Fig 7. The role of FGFR1-PLAG1 and TGFBR3-PLAG1 in MECA development.

Fig 2. Melanoma brain metastasis response to concurrent SRS and pembrolizumab.

Fig 3. Schematic representation of the EGFR signaling pathway.

Fig 4. CTC phenotypic features, cell subtype classifications, and Shannon index of CTC phenotypic entropy in patient samples.

Fig 5. Demonstration of the extent of mismatch at 8 HLA alleles of CB units selected based on 4 to 6/6 HLA-A, -B antigen, and -DRB1 allele donor–recipient HLA match (n = 377) [37]. The 4 to 6/6 HLA-A, -B antigen, -DRB1 allele donor–recipient match to the patient is shown.

Fig 1. Somatic mutations observed. Heatmap showing the 30 genes most frequently affected by mutations in 98 tumors subjected to targeted massively parallel sequencing from 49 patients with CBC.

Fig 1. ISH analysis of LGR5 expression in normal human small and large intestine.

Fig 2. Ternary crystal structure of cGAS with dsDNA and RU.365.

Fig 2. Benchmarking SplashRNA prediction performance.

Fig 3. Hyperactive MAPK signalling triggers bronchiolar carcinoma by transdifferentiation of club cells.

Fig 1. Kaplan-Meier curves comparing the original and new melanoma-GPA.

Fig 2. Alpha-synuclein oligomers and cytosolic DA amplify each other and synergistically contribute to oxidative stress.

Fig 5. Detection of endolysosomal lipid accumulation in live cells.

Fig 4. Distribution of expected variants vs. incidental pathogenic variants.

Fig 1. Azacitidine Synergizes with Sequential HDACi for Reducing Cell Proliferation.

Fig 7. Differential utilization of GRIP1 phosphorylation at GR-regulated genes.

Fig 6. Ketamine enhances ERK signaling pathway.

Fig 2. Diagnostic algorithm for the evaluation of high-grade (G3) pancreatic neuroendocrine neoplasms. In select cases of high-grade pancreatic neuroendocrine neoplasms, distinguishing between pancreatic neuroendocrine tumours (PanNETs) and pancreatic neuroendocrine carcinomas (PanNECs) can be challenging, but applying an algorithmic approach can facilitate an accurate diagnosis. This approach relies upon integrating associated clinical, imaging and laboratory data, a thorough pathological review of the specimen and prior specimens and immunohistochemical ancillary studies. Adapted from Tang et al.

Graphical Abstract