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Today's science sparks archives - October to December 2007
Today's science sparks archives - October to December 2007
This page contains images and links to articles previously featured.
December 28, 2007
Fig 4C. Control uninjected Xenopus embryos and embryos injected with the indicated reagents are shown (side view) with the head to the left.
Joo HY, Zhai L, Yang C, Nie S, Erdjument-Bromage H, Tempst P, Chang C, Wang H
Nature. 2007 Oct 25;449(7165):1068-72.
December 26, 2007
Fig 6A. α SGT is predicted to interact with a short peptide sequence in the AR hinge that structurally resembles the COOH-terminal EEVD peptides from Hsp70 and Hsp90.
Buchanan G, Ricciardelli C, Harris JM, Prescott J, Yu ZC, Jia L, Butler LM, Marshall VR, Scher HI, Gerald WL, Coetzee GA, Tilley WD
Cancer Res. 2007 Oct 15;67(20):10087-96.
December 21, 2007
Fig 1B. The anatomy of the meninges as it surrounds the spinal cord.
O'Meara WP, Borkar SA, Stambuk HE, Lymberis SC
Curr Probl Cancer. 2007 Nov-Dec;31(6):372-424.
December 20, 2007
Fig 1E. Postoperative posterior view. Note well-healed donor site.
Cordeiro CN, McCarthy CM, Mastorakos DP, Cordeiro PG
Ann Plast Surg. 2007 Oct;59(4):451-2.
December 19, 2007
Fig 1D. Confocal microscopic immunofluorescent image of hyperplastic islet cells revealed TVA (red) and PDX1 (green) in pancreatic section of a 7-wk-old
RIP-Tag; RIP-tva bitransgenic animal.
Du YC, Lewis BC, Hanahan D, Varmus H
PLoS Biol. 2007 Oct 16;5(10):2255-69.
December 18, 2007
Fig 5. Modified technique for nerve-sparing surgery.
James A. Eastham
Nat Clin Pract Urol. 2007 Oct;4(10):561-9.
December 17, 2007
Fig 1A. Ribbon diagram of the Rad4–Rad23–DNA complex: TGD, gold; BHD1, magenta; BHD2, cyan; BHD3, red; R4BD, green; and DNA, grey. The two disordered CPD-linked thymidines are indicated schematically, and the two flipped-out thymidines bound to Rad4 are coloured black. Dotted lines indicate disordered regions.
Min JH, Pavletich NP
Nature. 2007 Oct 4;449(7162):570-5.
December 14, 2007
Fig 2. Patient with non–small cell lung cancer and increasing metastatic disease with new lung and liver (not shown) lesions.
Gollub MJ, Hong R, Sarasohn DM, Akhurst T
J Nucl Med. 2007 Oct;48(10):1583-91.
December 13, 2007
Fig 4B. Coexpression of phospho-RTKs in cells dissociated from primary GBM MSK199.
Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA
Science. 2007 Oct 12;318(5848):287-90.
December 12, 2007
Fig 1A. Photomicrograph (×40) of cytokeratin AE1:AE3 immunostain showing the dispersed distribution of metastatic clusters along the subcapsular sinuses of nearly the entire circumference of the lymph node.
Moore KH, Sweeney KJ, Wilson ME, Goldberg JI, Buchanan CL, Tan LK, Liberman L, Turner RR, Lagios MD, Cody Iii HS, Giuliano AE, Silverstein MJ, Van Zee KJ
Ann Surg Oncol. 2007 Oct;14(10):2911-7.
December 11, 2007
Fig 1. Mechanisms of resistance to targeted cancer therapy.
Charles L. Sawyers
Nat Med. 2007 Oct;13(10):1144-5.
December 10, 2007
Fig 3. Isodose plot from a treatment plan of a paraspinal tumor.
Mageras GS, Mechalakos J
Semin Radiat Oncol. 2007 Oct;17(4):268-77.
December 7, 2007
Fig 2C. Reactions catalysed by ribozymes.
Serganov A, Patel DJ
Nat Rev Genet. 2007 Oct;8(10):776-90.
December 6, 2007
Fig 6. Granulation tissue showing plump endothelial cells resembling atypical epithelial cells in a fibroblastic stroma.
Berney DM, Fisher G, Kattan MW, Oliver RT, Møller H, Fearn P, Eastham J, Scardino P, Cuzick J, Reuter VE, Foster CS; Trans-Atlantic prostate group
Histopathology. 2007 Oct;51(4):452-7.
December 5, 2007
Fig 1. Components of bone marrow.
Hwang S, Panicek DM
Skeletal Radiol. 2007 Oct;36(10):913-20.
December 4, 2007
Fig 2. An axial slice of a computed tomographic scan through the region of the optic chiasm demonstrating tumor underdose near the optic chiasm.
Nancy Y. Lee
Int J Radiat Oncol Biol Phys. 2007;69(2 Suppl):S43-5.
December 3, 2007
Fig 2. The lung shows alveolar edema and fibrin accumulation with early hyaline membrane formation with the pattern of diffuse alveolar damage.
Liu V, White DA, Zakowski MF, Travis W, Kris MG, Ginsberg MS, Miller VA, Azzoli CG
Chest. 2007 Sep;132(3):1042-4.
November 30, 2007
Fig 4. Cleavage of the Eph-bound ephrins allows for signaling termination and cell separation/repulsion.
Himanen JP, Saha N, Nikolov DB
Curr Opin Cell Biol. 2007 Oct;19(5):534-42.
November 29, 2007
Fig 1. Anatomic retroperitoneal nodal regions.
Carver BS, Shayegan B, Eggener S, Stasi J, Motzer RJ, Bosl GJ, Sheinfeld J
J Clin Oncol. 2007 Oct 1;25(28):4365-9.
November 28, 2007
Fig 7B. Subcellular localization of PRL1.
Sun JP, Luo Y, Yu X, Wang WQ, Zhou B, Liang F, Zhang ZY
J Biol Chem. 2007 Sep 28;282(39):29043-51.
November 27, 2007
Fig 2. Herpes simplex virus lytic cycle.
Reinblatt M, Pin RH, Fong Y
J Am Coll Surg. 2007 Oct;205(4)Supp1:S69-S75.
November 26, 2007
Cover Image - Nov 2007
Avital I, Moreira AL, Klimstra DS, Leversha M, Papadopoulos EB, Brennan M, Downey RJ
Stem Cells. 2007 Nov;25(11):2903-9.
November 21, 2007
Fig 5. Exo84 genetically interacts with apical and basolateral components.
Blankenship JT, Fuller MT, Zallen JA
J Cell Sci. 2007 Sep 1; 17(120):3099-3110.
November 20, 2007
Fig 1B. The proposed mechanism of action for the BAR reporter involves Akt-dependent phosphorylation of the Aktpep domain (thick line), which results in its interaction with the FHA2 domain (right).
Zhang L, Lee KC, Bhojani MS, Khan AP, Shilman A, Holland EC, Ross BD, Rehemtulla A
Nat Med. 2007 Sep;13(9):1114-9.
November 19, 2007
Fig 2. Schematic model of gA channel formation in lipid bilayers.
Ingolfsson HI, Koeppe RE II, Andersen OS
Biochemistry. 2007 Sep 11;46(36):10384-91.
November 16, 2007
Fig 1D. Tumor-associated B7-H3 and B7x.
Zang X, Allison JP
Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5271-9.
November 15, 2007
Fig 3A. Fluorescent immunohistochemical (IHC) staining for G-CSF protein was performed in the human ES cell lines TC71, SK-ES, and A4573 and compared with a normal human osteoblast cell line.
Morales-Arias J, Meyers PA, Bolontrade MF, Rodriguez N, Zhou Z, Reddy K, Chou AJ, Koshkina NV, Kleinerman ES
Cancer. 2007 Oct 1;110(7):1568-77.
November 14, 2007
Fig 1. Experimental design. Adult male rhesus macaques were used to test the effects of busulfan on spermatogenesis and the SSC pool.
Hermann BP, Sukhwani M, Lin CC, Sheng Y, Tomko J, Rodriguez M, Shuttleworth JJ, McFarland D, Hobbs RM, Pandolfi PP, Schatten GP, Orwig KE
Stem Cells. 2007 Sep;25(9):2330-8.
November 13, 2007
Fig 1. Murray F. Brennan.
Coit, Daniel
J Am Coll Surg. 2007 Oct;205(4 Suppl):S54-8.
November 12, 2007
Fig 1. Sequential use of tyrosine kinase inhibitors can select for cells harboring compound kinase domain mutations.
Shah NP, Skaggs BJ, Branford S, Hughes TP, Nicoll JM, Paquette RL, Sawyers CL
J Clin Invest. 2007 Sep;117(9):2562-9.
November 9, 2007
Fig 5. Bioluminescent imaging of NALM-6(GFP-FFLuc) tumor cells after weekly CAR+ T-cell treatment for 4 wks.
Brentjens RJ, Santos E, Nikhamin Y, Yeh R, Matsushita M, La Perle K, Quintás-Cardama A, Larson SM, Sadelain M
Clin Cancer Res. 2007 Sep 15;13(18):5426-35.
November 8, 2007
Fig 5. High-dose IgG protects animals against delayed radiation nephropathy while preserving the therapeutic effect of 225Ac-A33.
Jaggi JS, Carrasquillo JA, Seshan SV, Zanzonico P, Henke E, Nagel A, Schwartz J, Beattie B, Kappel BJ, Chattopadhyay D, Xiao J, Sgouros G, Larson SM, Scheinberg DA
J Clin Invest. 2007 Sep;117(9):2422-30.
November 7, 2007
Fig 2. Predicted Interactions Verified by IP-MS.
Betel D, Breitkreuz KE, Isserlin R, Dewar-Darch D, Tyers M, Hogue CW
PLoS Comput Biol. 2007 Sep 21;3(9):1783-9.
November 6, 2007
Fig 4. The Platform-Binding Center for Folded 5´-UTR mRNAs.
Marzi S, Myasnikov AG, Serganov A, Ehresmann C, Romby P, Yusupov M, Klaholz BP
Cell. 2007 Sep 21;130(6):1019-31.
November 5, 2007
Fig 1B. Immunostaining of FKHR; BPH showing weak cytoplasmic expression.
Li R, Erdamar S, Dai H, Wheeler TM, Frolov A, Scardino PT, Thompson TC, Ayala GE
Hum Pathol. 2007 Oct;38(10):1501-7.
November 2, 2007
Fig 1. Imaging level shown in vertical histology schematic.
Scope A, Benvenuto-Andrade C, Agero AL, Malvehy J, Puig S, Rajadhyaksha M, Busam KJ, Marra DE, Torres A, Propperova I, Langley RG, Marghoob AA, Pellacani G, Seidenari S, Halpern AC, Gonzalez S
J Am Acad Dermatol. 2007 Oct;57(4):644-58.
November 1, 2007
Fig 1B. Isodose curves of seven-field, dose-painting, intensity-modulated radiotherapy plan for patient with Stage T3N2c supraglottic carcinoma; sagittal view.
Lee NY, O'Meara W, Chan K, Della-Bianca C, Mechalakos JG, Zhung J, Wolden SL, Narayana A, Kraus D, Shah JP, Pfister DG
Int J Radiat Oncol Biol Phys. 2007 Oct 1;69(2):459-68.
October 31, 2007
Fig 1. Histological features of placental site trophoblastic tumor (hematoxylin–eosin stain).
Hui P, Wang HL, Chu P, Yang B, Huang J, Baergen RN, Sklar J, Yang XJ, Soslow RA
Mod Pathol. 2007 Oct;20(10):1055-60.
October 30, 2007
Fig 4. Removal of the left adrenal gland.
Charlotte Ariyan and Vivian E. Strong
Adv Surgery. 2007;41:133-53.
October 29, 2007
Fig 5. Active site similarity between Pnkp phosphatase and CTD serine phosphatase.
Zhu H, Smith P, Wang LK, Shuman S
Virology. 2007 Sep 15;366(1):126-36.
October 26, 2007
Fig 1. The Genomic Instability of Cancers Is Important Both in the Evolution of Their Malignant Phenotype and in Providing Potential Targets for Immune-Based Therapeutics.
Peggs KS, Segal NH, Allison JP
Cancer Cell. 2007 Sep;12(3):192-9.
October 25, 2007
Fig 1. Patterns of Genomic Homozygosity and Heterozygosity in ES Cells Derived by Nuclear Transfer and Parthenogenesis from F1 Hybrid Mice.
Kim K, Ng K, Rugg-Gunn PJ, Shieh JH, Kirak O, Jaenisch R, Wakayama T, Moore MA, Pedersen RA, Daley GQ
Cell Stem Cell. 2007 Sep 13; 1(3):346-352.
October 24, 2007
Fig 1. Control of the LacZ gene in E. coli.
Mark Ptashne
Current Biology. 2007 Sep 4; 17(17):R740-R741.
October 23, 2007
Fig1B. Diffuse and strong positivity for CD99 (O13 antibody).
Wang L, Bhargava R, Zheng T, Wexler L, Collins MH, Roulston D, Ladanyi M
J Mol Diagn. 2007 Sep;9(4):498-509.
October 22, 2007
Fig 2. IVAMS procedure.
Moreno P, Francos JM, Shaha A, Bosch A, de Lama E, Rafecas A, Jaurrieta E
Surgery. 2007 Sep;142(3):410-3.
October 19, 2007
Fig 3B. Slx8 foci colocalize with replication foci as marked with CFP-Pol30; colocalization is indicated by arrows.
Burgess RC, Rahman S, Lisby M, Rothstein R, Zhao X
Mol Cell Biol. 2007 Sep;27(17):6153-62.
October 18, 2007
Fig 2C. Histopathology (×200) shows intraepidermal collections of atypical lymphocytes or Pautrier's microabscesses and scattered epidermotropic lymphocytes.
Agero AL, Gill M, Ardigo M, Myskowski P, Halpern AC, González S
J Am Acad Dermatol. 2007 Sep;57(3):435-41.
October 17, 2007
Fig 1. Breast applicator and lead shielding for intraoperative radiotherapy.
Beal K, McCormick B, Zelefsky MJ, Borgen P, Fey J, Goldberg J, Sacchini V
Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):19-24.
October 16, 2007
Fig 6A. Histologic sections of macrofollicular variant of papillary carcinoma.
Chung D, Ghossein RA, Lin O
Diagn Cytopathol. 2007 Sep;35(9):560-4.
October 15, 2007
Fig 2. Representative photomicrographs of BRCA2-linked tissue specimens before and after laser catapult microdissection.
King TA, Li W, Brogi E, Yee CJ, Gemignani ML, Olvera N, Levine DA, Norton L, Robson ME, Offit K, Borgen PI, Boyd J
Ann Surg Oncol. 2007 Sep;14(9):2510-8.
October 12, 2007
Fig 1. A rotational fluoroscopy image of a hepatic artery injection.
Coleman J, Nascimento R, Solomon SB
Nat Clin Pract Urol. 2007 Sep;4(9):498-504.
October 11, 2007
Fig 2. Schematic depiction of transcriptional regulation by post-translational histone modifications.
Wang GG, Allis CD, Chi P
Trends Mol Med. 2007 Sep;13(9):363-72.
October 10, 2007
Fig 1G. Anti-CD34 staining (brown) of peritubular/interstitial mouse cells, which remain CD34+ (inset, green staining) following in vitro expansion.
Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S
Nature. 2007 Sep 20;449(7160):346-50.
October 9, 2007
Fig 4. NUP98-HOXA9 protein is resistant to ubiquitination.
Moore MA, Chung KY, Plasilova M, Schuringa JJ, Shieh JH, Zhou P, Morrone G
Ann N Y Acad Sci. 2007 June;1106:11.
October 8, 2007
Fig 1. FC and FCM arrangements during myoblast fusion.
Beckett K, Baylies MK
Dev Biol. 2007 Sep 1;309(1):113-25.
October 5, 2007
Fig 1C-D. Examples of clinically significant and insignificant tumor foci in 4 patients; Step-sections from patients 5 and 4, respectively.
Pucar D, Hricak H, Shukla-Dave A, Kuroiwa K, Drobnjak M, Eastham J, Scardino PT, Zelefsky MJ
Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):62-9.
October 4, 2007
Fig 1. Transition structures and activation enthalpies, in italics, for cycloadditions of 1-siloxy-3-methyl-1,3-butadiene with ethylene, butadiene, butenyne, 1-silylbutenyne, acrolein, and -silylethynyl acrolein.
Min SJ, Jones GO, Houk KN, Danishefsky SJ
J Am Chem Soc. 2007 Aug 22;129(33):10078-9.
October 3, 2007
Fig 6A. Model of the HP1γ chromodomain (displayed as a ribbon beneath a transparent surface) bound to G9a K165me3 peptide.
Sampath SC, Marazzi I, Yap KL, Sampath SC, Krutchinsky AN, Mecklenbräuker I, Viale A, Rudensky E, Zhou MM, Chait BT, Tarakhovsky A
Mol Cell. 2007 Aug 17;27(4):596-608.
October 2, 2007
Fig 1A. Representative fluorescence overlay image [pimonidazole (green), Hoechst 33342 (blue), and CA9 (red)] of a section from a macroscopic s.c. xenograft derived from the human colorectal carcinoma cell line HT29.
Li XF, Carlin S, Urano M, Russell J, Ling CC, O'Donoghue JA
Cancer Res. 2007 Aug 15;67(16):7646-53.
October 1, 2007
Fig 1. Cancer immunoediting: from immunosurveillance to immunoevasion.
Rescigno M, Avogadri F, Curigliano G
Biochim Biophys Acta 2007 Sep;1776(1):108-23.
Content editor,
Sarah Jewell
Last revised:
July 6, 2008 2:18 PM
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