chromosome (BAC) retrofitting protocol.
  • Tomishima MJ, Hadjantonakis AK, Gong S, Studer L

  • Stem Cells. 2007 Jan;25(1):39-45.

2007-02-26

Fig 19. A 54-year-old woman with adenocarcinoma of the right lung. (B) Note musculoskeletal metastases in the legs.

Fig 19. A 54-year-old woman with adenocarcinoma of the right lung. (B) Note musculoskeletal metastases in the legs.
  • Ginsberg MS, Grewal RK, Heelan RT

  • Radiol Clin North Am. 2007 Jan;45(1):21-43.

2007-02-27

Fig 3. Memory impairment in mice injected with serum containing anti-NMDAR Abs and given LPS...

Fig 3. Memory impairment in mice injected with serum containing anti-NMDAR Abs and given LPS...
  • Kowal C, Degiorgio LA, Lee JY, Edgar MA, Huerta PT, Volpe BT, Diamond B

  • Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19854-9.

2007-02-28

Fig 2B. 20-year-old man with familial adenomatous polyposis and innumerable small colon polyps.

Fig 2B. 20-year-old man with familial adenomatous polyposis and innumerable small colon polyps.
  • Gollub MJ, Akhurst T, Markowitz AJ, Weiser MR, Guillem JG, Smith LM, Larson SM, Margulis AR

  • AJR Am J Roentgenol. 2007 Jan; 188(1):130-8.

2007-03-01

Fig 3C. Examples of aberrant mitosis of Mad1+/ñ, Mad2+/ñ, and Mad1+/ñMad2+/ñ MEFs in prometaphase, metaphase, anaphase, and telophase. Antiñ&alpha;-tubulin (green) staining and DNA staining with DAPI (red) were done.

Fig 3C. Examples of aberrant mitosis of Mad1+/ñ, Mad2+/ñ, and Mad1+/ñMad2+/ñ MEFs in prometaphase, metaphase, anaphase, and telophase. Antiñ&alpha;-tubulin (green) staining and DNA staining with DAPI (red) were done.
  • Iwanaga Y, Chi YH, Miyazato A, Sheleg S, Haller K, Peloponese JM Jr, Li Y, Ward JM, Benezra R, Jeang KT

  • Cancer Res. 2007 Jan 1;67(1):160-6.

2007-03-02

Fig 8. Schematic representation of the proposed mechanism of action for C-terminus of Mdm2.

Fig 8. Schematic representation of the proposed mechanism of action for C-terminus of Mdm2.
  • Poyurovsky MV, Priest C, Kentsis A, Borden KL, Pan ZQ, Pavletich N, Prives C

  • EMBO J. 2007 Jan 10;26(1):90-101.

2007-03-05

Fig 1. Potential mechanisms through which cathepsins promote tumor invasion.

Fig 1. Potential mechanisms through which cathepsins promote tumor invasion.
  • Gocheva V, Joyce JA

  • Cell Cycle. 2007 Jan;6(1):60-4.

2007-03-06

Fig 1. The different steps involved in object-oriented image analysis.

Fig 1. The different steps involved in object-oriented image analysis.
  • Saidi O, Cordon-Cardo C, Costa J

  • Nat Clin Pract Urol. 2007 Jan;4(1):39-45.

2007-03-07

Fig 16.  Themaxillary branch of the trigeminal nerve innervates the mucosa of the hard palateand upper alveolus.

Fig 16. Themaxillary branch of the trigeminal nerve innervates the mucosa of the hard palateand upper alveolus.
  • Stambuk HE, Karimi S, Lee N, Patel SG

  • Radiol Clin North Am. 2007 Jan;45(1):1-20.

2007-03-08

Fig 2D. 63-year-old man with clinical stage T1c prostate carcinoma with Gleason score of 4 + 4, prostate-specific antigen level of 12.9 ng/mL.

Fig 2D. 63-year-old man with clinical stage T1c prostate carcinoma with Gleason score of 4 + 4, prostate-specific antigen level of 12.9 ng/mL.
  • Wang L, Zhang J, Schwartz LH, Eisenberg H, Ishill NM, Moskowitz CS, Scardino P, Hricak H

  • AJR Am J Roentgenol. 2007 Jan;188(1):99-104.

2007-03-09

Fig 1. Structure of SAHA (vorinostat) bound to an HDAC-like protein (adapted from ref. 32, Fig. 3).

Fig 1. Structure of SAHA (vorinostat) bound to an HDAC-like protein (adapted from ref. 32, Fig. 3).
  • Marks PA, Breslow R

  • Nat Biotechnol. 2007 Jan;25(1):84-90.

2007-03-12

Fig 1. Assessment of Response to Antiangiogenic Therapy with AZD2171 by Utilizing MRI and Biomarkers.

Fig 1. Assessment of Response to Antiangiogenic Therapy with AZD2171 by Utilizing MRI and Biomarkers.
  • Hormigo A, Gutin PH, Rafii S

  • Cancer Cell. 2007 Jan;11(1):6-8.

2007-03-13

Fig 1. Spontaneous Chromosomal Instability in Pten Null MEFs.

Fig 1. Spontaneous Chromosomal Instability in Pten Null MEFs.
  • Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y

  • Cell. 2007 Jan 12;128(1):157-70.

2007-03-14

Fig 4B. In vitro stem/progenitor cell differentiation depends on the cell intrinsic expression of Id1.

Fig 4B. In vitro stem/progenitor cell differentiation depends on the cell intrinsic expression of Id1.
  • Jankovic V, Ciarrocchi A, Boccuni P, DeBlasio T, Benezra R, Nimer SD

  • Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1260-5.

2007-03-15

Fig 1. Four Gene-Expression Signatures.

Fig 1. Four Gene-Expression Signatures.
  • Massagu&eacute;, Joan

  • N Engl J Med. 2007 Jan 18;356(3):294-7.

2007-03-16

Fig 4E. Tumor Susceptibility in TetO-Mad2/CMV-tTA Mice...and a dysplasia of the fallopian tubes.

Fig 4E. Tumor Susceptibility in TetO-Mad2/CMV-tTA Mice...and a dysplasia of the fallopian tubes.
  • Sotillo R, Hernando E, D&iacute;az-Rodr&iacute;guez E, Teruya-Feldstein J, Cord&oacute;n-Cardo C, Lowe SW, Benezra R

  • Cancer Cell. 2007 Jan;11(1):9-23.

2007-03-19

Fig 6. The uterosacral ligament can be divided.

Fig 6. The uterosacral ligament can be divided.
  • Sonoda Y, Abu-Rustum NR

  • Gynecol Oncol. 2007 Feb;104(2 Suppl):50-5.

2007-03-20

Fig 5. Changes in morphology and EGFP fluorescence of pEGFP-C85 cells exposed for 48 h to 1 &micro;M methotrexate.

Fig 5. Changes in morphology and EGFP fluorescence of pEGFP-C85 cells exposed for 48 h to 1 &micro;M methotrexate.
  • Dabrowska M, Hendrikx PJ, Skierski J, Malinowska M, Bertino JR, Rode W

  • Eur J Pharmacol. 2007 Jan 26;555(2-3):93-9.

2007-03-21

Switching class.

Switching class.
  • Chaudhuri J, Jasin M

  • Science. 2007 Jan 19;315(5810):335-6.

2007-03-22

Fig 1G. Squamous cell carcinoma cases with strong desmoglein 3 staining.

Fig 1G. Squamous cell carcinoma cases with strong desmoglein 3 staining.
  • Fukuoka J, Dracheva T, Shih JH, Hewitt SM, Fujii T, Kishor A, Mann F, Shilo K, Franks TJ, Travis WD, Jen J

  • Hum Pathol. 2007 Feb;38(2):276-83.

2007-03-23

Fig 6A. Neural phenotype in embryos injected at eight-cell stage into both dorsal-animal blastomeres with 30 ng of Smurf1-MO.

Fig 6A. Neural phenotype in embryos injected at eight-cell stage into both dorsal-animal blastomeres with 30 ng of Smurf1-MO.
  • Sapkota G, Alarcon C, Spagnoli FM, Brivanlou AH, Massague J

  • Mol Cell. 2007 Feb 9;25(3):441-54.

2007-03-26

Fig. 6. Parasagittal view of whole mount section of PBN shows smooth muscle fibers in continuation with detrusor muscle...

Fig. 6. Parasagittal view of whole mount section of PBN shows smooth muscle fibers in continuation with detrusor muscle...
  • Secin FP, Karanikolas N, Gopalan A, Bianco FJ, Shayegan B, Touijer K, Olgac S, Myers RP, Dalbagni G, Guillonneau B

  • J Urol. 2007 Feb;177(2):521-5.

2007-03-27

Fig 1B. Higher power view of 2+ staining in a biphasic synovial sarcoma.

Fig 1B. Higher power view of 2+ staining in a biphasic synovial sarcoma.
  • Terry J, Saito T, Subramanian S, Ruttan C, Antonescu CR, Goldblum JR, Downs-Kelly E, Corless CL, Rubin BP, van de Rijn M, Ladanyi M, Nielsen TO

  • Am J Surg Pathol. 2007 Feb;31(2):240-6.

2007-03-28

Fig 2. Transaxial, coronal, and sagittal views of clinical (A) and DIBH (B) fused PET and CT images are shown.

Fig 2. Transaxial, coronal, and sagittal views of clinical (A) and DIBH (B) fused PET and CT images are shown.
  • Nehmeh SA, Erdi YE, Meirelles GS, Squire O, Larson SM, Humm JL, Sch&ouml;der H

  • J Nucl Med. 2007 Jan;48(1):22-6.

2007-03-29

Fig 3A. Two-color immunohistological analysis of H2-O expression in GC B cells.

Fig 3A. Two-color immunohistological analysis of H2-O expression in GC B cells.
  • Fallas JL, Yi W, Draghi NA, O'Rourke HM, Denzin LK

  • J Immunol. 2007 Feb 1;178(3):1488-97.

2007-03-30

Fig 1A. Photomicrographs showing extensive deposits of amorphous eosinophilic material consistent with light chain disease.

Fig 1A. Photomicrographs showing extensive deposits of amorphous eosinophilic material consistent with light chain disease.
  • Bhargava P, Rushin JM, Rusnock EJ, Hefter LG, Franks TJ, Sabnis SG, Travis WD

  • Am J Surg Pathol. 2007 Feb;31(2):267-76.