Sinha KM, Stephanou NC, Unciuleac MC, Glickman MS, Shuman S
Biochemistry. 2008 Sep 9;47(36):9355-64.
September 26, 2008
Fig 1. Orthogonal film based implant evaluation. Surgical clips identified for cavity delineation and dummy sources were placed in catheters for subsequent position digitization.
Arthur DW, Winter K, Kuske RR, Bolton J, Rabinovitch R, White J, Hanson WF, Wilenzick RM, McCormick B
Int J Radiat Oncol Biol Phys. 2008 Oct 1;72(2):467-73.
September 25, 2008
Fig. 3b. Covariation of CD8 and SHP-1 levels limits the frequencies of hypo- and hyperresponsive cells. Computer model for T cell activation demonstrate how the EC50 for ppERK responsiveness is determined by both CD8 and SHP-1 levels.
Fig. 1. Transformation with plasmids carrying wild type (wt) human CHEK2, as well as the Y424H variant, represses the normally reduced viability due to Rad53 deletion in the Rad53-null sml1-null yeast S. cerevisiae.
Tischkowitz MD, Yilmaz A, Chen LQ, Karyadi DM, Novak D, Kirchhoff T, Hamel N, Tavtigian SV, Kolb S, Bismar TA, Aloyz R, Nelson PS, Hood L, Narod SA, White KA, Ostrander EA, Isaacs WB, Offit K, Cooney KA, Stanford JL, Foulkes WD
Cancer Lett. 2008 Oct 18;270(1):173-180.
September 18, 2008
Fig 2. Histologic examination of the tumor revealed discrete lobules of angiomatous tissue with inflammatory cells to the level of the muscular layer of the lower lip.
Kumar A, Joo WS, Meinke G, Moine S, Naumova EN, Bullock PA
J Virol. 2008 Sep;82(17):8849-62.
September 12, 2008
Fig. 1b. Schematic representation of how to submit trachelectomy margin at the time of frozen-section analysis. Trachelectomy opened after shave showing grossly visible tumor; distance to margin is measured grossly.
Park KJ, Soslow RA, Sonoda Y, Barakat RR, Abu-Rustum NR
Gynecol Oncol. 2008 Sep;110(3):316-23.
September 11, 2008
Fig. 4c. Assessment of LLC Tumor Volume, Microvessel Density, Necrosis, and Long-Term Tumor Growth in Mice Treated with Paclitaxel or Gemcitabine in Combination with DC101C57BL/6 mice bearing 500 mm3 LLC tumors were treated with paclitaxel (PTX) or gemcitabine (GEM) with or without DC101 administered 24 hr prior to the chemotherapy drug.
D'Ambrosio N, Soohoo S, Warshall C, Johnson A, Karimi S
AJR Am J Roentgenol. 2008 Aug;191(2):589-97.
August 29, 2008
Fig. 2b. OP conjugation to TFO/LNA restricts OP cleavage activity to a limited number of genomic sites. Colocalization of phosphoH2AX and 53BP1foci, 24 h after OP-19-mer TFO/LNA transfection.
Woo Y, Kelly KJ, Stanford MM, Galanis C, Shin Chun Y, Fong Y, McFadden G
Ann Surg Oncol. 2008 Aug;15(8):2329-35.
August 21, 2008
Fig. 2h. Detection of apoptotic NY-ESO-1-expressing melanoma cells after CHP-NY-ESO-1 vaccination. Double-labeling of tumor cells undergoing apoptosis is shown by localized, yellow fluorescence (g, h). A significant increase in apoptotic melanoma cells was observed after the third vaccination with CHP-NY-ESO-1 (on day 31).
Tsuji K, Hamada T, Uenaka A, Wada H, Sato E, Isobe M, Asagoe K, Yamasaki O, Shiku H, Ritter G, Murphy R, Hoffman EW, Old LJ, Nakayama E, Iwatsuki K
Cancer Immunol Immunother. 2008 Oct;57(10):1429-37.
August 19, 2008
Fig. 5d. Top1cc's induce Brca1-dependent degradation of Top1 without substantial degradation of Pol II. MEF cells of the indicated genotype were treated with 25 µM CPT for the indicated times. Western blotting analyses of Top1 and Pol II. Pol IIa (hypophosphorylated CTD) and Pol IIo (hyperphosphorylated CTD) forms are indicated. Tubulin was used as a loading control. The top panel shows quantification of Top1 expression shown.
Sordet O, Larochelle S, Nicolas E, Stevens EV, Zhang C, Shokat KM, Fisher RP, Pommier Y
J Mol Biol. 2008 Sep 5;381(3):540-9.
August 18, 2008
Fig 1d. Adenocarcinoma, histology. Mucinous BAC. The alveolar walls are slightly thickened by fibrosis and chronic inflammation and they are lined by tall columnar cells with basally oriented nuclei and abundant mucin-filled apical cytoplasm (case showed KRAS mutation).
Fig 3. 60-year-old woman with diffuse disease and calcifications in left anterior descending coronary artery (LAD) (arrow) extending into left circumflex artery.
Fig 2. All biopsy specimens demonstrated similar changes: mild acanthosis, no hyperkeratosis, basilar hyperpigmentation, and scattered melanophages in papillary dermis.
Gold B, Kirchhoff T, Stefanov S, Lautenberger J, Viale A, Garber J, Friedman E, Narod S, Olshen AB, Gregersen P, Kosarin K, Olsh A, Bergeron J, Ellis NA, Klein RJ, Clark AG, Norton L, Dean M, Boyd J, Offit K
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4340-5.
August 1, 2008
Fig 5b. Telomere dysfunction in bone marrow of POT1b+/–mTR–/– mice.
Wolden SL, Barker CA, Kushner BH, Bodduluri H, Della-Biancia C, Kramer K, Modak S, Cheung NK
Pediatr Blood Cancer. 2008 Jun;50(6):1163-8.
July 24, 2008
Fig 10e. FDG PET/CT performed on a 50 year old woman with newly diagnosed invasive ductal carcinoma of the right breast with palpable right axillary nodes.
Fig 1c. Bone marrow samples of CML patients in chronic phase (n = 81) were stained with anti-PML antibody (brown) and anti-CD34 (red). Insets show PML-staining in blasts (B) and differentiated neutrophils (N).
Shmelkov SV, Butler JM, Hooper AT, Hormigo A, Kushner J, Milde T, St Clair R, Baljevic M, White I, Jin DK, Chadburn A, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, D'Angelica M, Kemeny N, Lyden D, Rafii S
J Clin Invest. 2008 Jun;118(6):2111-20.
July 16, 2008
Fig 1b. Promyelocytic leukemia zinc-finger gene (PLZF) is phosphorylated in vivo and in vitro by cyclin-dependent kinase-2 (CDK2).
Fig. 1 The figure shows the typical radiographic appearance of low-grade juxtacortical osteogenic sarcoma demonstrating a lobulated ossific mass on the surface of the bone.
Hematol Oncol Clin North Am. 2008 Jun;22(3):489-507.
July 7, 2008
Fig 5. Dcr-2- and AGO2-Deficient Cells Exhibit Increased Levels of TE Transcripts. Relative RNA levels (mean ± SD) are shown.(A) TE transcripts were measured by quantitative RT-PCR of S2 cells treated with dsRNA against Dcr-2 or AGO2, normalized to GFP dsRNA-treated cells.
Fig 2a. In non-neoplastic renal tissue adjacent to tumor, PSMA was exclusively expressed in the epithelial cells of the proximal tubules and absent in native renal vessels, glomeruli and stroma.
Today's science sparks archives
Today's science sparks archives - July to September 2008
