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Home Today's science sparks archives
 Today's science sparks archives - July 2009

Today's science sparks archives - July 2009

July 31, 2009

FIG 6. Tryptophan 96 and neighboring residues in the GLTP·N-oleoyl LacCer complex.

FIG 6. Tryptophan 96 and neighboring residues in the GLTP·N-oleoyl LacCer complex.

  • Zhai X, Malakhova ML, Pike HM, Benson LM, Bergen HR 3rd, Sugár IP, Malinina L, Patel DJ, Brown RE

  • J Biol Chem.
    2009 May 15;284(20):13620-8.

July 30, 2009

Fig 2f. Neoplastic melanocytes are highlighted with aid of A103 immunostain.

Fig 2f. Neoplastic melanocytes are highlighted with aid of A103 immunostain.

  • Braga JC, Scope A, Klaz I, Mecca P, González S, Rabinovitz H, Marghoob AA

  • J Am Acad Dermatol.
    2009 Aug;61(2):230-41.

July 29, 2009

Fig 1. Dual-modality imaging using hNET and HSV1-tk reporter genes for monitoring different populations of antigen-specific CTLs.

Fig 1. Dual-modality imaging using hNET and HSV1-tk reporter genes for monitoring different populations of antigen-specific CTLs.

  • Ponomarev V

  • J Nucl Med.
    2009 Jun 12.

July 28, 2009

Fig 6. H&E staining of splenic lymphoma tissue in a p53 KO mouse and a p53/Elf4 DKO mouse, together with representative staining of Mdm2 and p16 protein by IHC.

Fig 6. H&E staining of splenic lymphoma tissue in a p53 KO mouse and a p53/Elf4 DKO mouse, together with representative staining of Mdm2 and p16 protein by IHC.

  • Sashida G, Liu Y, Elf S, Miyata Y, Ohyashiki K, Izumi M, Menendez S, Nimer SD

  • Mol Cell Biol.
    2009 Jul;29(13):3687-99.

July 27, 2009

Fig 1c. Induction of chromosomal translocations in TOS4A cells.

Fig 1c. Induction of chromosomal translocations in TOS4A cells.

  • Brunet E, Simsek D, Tomishima M, DeKelver R, Choi VM, Gregory P, Urnov F, Weinstock DM, Jasin M

  • Proc Natl Acad Sci U S A.
    2009 Jun 30;106(26):10620-5.

July 24, 2009

Fig 2a. Conserved amino acids targeted for alanine scanning in S. pombe Spt4. Location of targeted residues in the Spt4 tertiary structure.

Fig 2a. Conserved amino acids targeted for alanine scanning in S. pombe Spt4. Location of targeted residues in the Spt4 tertiary structure.

  • Schwer B, Schneider S, Pei Y, Aronova A, Shuman S

  • RNA.
    2009 Jul;15(7):1241-50.

July 23, 2009

Fig 4h. Src Enhances Metastasis Survival and Outgrowth in Bone Marrow. Representative TRAP staining. Arrows indicate positive staining.

Fig 4h. Src Enhances Metastasis Survival and Outgrowth in Bone Marrow. Representative TRAP staining. Arrows indicate positive staining.

  • Zhang XH, Wang Q, Gerald W, Hudis CA, Norton L, Smid M, Foekens JA, Massagué J

  • Cancer Cell.
    2009 Jul 7;16(1):67-78.

July 22, 2009

Fig 1. Isolation and characterization of brain metastatic variants. i, GPF+ MDA231-BrM2a cells (arrowheads) arrested in brain capillaries (red, rhodamine dextran) 24 h after intracardiac injection into mice.

Fig 1. Isolation and characterization of brain metastatic variants. i, GPF+ MDA231-BrM2a cells (arrowheads) arrested in brain capillaries (red, rhodamine dextran) 24 h after intracardiac injection into mice.

  • Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA, Massagué J

  • Nature.
    2009 Jun 18;459(7249):1005-9.

July 21, 2009

Fig 4. (A–L) Immunostaining of cytospins containing mononuclear cells from BM aspirates pulled from children with NB stage M.

Fig 4. (A–L) Immunostaining of cytospins containing mononuclear cells from BM aspirates pulled from children with NB stage M.

  • Beiske K, Burchill SA, Cheung IY, Hiyama E, Seeger RC, Cohn SL, Pearson AD, Matthay KK; International neuroblastoma Risk Group Task Force

  • Br J Cancer.
    2009 May 19;100(10):1627-37.

July 20, 2009

Fig 6a. Immunofluorescence microscopy analysis of cDO subcellular localization.

Fig 6a. Immunofluorescence microscopy analysis of cDO subcellular localization.

  • Deshaies F, Diallo DA, Fortin JS, O'Rourke HM, Pezeshki AM, Bellemare-Pelletier A, Raby N, Bédard N, Brunet A, Denzin LK, Thibodeau J

  • Immunology.
    2009 Jul;127(3):408-17.

July 17, 2009

Fig 3a. Expression matrix of 6 genes belonging to the oxidative phosphorylation pathway, which were downregulated in poor outcome tumors.

Fig 3a. Expression matrix of 6 genes belonging to the oxidative phosphorylation pathway, which were downregulated in poor outcome tumors.

  • Sheffer M, Bacolod MD, Zuk O, Giardina SF, Pincas H, Barany F, Paty PB, Gerald WL, Notterman DA, Domany E

  • Proc Natl Acad Sci U S A.
    2009 Apr 28;106(17):7131-6.

July 16, 2009

Fig 3c. Immunofluorescence of Pax3:Fkhr during disease progression (400x).

Fig 3c. Immunofluorescence of Pax3:Fkhr during disease progression (400x).

  • Nishijo K, Chen QR, Zhang L, McCleish AT, Rodriguez A, Cho MJ, Prajapati SI, Gelfond JA, Chisholm GB, Michalek JE, Aronow BJ, Barr FG, Randall RL, Ladanyi M, Qualman SJ, Rubin BP, LeGallo RD, Wang C, Khan J, Keller C

  • Cancer Res.
    2009 Apr 1;69(7):2902-11.

July 15, 2009

Fig 1. Tie2/GFP expression by endothelial cells as visualized by multiphoton fluorescence microscopy.

Fig 1. Tie2/GFP expression by endothelial cells as visualized by multiphoton fluorescence microscopy.

  • Dunphy MP, Entenberg D, Toledo-Crow R, Larson SM

  • Microvasc Res.
    2009 Jun;78(1):51-6.

July 14, 2009

Fig 4. Reciprocal changes in immunohistochemical CPI and cathepsin B staining in MV generated 4 d after s.c. injection of 106 TA3/St mammary carcinoma cells.

Fig 4. Reciprocal changes in immunohistochemical CPI and cathepsin B staining in MV generated 4 d after s.c. injection of 106 TA3/St mammary carcinoma cells.

  • Chang SH, Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, Shih SC, Nagy JA, Joyce J, Bogyo M, Kalluri R, Dvorak HF

  • Cancer Res.
    2009 May 15;69(10):4537-44.

July 13, 2009

Fig 5. Anti-tumor effects of PU-H71 are associated with down-regulation of several Hsp90-regulated malignancy driving proteins.

Fig 5. Anti-tumor effects of PU-H71 are associated with down-regulation of several Hsp90-regulated malignancy driving proteins.

  • Caldas-Lopes E, Cerchietti L, Ahn JH, Clement CC, Robles AI, Rodina A, Moulick K, Taldone T, Gozman A, Guo Y, Wu N, de Stanchina E, White J, Gross SS, Ma Y, Varticovski L, Melnick A, Chiosis G

  • Proc Natl Acad Sci U S A.
    2009 May 19;106(20):8368-73.

July 10, 2009

Fig 1. The lambda epigenetic switch: the Cro gene is transcribed but the repressor gene (cI) is not. An early stage of lytic growth of the phage is shown.

Fig 1. The lambda epigenetic switch: the Cro gene is transcribed but the repressor gene (cI) is not. An early stage of lytic growth of the phage is shown.

  • Ptashne M

  • Curr Biol.
    2009 Mar 24;19(6):R234-41.

July 9, 2009

Fig 3. Waterfall graphs of prostate-specific antigen (PSA) response by cohort.

Fig 3. Waterfall graphs of prostate-specific antigen (PSA) response by cohort.

  • Morris MJ, Pandit-Taskar N, Carrasquillo J, Divgi CR, Slovin S, Kelly WK, Rathkopf D, Gignac GA, Solit D, Schwartz L, Stephenson RD, Hong C, Delacruz A, Curley T, Heller G, Jia X, O'Donoghue J, Larson S, Scher HI

  • J Clin Oncol.
    2009 May 20;27(15):2436-42.

July 8, 2009

Fig 2. TGF-ß induces the expression of NF-B in prostate cancer.

Fig 2. TGF-ß induces the expression of NF-B in prostate cancer.

  • Zhang Q, Helfand BT, Jang TL, Zhu LJ, Chen L, Yang XJ, Kozlowski J, Smith N, Kundu SD, Yang G, Raji AA, Javonovic B, Pins M, Lindholm P, Guo Y, Catalona WJ, Lee C

  • Clin Cancer.
    2009 May 15;15(10):3557-67.

July 7, 2009

Fig 3. miR-26a-expressing murine gliomas (P/26a). (A) Schematic of RCAS-miR constructs; CMV denotes CMV promoter, GFP denotes GFP cassette, and miR denotes miRNA domain.

Fig 3. miR-26a-expressing murine gliomas (P/26a). (A) Schematic of RCAS-miR constructs; CMV denotes CMV promoter, GFP denotes GFP cassette, and miR denotes miRNA domain.

  • Huse JT, Brennan C, Hambardzumyan D, Wee B, Pena J, Rouhanifard SH, Sohn-Lee C, le Sage C, Agami R, Tuschl T, Holland EC

  • Genes Dev.
    2009 Jun 1;23(11):1327-37.

July 6, 2009

Fig 2. Annual Age-adjusted Cancer Incidence and Death Rates for All Sites by Sex, United States, 1975–2005.

Fig 2. Annual Age-adjusted Cancer Incidence and Death Rates for All Sites by Sex, United States, 1975–2005.

  • Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ

  • CA Cancer J Clin.
    2009 Jun 25.

July 2, 2009

Fig 2. Akt-1 expressions in breast cell line MCF-7.

Fig 2. Akt-1 expressions in breast cell line MCF-7.

  • Li R, Dai H, Wheeler TM, Sayeeduddin M, Scardino PT, Frolov A, Ayala GE

  • Clin Cancer Res.
    2009 May 15;15(10):3568-73.

July 1, 2009

Fig 1. Regulation of Foxp3 expression.

Fig 1. Regulation of Foxp3 expression.

  • Lu LF, Rudensky A

  • Genes Dev.
    2009 Jun 1;23(11):1270-82.
Content editor, Sarah Jewell
Last revised: July 31, 2009 9:37 AM EST
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