Fig. 2b. OP conjugation to TFO/LNA restricts OP cleavage activity to a limited number of genomic sites. Colocalization of phosphoH2AX and 53BP1foci, 24 h after OP-19-mer TFO/LNA transfection.

• Triplex-forming oligonucleotide-orthophenanthroline conjugates for efficient targeted genome modification.

Cannata F, Brunet E, Perrouault L, Roig V, Ait-Si-Ali S, Asseline U, Concordet JP, Giovannangeli C


• Proc Natl Acad Sci.
  2008 Jul 15;105(28):9576-81.

Fig. 4 A Three-Cell Model for TGF-β1-Dependent Regulation of T Cells

• TGF-ß: A Master of All T Cell Trades

Li MO, Flavell RA


• Cell.
  2008 Aug 8;134(3):392-404.

Fig. 5e Stabilization of p27^Kip1 in Human PIN.

• A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression

Majumder PK, Grisanzio C, O'Connell F, Barry M, Brito JM, Xu Q, Guney I, Berger R, Herman P, Bikoff R, Fedele G, Baek WK, Wang S, Ellwood-Yen K, Wu H, Sawyers CL, Signoretti S, Hahn WC, Loda M, Sellers WR


• Cancer Cell.
  2008 Aug 12;14(2):146-55.

Fig. 1 Crystal structure of the globular head region of NiV-G.

• Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3.

Xu K, Rajashankar KR, Chan YP, Himanen JP, Broder CC, Nikolov DB


• Proc Natl Acad Sci U S A.
  2008 Jul 22;105(29):9953-8.

Fig. 1 Representative photograph of pancreatic cancer cells demonstrating eGFP expression after vMyxgfp infection with MOI 10.

• Myxoma virus is oncolytic for human pancreatic adenocarcinoma cells.

Woo Y, Kelly KJ, Stanford MM, Galanis C, Shin Chun Y, Fong Y, McFadden G


• Ann Surg Oncol.
  2008 Aug;15(8):2329-35.

Fig. 2h. Detection of apoptotic NY-ESO-1-expressing melanoma cells after CHP-NY-ESO-1 vaccination. Double-labeling of tumor cells undergoing apoptosis is shown by localized, yellow fluorescence (g, h). A significant increase in apoptotic melanoma cells was observed after the third vaccination with CHP-NY-ESO-1 (on day 31).

• Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient

Tsuji K, Hamada T, Uenaka A, Wada H, Sato E, Isobe M, Asagoe K, Yamasaki O, Shiku H, Ritter G, Murphy R, Hoffman EW, Old LJ, Nakayama E, Iwatsuki K


• Cancer Immunol Immunother.
  2008 Oct;57(10):1429-37.

Fig. 5d. Top1cc's induce Brca1-dependent degradation of Top1 without substantial degradation of Pol II. MEF cells of the indicated genotype were treated with 25 µM CPT for the indicated times. Western blotting analyses of Top1 and Pol II. Pol IIa (hypophosphorylated CTD) and Pol IIo (hyperphosphorylated CTD) forms are indicated. Tubulin was used as a loading control. The top panel shows quantification of Top1 expression shown.

• Hyperphosphorylation of RNA Polymerase II in Response to Topoisomerase I Cleavage Complexes and Its Association with Transcription- and BRCA1-dependent Degradation of Topoisomerase I

Sordet O, Larochelle S, Nicolas E, Stevens EV, Zhang C, Shokat KM, Fisher RP, Pommier Y


• J Mol Biol.
  2008 Sep 5;381(3):540-9.

Fig 1d. Adenocarcinoma, histology. Mucinous BAC. The alveolar walls are slightly thickened by fibrosis and chronic inflammation and they are lined by tall columnar cells with basally oriented nuclei and abundant mucin-filled apical cytoplasm (case showed KRAS mutation).

• Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis

Motoi N, Szoke J, Riely GJ, Seshan VE, Kris MG, Rusch VW, Gerald WL, Travis WD


• Am J Surg Pathol.
  2008 Jun;32(6):810-27.

Fig 1. Structural insights to TopIB transesterification chemistry.

• Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis

Yakovleva L, Chen S, Hecht SM, Shuman S


• J Biol Chem.
  2008 283(23):16093-103.

Fig 18b. Muscle lymphoma on ultrasound. On power Doppler image, the mass is hypervascular.

• Imaging of Lymphoma of the Musculoskeletal System

Hwang S


• Radiol Clin North Am.
  2008 Mar;46(2):379-96.

Fig 3. 60-year-old woman with diffuse disease and calcifications in left anterior descending coronary artery (LAD) (arrow) extending into left circumflex artery.

• Coronary artery disease after radiation therapy for Hodgkin's lymphoma: Coronary CT angiography findings and calcium scores in nine asymptomatic patients

Rademaker J, Schöder H, Ariaratnam NS, Strauss HW, Yahalom J, Steingart R, Oeffinger KC


• AJR Am J Roentgenol.
  2008 Jul;191(1):32-7.

Fig 2. Quantitative analysis by BLI of adoptively transferred T-cell persistence and tumor progression in individual animals.

• Monitoring the efficacy of adoptively transferred prostate cancer-targeted human T lymphocytes with PET and bioluminescence imaging

Dobrenkov K, Olszewska M, Likar Y, Shenker L, Gunset G, Cai S, Pillarsetty N, Hricak H, Sadelain M, Ponomarev V


• J Nucl Med.
  2008 Jul;49(7):1162-70.

Fig 11. Leptomeningeal PCNSL.

• Imaging of lymphoma of the central nervous system, spine, and orbit

Haque S, Law M, Abrey LE, Young RJ


• Radiol Clin North Am.
  2008 Mar;46(2):339-61.

Fig 2. All biopsy specimens demonstrated similar changes: mild acanthosis, no hyperkeratosis, basilar hyperpigmentation, and scattered melanophages in papillary dermis.

• Melanosis of the areola and nipple

Sceppa JA, Smith BL, Marghoob AA, Gottlieb GJ


• J Am Acad Dermatol.
  2008 Aug;59(2 Suppl 1):S33-4.

Fig 3a. 18F-FDG PET images of pelvis show intense 18F-FDG uptake within known cervical tumor at site of cervical mass seen on CT.

• An imaging comparison of 64Cu-ATSM and 60Cu-ATSM in cancer of the uterine cervix

Lewis JS, Laforest R, Dehdashti F, Grigsby PW, Welch MJ, Siegel BA


• J Nucl Med.
  2008 Jul;49(7):1177-82.

Fig 6b. Silvestrol synergizes with doxorubicin to induce apoptosis in Pten^+/–Eμ-Myc lymphoma cells in vivo.

• Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model

Bordeleau ME, Robert F, Gerard B, Lindqvist L, Chen SM, Wendel HG, Brem B, Greger H, Lowe SW, Porco JA Jr, Pelletier J


• J Clin Invest.
  2008 Jul;118(7):2651-60.

Fig 4c. Small cell lung cancer of the left pulmonary hilum with an adjacent satellite lung nodule.

• The value of gamma camera and computed tomography data set coregistration to assess Lewis Y antigen targeting in small cell lung cancer by (111)Indium-labeled humanized monoclonal antibody 3S193

Quaia E, Krug LM, Pandit-Taskar N, Nagel A, Reuter VE, Humm J, Divgi C


• Eur J Radiol.
  2008 Aug;67(2):292-9.

Fig 2a. Significant linkage disequilibrium in the region at 6q22.33 associating with breast cancer in AJs.

• Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33

Gold B, Kirchhoff T, Stefanov S, Lautenberger J, Viale A, Garber J, Friedman E, Narod S, Olshen AB, Gregersen P, Kosarin K, Olsh A, Bergeron J, Ellis NA, Klein RJ, Clark AG, Norton L, Dean M, Boyd J, Offit K


• Proc Natl Acad Sci U S A.
  2008 Mar 18;105(11):4340-5.

Fig 5b. Telomere dysfunction in bone marrow of POT1b+/–mTR–/– mice.

• Engineered telomere degradation models dyskeratosis congenita

Hockemeyer D, Palm W, Wang RC, Couto SS, de Lange T


• Genes Dev.
  2008 Jul 1;22(13):1773-85.