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 Today's science sparks archives - April to September 2006

Today's science sparks archives - April to September 2006

This page contains images and links to articles previously featured.

September 29, 2006

Fig 2.
Pml loss leads to an increase in pAkt in vivo.

Fig 2. Pml loss leads to an increase in pAkt in vivo.

  • Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP

  • Nature.2006 May 25;441(7092):523-7.

September 28, 2006

FIGURE 4.  FP PET/CT in 50-y-old man with cancer of right oral tongue.

FIGURE 4. FP PET/CT in 50-y-old man with cancer of right oral tongue.

  • Schoder H, Carlson DL, Kraus DH, Stambuk HE, Gonen M, Erdi YE, Yeung HW, Huvos AG, Shah JP, Larson SM, Wong RJ

  • J Nucl Med.2006 May;47(5):755-62.

September 27, 2006

Fig. 10. (a) Axial sections from the kV planning CT (left) and MV CBCT (right) of a patient with nonsmall cell lung carcinoma.

Fig. 10. (a) Axial sections from the kV planning CT (left) and MV CBCT (right) of a patient with nonsmall cell lung carcinoma.

  • Sillanpaa J, Chang J, Mageras G, Yorke E, De Arruda F, Rosenzweig KE, Munro P, Seppi E, Pavkovich J, Amols H

  • Medical Physics.2006;33(9):3489-97.

September 26, 2006

Fig. 1. Max Nitze (1848 to 1906)

Fig. 1. Max Nitze (1848 to 1906)

  • Herr, HW

  • J Urol.2006 Oct;176(4 Pt 1):1313-6.

September 25, 2006

Figure 4. Effects of lysinated-betulonic acid at a concentration of 5.5 × 10-4 M on ex vivo tumor tissues.

Figure 4. Effects of lysinated-betulonic acid at a concentration of 5.5 × 10-4 M on ex vivo tumor tissues.

  • Saxena BB, Zhu L, Hao M, Kisilis E, Katdare M, Oktem O, Bomshteyn A, Rathnam P

  • Bioorg Med Chem. 2006 Sep 15;14(18):6349-58.

September 21, 2006

Fig 1. Schematic diagram of the isolated limb infusion circuit.

Fig 1. Schematic diagram of the isolated limb infusion circuit.

  • Brady MS, Brown K, Patel A, Fisher C, Marx W

  • Ann Surg Oncol.2006 Aug;13(8):1123-9.

September 20, 2006

Fig. 1. Recurrent ovarian adult granulosa cell tumors involving abdominal precaval lymph nodes (blue arrow). White arrow demonstrates right ureter.

Fig. 1. Recurrent ovarian adult granulosa cell tumors involving abdominal precaval lymph nodes (blue arrow). White arrow demonstrates right ureter.

  • Abu-Rustum NR, Restivo A, Ivy J, Soslow R, Sabbatini P, Sonoda Y, Barakat RR, Chi DS

  • Gynecologic Oncology.Volume 103, Issue 1, October 2006, Pages 31-34

September 18, 2006

Figure 1. Follicular lymphoma: mixed population of centrocytes and centroblast (arrow).

Figure 1. Follicular lymphoma: mixed population of centrocytes and centroblast (arrow).

  • Brandao GD, Rose R, McKenzie S, Maslak P, Lin O

  • Cancer Cytopathology. 2006 Aug 25.

September 15, 2006

FIGURE 1. The triphosphate tunnel fold of yeast Cet1 is recapitulated in archaeal and bacterial homologs.

FIGURE 1. The triphosphate tunnel fold of yeast Cet1 is recapitulated in archaeal and bacterial homologs.

  • Chunling Gong, Paul Smith and Stewart Shuman

  • RNA. 2006 Aug;12(8):1468-74.

September 13, 2006

Figure 6. Extent of cellular resistance for mutations identified within the Bcr-Abl kinase domain to imatinib and PD166326.

Figure 6. Extent of cellular resistance for mutations identified within the Bcr-Abl kinase domain to imatinib and PD166326.

  • von Bubnoff N, Veach DR, van der Kuip H, Aulitzky WE, Sanger J, Seipel P, Bornmann WG, Peschel C, Clarkson B, Duyster J

  • Blood 2005 Feb 15;105(4):1652-9.

September 7, 2006

Figure 1. The self-seeding concept of cancer growth and metastasis.

Figure 1. The self-seeding concept of cancer growth and metastasis.

  • Norton L, Massague J

  • Nat Med. 2006 Aug;12(8):875-8.

August 29, 2006

Figure 6. PGE2 produced by tumor cells stimulates CYP19 gene expression in breast adipose stromal and tumor cells.

Figure 6. PGE2 produced by tumor cells stimulates CYP19 gene expression in breast adipose stromal and tumor cells.

  • Subbaramaiah K, Howe LR, Port ER, Brogi E, Fishman J, Liu CH, Hla T, Hudis C, Dannenberg AJ

  • Cancer Res. 2006 May 15;66(10):5504-11.

August 23, 2006

FIG. 2. GFP reporter expression in BAC-Kit-GFP transgenic mice.

FIG. 2. GFP reporter expression in BAC-Kit-GFP transgenic mice.

  • Berrozpe G, Agosti V, Tucker C, Blanpain C, Manova K, Besmer P

  • Mol Cell Biol. 2006 Aug;26(15):5850-60.

August 15, 2006

Figure 1. Characterization of Metastatic Escapers

Figure 1. Characterization of Metastatic Escapers

  • Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B, Brennan C, Hahn WC, Cordon-Cardo C, Wagner SN, Flotte TJ, Duncan LM, Granter SR, Chin L

  • Cell. 2006 Jun 30;125(7):1269-81.

August 9, 2006

Fig 3.

Fig 3.

  • Agero AL, Busam KJ, Benvenuto-Andrade C, Scope A, Gill M, Marghoob AA, Gonzalez S, Halpern AC

  • J Am Acad Dermatol. 2006 Apr;54(4):638-43.

July 30, 2006

Metallophosphoesterase active site.

Metallophosphoesterase active site.

  • Keppetipola N, Shuman S

  • J Biol Chem. 2006 Jul 14;281(28):19251-9.

July 26, 2006

Photomicrographs of Case 1.

Photomicrographs of Case 1.

  • Puri DR, Meyers PA, Kraus DH, Laquaglia MP, Wexler LH, Wolden SL

  • Pediatr Blood Cancer. 2006 Jul 19

July 24, 2006

Fig. 1. Joseph H. Burchenal

Fig. 1. Joseph H. Burchenal

  • Varmus H

  • Science. 2006 May 26;312(5777):1162-5.

July 21, 2006

Riboswitch Grips Vitamin B1 Derivative

  • Serganov A, Polonskaia A, Phan AT, Breaker RR, Patel DJ

  • Nature. 2006 Jun 29;441(7097):1167-71.

July 19, 2006

Figure 3. Defects in Mesoderm Development and Migration in p38IP<sup><em>RRK/RRK</em></sup> Mutant Embryos

Figure 3. Defects in Mesoderm Development and Migration in p38IPRRK/RRK Mutant Embryos

  • Zohn IE, Li Y, Skolnik EY, Anderson KV, Han J, Niswander L

  • Cell. 2006 Jun 2;125(5):957-69.

July 18, 2006

Fig 2. Case 2. A, Agminated melanocytic nevi seen on midlower aspect of patient's back. B, Dermoscopic image showing patchy reticulated network.

Fig 2. Case 2. A, Agminated melanocytic nevi seen on midlower aspect of patient's back. B, Dermoscopic image showing patchy reticulated network.

  • Bragg JW, Swindle L, Halpern AC, Marghoob AA.

  • J Am Acad Dermatol. 2005 Jan;52(1):67-73.

July 17, 2006

MRI data: structural images, FA maps, and fiber reconstruction.

MRI data: structural images, FA maps, and fiber reconstruction.

  • Voss HU, Uluc AM, Dyke JP, Watts R, Kobylarz EJ, McCandliss BD, Heier LA, Beattie BJ, Hamacher KA, Vallabhajosula S, Goldsmith SJ, Ballon D, Giacino JT, Schiff ND.

  • J Clin Invest. 2006 Jul 3;116(7):2005-2011.

July 13, 2006

Figure 2

Figure 2

  • Seetharaman J, Rajashankar KR, Solorzano V, Kniewel R, Lima CD, Bonanno JB, Burley SK, Swaminathan S.

  • Proteins. 2006 Jun 1;63(4):1092-6.

July 11, 2006

PHD Finger Grips Histone Tails

PHD Finger Grips Histone Tails

  • Li H, Ilin S, Wang W, Duncan EM, Wysocka J, Allis CD, Patel DJ

  • Nature. 2006 Jul 6;442(7098):91-5.

July 7, 2006

Genetic analysis of the interface between Ubc9 and RanGAP1

Genetic analysis of the interface between Ubc9 and RanGAP1

  • Yunus AA, Lima CD

  • Nat Struct Mol Biol. 2006 Jun;13(6):491-9.

July 6, 2006

Collaboration between <em>Pten</em> and <em>p18</em> in suppression of pituitary tumors

Collaboration between Pten and p18 in suppression of pituitary tumors

  • Bai F, Pei XH, Pandolfi PP, Xiong Y

  • Mol Cell Biol. 2006 Jun;26(12):4564-76

June 30, 2006

Mean number of regional lymph nodes removed and number of patients with new symptomatic leg lymphedema by year of surgery

Mean number of regional lymph nodes removed and number of patients with new symptomatic leg lymphedema by year of surgery

  • Abu-Rustum NR, Alektiar K, Iasonos A, Lev G, Sonoda Y, Aghajanian C, Chi DS, Barakat RR

  • Gynecol Oncol. 2006 May 30.

June 29, 2006

Representative electron micrographs of ultrastructural changes in kidneys of different experimental groups of mice at 40 weeks after actinium injection

Representative electron micrographs of ultrastructural changes in kidneys of different experimental groups of mice at 40 weeks after actinium injection

  • Jaggi JS, Seshan SV, McDevitt MR, Sgouros G, Hyjek E, Scheinberg DA

  • Int J Radiat Oncol Biol Phys. 2006 Apr 1;64(5):1503-12.

June 28, 2006

Intensity-modulated radiotherapy (IMRT) “dose painting” for dose escalation within planning treatment volumes

Intensity-modulated radiotherapy (IMRT) “dose painting” for dose escalation within planning treatment volumes

  • Goodman KA, Toner S, Hunt M, Wu EJ, Yahalom J

  • Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):198-206

June 27, 2006

PDGFRα and PDGFRβ expression is specifically upregulated in human late stage mammary tumors

PDGFRα and PDGFRβ expression is specifically upregulated in human late stage mammary tumors

  • Jechlinger M, Sommer A, Moriggl R, Seither P, Kraut N, Capodiecci P, Donovan M, Cordon-Cardo C, Beug H, Grunert S

  • J Clin Invest. 2006 Jun;116(6):1561-70.

June 26, 2006

Transient expression of BRC-RPA fusion proteins increases HDR in <em>Brca2</em> mutant cells

Transient expression of BRC-RPA fusion proteins increases HDR in Brca2 mutant cells

  • Saeki H, Siaud N, Christ N, Wiegant WW, van Buul PP, Han M, Zdzienicka MZ, Stark JM, Jasin M

  • Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8768-73.

June 23, 2006

Serous adenocarcinoma invading diaphragm muscle

Serous adenocarcinoma invading diaphragm muscle

  • Dos Santos LA, Modica I, Flores RM, D'Angelica M, Aghajanian C, Chi DS, Abu-Rustum NR

  • Gynecol Oncol. 2006 Jun 16.

June 22, 2006

Comparison of age-specific penetrance estimates of melanoma for CDKN2A mutation carriers

Comparison of age-specific penetrance estimates of melanoma for CDKN2A mutation carriers

  • Begg CB, Orlow I, Hummer AJ, Armstrong BK, Kricker A, Marrett LD, Millikan RC, Gruber SB, Anton-Culver H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Mitra N, Busam K, From L, Berwick M; Genes Environment and Melanoma Study Group

  • J Natl Cancer Inst. 2005 Oct 19;97(20):1507-15.

June 21, 2006

Overall related structure of PIK3CG with corresponding PIK3CA mutated residues identified in parentheses

Overall related structure of PIK3CG with corresponding PIK3CA mutated residues identified in parentheses

  • Levine DA, Bogomolniy F, Yee CJ, Lash A, Barakat RR, Borgen PI, Boyd J

  • Clin Cancer Res. 2005 Apr 15;11(8):2875-8.

June 20, 2006

Analysis of the three functional domains of Cds1 by mutagenesis

Analysis of the three functional domains of Cds1 by mutagenesis

  • Xu YJ, Davenport M, Kelly TJ

  • Genes Dev. 2006 Apr 15;20(8):990-1003.

June 19, 2006

RCAS-PyMT induces liver tumors in albumin-tv-a transgenic mice

RCAS-PyMT induces liver tumors in albumin-tv-a transgenic mice

  • Lewis BC, Klimstra DS, Socci ND, Xu S, Koutcher JA, Varmus HE

  • Mol Cell Biol. 2005 Feb;25(4):1228-37.

June 16, 2006

Injection of alcohol into the right plexus

Injection of alcohol into the right plexus

  • Strong VE, Dalal KM, Malhotra VT, Cubert JH, Coit D, Fong Y, Allen PJ

  • J Am Coll Surg. 2006 Jul;203(1):129-31.

June 15, 2006

Isolation and Characterization of hESMPCs

Isolation and Characterization of hESMPCs

  • Barberi T, Willis LM, Socci ND, Studer L

  • PLoS Med. 2005 Jun;2(6):e161.

June 13, 2006

Lung opacities disappear in MR images, and the tumors regress histologically in the lungs of bitransgenic mice after withdrawal of doxycycline.

Lung opacities disappear in MR images, and the tumors regress histologically in the lungs of bitransgenic mice after withdrawal of doxycycline

  • Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE

  • Genes Dev. 2006 Jun 1;20(11):1496-510.

June 12, 2006

Expression of TIF1γ and Activated Smad2/3 in Mouse and Human Hematopoietic Tissues

Expression of TIF1γ and Activated Smad2/3 in Mouse and Human Hematopoietic Tissues

  • He W, Dorn DC, Erdjument-Bromage H, Tempst P, Moore MA, Massague J

  • Cell. 2006 Jun 2;125(5):929-41.

June 9, 2006

Tissue microarray of colorectal carcinomas consisting of 72 cores.

Tissue microarray of colorectal carcinomas consisting of 72 cores

  • Korabiowska M, Cordon-Cardo C, Schinagl M, Karaus M, Stachura J, Schulz H, Fischer G

  • Hum Pathol. 2006 Apr;37(4):448-52.

June 7, 2006

Unsupervised hierarchical clustering and principal component analysis

Unsupervised hierarchical clustering and principal component analysis

  • Villanueva J, Shaffer DR, Philip J, Chaparro CA, Erdjument-Bromage H, Olshen AB, Fleisher M, Lilja H, Brogi E, Boyd J, Sanchez-Carbayo M, Holland EC, Cordon-Cardo C, Scher HI, Tempst P

  • J Clin Invest. 2006 Jan;116(1):271-84.

June 6, 2006

Hematopoietic recovery after treatment with myelotoxic agents

Hematopoietic recovery after treatment with myelotoxic agents

  • H. Daniel Lacorazza, Takeshi Yamada, Yan Liu, Yasuhiko Miyata, Mariela Sivina, Juliana Nunes and Stephen D. Nimer

  • Cancer Cell. 2006 Mar;9(3):175-87.

June 4, 2006

NV1066 spreads across cavities, infects metastases and express GFP.

NV1066 spreads across cavities, infects metastases and express GFP

  • Adusumilli PS, Stiles BM, Chan MK, Eisenberg DP, Yu Z, Stanziale SF, Huq R, Wong RJ, Rusch VW, Fong Y.

  • FASEB J. 2006 April; 20(6): 726–728

May 31, 2006

Vascular defects

Vascular defects

  • Vidal A, Zacharoulis S, Guo W, Shaffer D, Giancotti F, Bramley AH, de la Hoz C, Jensen KK, Kato D, MacDonald DD, Knowles J, Yeh N, Frohman LA, Rafii S, Lyden D, Koff A.

  • Proc Natl Acad Sci U S A. 2005 May 10;102(19):6890-5

May 25, 2006

Lung Adenocarcinoma

Re-Biopsy Studies

  • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H

  • (2005) PLoS Med 2(3): e73

April 10, 2006

Myotubes formed in vitro

Myotubes formed in vitro

  • Silvia Monticelli, K Mark Ansel, Changchun Xiao, Nicholas D Socci, Anna M Krichevsky, To-Ha Thai, Nikolaus Rajewsky, Debora S Marks, Chris Sander, Klaus Rajewsky, Anjana Rao and Kenneth S Kosik

  • Genome Biology 2005, 6:R71

April 7, 2006

Lyphoma update

Acute myelocytic
leukemia (AML)

  • Reported by Lynette Grouse and Mike Miller
  • National Cancer Institute’s BenchMarks, June 22, 2005

Content editor, Sarah Jewell
Last revised: July 6, 2008 2:26 PM EST
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