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 Today's science sparks archives - January to March 2009

Today's science sparks archives - January to March 2009

This page contains images and links to articles previously featured.

March 31, 2009

Fig 1a. CT antigen expression in hepatobiliary carcinomas.

Fig 1a. CT antigen expression in hepatobiliary carcinomas.

  • Riener MO, Wild PJ, Soll C, Knuth A, Jin B, Jungbluth A, Hellerbrand C, Clavien PA, Moch H, Jochum W

  • Int J Cancer.
    2009 Jan 15;124(2):352-7.

March 30, 2009

Fig 7c. Model of positive regulation of DNA-damage-induced oligomerization of Rad9 dimers via BRCT-SCD interaction.

Fig 7c. Model of positive regulation of DNA-damage-induced oligomerization of Rad9 dimers via BRCT-SCD interaction.

  • Usui T, Foster SS, Petrini JH

  • Mol Cell.
    2009 Jan 30;33(2):147-59.

March 27, 2009

Fig 7. Interaction between MreB and Topo IV May Help Coordinate Late Cell-Cycle Events.

Fig 7. Interaction between MreB and Topo IV May Help Coordinate Late Cell-Cycle Events.

  • Madabhushi R, Marians KJ

  • Mol Cell.
    2009 Jan 30;33(2):171-80.

March 26, 2009

Fig 1. Hyperplasia of ICC in the stomachs of Kit V558 delta /+ mice.

Fig 1. Hyperplasia of ICC in the stomachs of KitV558Δ/+ mice.

  • Kwon JG, Hwang SJ, Hennig GW, Bayguinov Y, McCann C, Chen H, Rossi F, Besmer P, Sanders KM, Ward SM

  • Gastroenterology.
    2009 Feb;136(2):630-9.

March 25, 2009

Fig 3. Effect of rMETase with or without vincristine on cell cycle arrest of SK-N-BE(2)C.

Fig 3. Effect of rMETase with or without vincristine on cell cycle arrest of SK-N-BE(2)C.

  • Hu J, Cheung NK

  • Int J Cancer.
    2009 Apr 1;124(7):1700-6.

March 24, 2009

Fig 1a.  Isodose curves and dose–volume histogram of T2N1M0 oral tongue cancer with negative margins treated with dose-painting technique.

Fig 1a. Isodose curves and dose–volume histogram of T2N1M0 oral tongue cancer with negative margins treated with dose-painting technique.

  • Gomez DR, Zhung JE, Gomez J, Chan K, Wu AJ, Wolden SL, Pfister DG, Shaha A, Shah JP, Kraus DH, Wong RJ, Lee NY

  • Int J Radiat Oncol Biol Phys.
    2009 Mar 15;73(4):1096-103.

March 23, 2009

Fig 5B. Immunofluorescence by confocal microscopy on A and G0 cells using p27 (panels 1) or phosphoY89p27 (panels 2) antibodies.

Fig 5B. Immunofluorescence by confocal microscopy on A and G0 cells using p27 (panels 1) or phosphoY89p27 (panels 2) antibodies.

  • Ray A, James MK, Larochelle S, Fisher RP, Blain SW

  • Mol Cell Biol.
    2009 Feb;29(4):986-99.

March 20, 2009

Fig 1. Radiographic response at tumor core but overall size of lesion measured as stable disease (SD) by RECIST criteria.

Fig 1. Radiographic response at tumor core but overall size of lesion measured as stable disease (SD) by RECIST criteria.

  • Kreisl TN, Lassman AB, Mischel PS, Rosen N, Scher HI, Teruya-Feldstein J, Shaffer D, Lis E, Abrey LE

  • J Neurooncol.
    2009 Feb 1;19(3):922-5.

March 18, 2009

Fig 6. Actively metabolizing tumor with pre- and posttreatment uptake of 18F-FDHT, an androgen ligand radiotracer, in multiple lumbar vertebrae before (left) and after (right) treatment with Medivation, a high-affinity androgen receptor being studied under approved protocol at MSKCC.

Fig 6. Actively metabolizing tumor with pre- and posttreatment uptake of 18F-FDHT, an androgen ligand radiotracer, in multiple lumbar vertebrae before (left) and after (right) treatment with Medivation, a high-affinity androgen receptor being studied under approved protocol at MSKCC.

  • Zhao B, Schwartz LH, Larson SM

  • J Nucl Med.
    2009 Feb;50(2):239-49.

March 17, 2009

Fig 2. X-ray crystallographic structure of 12: CCDC 710680.

Fig 2. X-ray crystallographic structure of 12: CCDC 710680.

  • Yang G, Yin YI, Chun J, Shelton CC, Ouerfelli O, Li YM

  • Bioorg Med Chem Lett.
    2009 Feb 1;19(3):922-5.

March 13, 2009

Fig 1. Phosphorylation (activation) of ERM proteins is dynamically regulated during metastatic progression.

Fig 1. Phosphorylation (activation) of ERM proteins is dynamically regulated during metastatic progression.

  • Ren L, Hong SH, Cassavaugh J, Osborne T, Chou AJ, Kim SY, Gorlick R, Hewitt SM, Khanna C

  • Oncogene.
    2009 Feb 12;28(6):792-802.

March 12, 2009

Fig 1c. Prostate specific overexpression of ERG does not induce high grade prostatic intra-epithelial neoplasia.

Fig 1c. Prostate specific overexpression of ERG does not induce high grade prostatic intra-epithelial neoplasia.

  • Carver BS, Tran J, Chen Z, Carracedo-Perez A, Alimonti A, Nardella C, Gopalan A, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP

  • Nature.
    2009 Feb 12;457(7231):E1; discussion E2-3.

March 11, 2009

Fig 1. Coronal slice representative of isodose distribution of typical treatment plan delivered for thyroid cancer for 69-year-old man who had presented with recurrent medullary thyroid cancer.

Fig 1. Coronal slice representative of isodose distribution of typical treatment plan delivered for thyroid cancer for 69-year-old man who had presented with recurrent medullary thyroid cancer.

  • Terezakis SA, Lee KS, Ghossein RA, Rivera M, Tuttle RM, Wolden SL, Zelefsky MJ, Wong RJ, Patel SG, Pfister DG, Shaha AR, Lee NY

  • Int J Radiat Oncol Biol Phys.
    2009 Mar 1;73(3):795-801.

March 10, 2009

Fig 1. Canonical miRNA and mirtron pathways in Drosophila.

Fig 1. Canonical miRNA and mirtron pathways in Drosophila.

  • Martin R, Smibert P, Yalcin A, Tyler DM, Schäfer U, Tuschl T, Lai EC

  • Mol Cell Biol.
    2009 Feb;29(3):861-70.

March 9, 2009

Fig 1. Both hindbrain and midbrain floor plate are dependent on Shh for floor plate induction.

Fig 1. Both hindbrain and midbrain floor plate are dependent on Shh for floor plate induction.

  • Fasano CA, Studer L

  • Nat Neurosci.
    2009 Feb;12(2):107-8.

March 6, 2009

Fig 1. Autocrine IL-6 Mediates gp130/JAK/STAT3 Signaling and Promotes Tumorigenesis.

Fig 1. Autocrine IL-6 Mediates gp130/JAK/STAT3 Signaling and Promotes Tumorigenesis.

  • Bromberg J, Wang TC

  • Cancer Cell.
    2009 Feb 3;15(2):79-80.

March 5, 2009

Fig 2c. Parental MDA-MB-231 cells and lung metastatic LM2 cells expressing miR-126, miR-335 or miR-206 were seeded onto glass slides. Cells were stained with the actin marker phalloidin and confocal images were obtained.

Fig 2c. Parental MDA-MB-231 cells and lung metastatic LM2 cells expressing miR-126, miR-335 or miR-206 were seeded onto glass slides. Cells were stained with the actin marker phalloidin and confocal images were obtained.

  • Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J

  • Nature.
    2008 Jan 10;451(7175):147-52.

March 4, 2009

Fig 10. LysoTracker Red stains lysosomes and can be used to monitor autophagy in Drosophila melanogaster.

Fig 10. LysoTracker Red stains lysosomes and can be used to monitor autophagy in Drosophila melanogaster.

  • Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA Jr, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Hřyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL

  • Autophagy.
    2008 Feb 16;4(2):151-75.

March 3, 2009

Fig 4. Graphic illustrating the roles of 8 genes implicated in the present study in lithium-sensitive signaling pathways.

Fig 4. Graphic illustrating the roles of 8 genes implicated in the present study in lithium-sensitive signaling pathways.

  • Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nöthen MM, Georgi A, Schumacher J, Schwarz M, Abou Jamra R, Höfels S, Propping P, Satagopan J, Detera-Wadleigh SD, Hardy J, McMahon FJ

  • Mol Psychiatry.
    2008 Feb;13(2):197-207.

March 2, 2009

CA: A Cancer Journal for Clinicians is a peer-reviewed journal of the American Cancer Society providing cancer care professionals with up-to-date information on all aspects of cancer diagnosis, treatment, and prevention.

CA: A Cancer Journal for Clinicians is a peer-reviewed journal of the American Cancer Society providing cancer care professionals with up-to-date information on all aspects of cancer diagnosis, treatment, and prevention.

  • Levin B, Lieberman DA, McFarland B, Andrews KS, Brooks D, Bond J, Dash C, Giardiello FM, Glick S, Johnson D, Johnson CD, Levin TR, Pickhardt PJ, Rex DK, Smith RA, Thorson A, Winawer SJ, American Cancer Society Colorectal Cancer Advisory Group, US Multi-Society Task Force, American College of Radiology Colon Cancer Committee

  • CA Cancer J Clin.
    2008 May-Jun;58(3):130-60.

February 27, 2009

As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology.

As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology.

  • Levin B, Lieberman DA, McFarland B, Andrews KS, Brooks D, Bond J, Dash C, Giardiello FM, Glick S, Johnson D, Johnson CD, Levin TR, Pickhardt PJ, Rex DK, Smith RA, Thorson A, Winawer SJ; American Cancer Society Colorectal Cancer Advisory Group; US Multi-Society Task Force; American College of Radiology Colon Cancer Committeep

  • Gastroenterology.
    2008 May;134(5):1570-95.

February 26, 2009

Fig 5b. FISH analysis of the TMPRSS2 and ERG loci in 2+Edel cancers.

Fig 5b. FISH analysis of the TMPRSS2 and ERG loci in 2+Edel cancers.

  • Attard G, Clark J, Ambroisine L, Fisher G, Kovacs G, Flohr P, Berney D, Foster CS, Fletcher A, Gerald WL, Moller H, Reuter V, De Bono JS, Scardino P, Cuzick J, Cooper CS; Transatlantic Prostate Group

  • Oncogene.
    2008 Jan 10;27(3):253-63.

February 25, 2009

Fig 1D. Chromosome analysis of CAPAN1 cells exposed to MMC for 24 h. Arrows indicate chromatid breaks, triradials and other chromosome aberrations.

Fig 1D. Chromosome analysis of CAPAN1 cells exposed to MMC for 24 h. Arrows indicate chromatid breaks, triradials and other chromosome aberrations.

  • Edwards SL, Brough R, Lord CJ, Natrajan R, Vatcheva R, Levine DA, Boyd J, Reis-Filho JS, Ashworth A

  • Nature.
    2008 Feb 28;451(7182):1111-5.

February 24, 2009

Blood celebrates the 50th anniversary of the American Society of Hematology. The Blood cover has evolved over the past 50 years, as shown. Illustration by A. Y. Chen.

Blood celebrates the 50th anniversary of the American Society of Hematology. The Blood cover has evolved over the past 50 years, as shown. Illustration by A. Y. Chen.

  • Rizzo JD, Somerfield MR, Hagerty KL, Seidenfeld J, Bohlius J, Bennett CL, Cella DF, Djulbegovic B, Goode MJ, Jakubowski AA, Rarick MU, Regan DH, Lichtin AE

  • Blood.
    2008 Jan 1;111(1):25-41.

February 23, 2009

Fig 2. Progression-free survival (intent to treat population).

Fig 2. Progression-free survival (intent to treat population).

  • Saltz LB, Clarke S, Díaz-Rubio E, Scheithauer W, Figer A, Wong R, Koski S, Lichinitser M, Yang TS, Rivera F, Couture F, Sirzén F, Cassidy J

  • J Clin Oncol.
    2008 Apr 20;26(12):2013-9.

February 20, 2009

Fig 1b. Ribbon diagram of the structure of the Aquifex aeolicus Piwi protein, showing its bilobed architecture.

Fig 1b. Ribbon diagram of the structure of the Aquifex aeolicus Piwi protein, showing its bilobed architecture.

  • Farazi TA, Juranek SA, Tuschl T

  • Development.
    2008 Apr;135(7):1201-14.

February 19, 2009

Fig 1F.  PGCs, HSCs, and blood progenitors in the zebrafish at not, vert, similar 24–28 hours postfertilization.

Fig 1F. PGCs, HSCs, and blood progenitors in the zebrafish at not, vert, similar 24–28 hours postfertilization.

  • Laird DJ, von Andrian UH, Wagers AJ

  • Cell.
    2008 Feb 22;132(4):612-30.

February 18, 2009

Fig 1. Prostate cancer clinical-states model, a framework for patient management and drug development.

Fig 1. Prostate cancer clinical-states model, a framework for patient management and drug development.

  • Scher HI, Halabi S, Tannock I, Morris M, Sternberg CN, Carducci MA, Eisenberger MA, Higano C, Bubley GJ, Dreicer R, Petrylak D, Kantoff P, Basch E, Kelly WK, Figg WD, Small EJ, Beer TM, Wilding G, Martin A, Hussain M; Prostate Cancer Clinical Trials Working Group

  • J Clin Oncol.
    2008 Mar 1;26(7):1148-59.

February 17, 2009

Fig 4c. CD133 is expressed in differentiated epithelium of normal human colon.

Fig 4c. CD133 is expressed in differentiated epithelium of normal human colon.

  • Shmelkov SV, Butler JM, Hooper AT, Hormigo A, Kushner J, Milde T, St Clair R, Baljevic M, White I, Jin DK, Chadburn A, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, D'Angelica M, Kemeny N, Lyden D, Rafii S

  • J Clin Invest.
    2008 Jun;118(6):2111-20.

February 16, 2009

Fig 1b. The steric role of PSA at the cell surface. A schematic representation of molecular interactions during membrane–membrane contact.

Fig 1b. The steric role of PSA at the cell surface. A schematic representation of molecular interactions during membrane–membrane contact.

  • Rutishauser U

  • Nat Rev Neurosci.
    2008 Jan;9(1):26-35.

February 13, 2009

Fig 2. Mean monthly untransfused hemoglobin levels in TI responders and nonresponders (N = 214).

Fig 2. Mean monthly untransfused hemoglobin levels in TI responders and nonresponders (N = 214).

  • Raza A, Reeves JA, Feldman EJ, Dewald GW, Bennett JM, Deeg HJ, Dreisbach L, Schiffer CA, Stone RM, Greenberg PL, Curtin PT, Klimek VM, Shammo JM, Thomas D, Knight RD, Schmidt M, Wride K, Zeldis JB, List AF

  • Blood.
    2008 Jan 1;111(1):86-93.

February 12, 2009

Figure 2a. IL-10 controls T cell tolerance at the interface between the innate and the adaptive immune systems.

Figure 2a. IL-10 controls T cell tolerance at the interface between the innate and the adaptive immune systems.

  • Li MO, Flavell RA

  • Immunity.
    2008 Apr;28(4):468-76.

February 11, 2009

Fig 1a. Progression-free survival.

Fig 1a. Progression-free survival.

  • Miller VA, Riely GJ, Zakowski MF, Li AR, Patel JD, Heelan RT, Kris MG, Sandler AB, Carbone DP, Tsao A, Herbst RS, Heller G, Ladanyi M, Pao W, Johnson DH

  • J Clin Oncol.
    2008 Mar 20;26(9):1472-8.

February 10, 2009

Fig 1.  PET Scans Obtained before T-Cell Infusion and 2 Months after Infusion.

Fig 1. PET Scans Obtained before T-Cell Infusion and 2 Months after Infusion.

  • Hunder NN, Wallen H, Cao J, Hendricks DW, Reilly JZ, Rodmyre R, Jungbluth A, Gnjatic S, Thompson JA, Yee C

  • N Engl J Med.
    2008 Jun 19;358(25):2698-703.

February 9, 2009

Fig 4. Landmark analysis of overall survival according to the cytogenetic response at 12 months.

Fig 4. Landmark analysis of overall survival according to the cytogenetic response at 12 months.

  • Hochhaus A, Druker B, Sawyers C, Guilhot F, Schiffer CA, Cortes J, Niederwieser DW, Gambacorti-Passerini C, Stone RM, Goldman J, Fischer T, O'Brien SG, Reiffers JJ, Mone M, Krahnke T, Talpaz M, Kantarjian HM

  • Blood.
    2008 Feb 1;111(3):1039-43.

February 6, 2009

Fig 3a. hpRNAs generate regulatory RNAs that can repress endogenous targets.

Fig 3a. hpRNAs generate regulatory RNAs that can repress endogenous targets.

  • Okamura K, Chung WJ, Ruby JG, Guo H, Bartel DP, Lai EC

  • Nature.
    2008 Jun 5;453(7196):803-6.

February 5, 2009

Fig 4E. Wild-type thorax.

Fig 4E. Wild-type thorax.

  • Tyler DM, Okamura K, Chung WJ, Hagen JW, Berezikov E, Hannon GJ, Lai EC

  • Genes Dev.
    2008 Jan 1;22(1):26-36.

February 4, 2009

Fig 4D. Triple immunofluorescent merged images of human medulloblastoma samples showing existence of stem cell niches around blood vessels similar to mouse tumors.

Fig 4D. Triple immunofluorescent merged images of human medulloblastoma samples showing existence of stem cell niches around blood vessels similar to mouse tumors.

  • Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova-Todorova K, Holland EC

  • Genes Dev.
    2008 Feb 15;22(4):436-48.

February 3, 2009

Fig 1E. hESC-derived neural rosettes adopt polarized neuroepithelial structures of anterior CNS fate; day 16 rosettes colocalized with N-cad.

Fig 1E. hESC-derived neural rosettes adopt polarized neuroepithelial structures of anterior CNS fate; day 16 rosettes colocalized with N-cad.

  • Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L

  • Genes Dev.
    2008 May 1;22(9):1257.

February 2, 2009

Fig 1. Cumulative Breast Cancer Incidence in Relatives of Probands.

Fig 1. Cumulative Breast Cancer Incidence in Relatives of Probands.

  • Begg CB, Haile RW, Borg A, Malone KE, Concannon P, Thomas DC, Langholz B, Bernstein L, Olsen JH, Lynch CF, Anton-Culver H, Capanu M, Liang X, Hummer AJ, Sima C, Bernstein JL

  • JAMA.
    2008 Jan 9;299(2):194-201.

January 30, 2009

Fig 2ab. Examples of baseline and follow-up contours for participant without previous head-and-neck rotation.

Fig 2ab. Examples of baseline and follow-up contours for participant without previous head-and-neck rotation.
    Bekelman JE, Wolden S, Lee N

  • Int J Radiat Oncol Biol Phys.
    2009 Feb 1;73(2):416-23.

January 29, 2009

Fig 1b. Crystal structure of T. thermophilus Ago bound to 5'-phosphorylated 21-nucleotide guide DNA and 20-nucleotide target RNA.

Fig 1b. Crystal structure of T. thermophilus Ago bound to 5'-phosphorylated 21-nucleotide guide DNA and 20-nucleotide target RNA.
    Wang Y, Juranek S, Li H, Sheng G, Tuschl T, Patel DJ

  • Nature.
    2008 Dec 18;456(7224):921-6.

January 28, 2009

Fig 4c. Mdc1 recruitment is defective in WSTF-deficient cells. Immunofluorescent staining experiments were performed with anti-Mdc1 antibodies on control or WSTF RNAi cells, 8 h after 10 Gy of ionizing radiation treatment. DAPI, 4,6-diamidino-2-phenylindole.

Fig 4c. Mdc1 recruitment is defective in WSTF-deficient cells. Immunofluorescent staining experiments were performed with anti-Mdc1 antibodies on control or WSTF RNAi cells, 8 h after 10 Gy of ionizing radiation treatment. DAPI, 4,6-diamidino-2-phenylindole.
    Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD

  • Nature.
    2009 Jan 1;457(7225):57-62.

January 27, 2009

Fig 1c. In <i>Kit<sup>Y567F/Y567F</sup></i> mice, high-dose 5-fluorouracil (5-FU) administration leads to fatal anemia.

Fig 1c. In KitY567F/Y567F mice, high-dose 5-fluorouracil (5-FU) administration leads to fatal anemia.
    Agosti V, Karur V, Sathyanarayana P, Besmer P, Wojchowski DM

  • Exp Hematol.
    2009 Feb;37(2):159-71.

January 26, 2009

Fig 1a. Venous phase magnetic resonance (MR) image of a recently ruptured liver cell adenoma encompassing nearly 50% of the right hemi liver and extending into the left hemi liver.

Fig 1a. Venous phase magnetic resonance (MR) image of a recently ruptured liver cell adenoma encompassing nearly 50% of the right hemi liver and extending into the left hemi liver.
    Deneve JL, Pawlik TM, Cunningham S, Clary B, Reddy S, Scoggins CR, Martin RC, D'Angelica M, Staley CA, Choti MA, Jarnagin WR, Schulick RD, Kooby DA

  • Ann Surg Oncol.
    2009 Jan 8.

January 23, 2009

Fig 2. Kaplan-Meier probability of freedom from recurrence following salvage prostatectomy by biopsy Gleason score.

Fig 2. Kaplan-Meier probability of freedom from recurrence following salvage prostatectomy by biopsy Gleason score.
    Paparela P, Cronina AM, Savage C, Scardino PT, Eastham JA

  • Eur Urol.
    2009 Feb;55(2):404-411.

January 22, 2009

Fig 1. Unsupervised cluster analysis of chondrosarcoma (red), chordoma (green) and soft tissue sarcoma (blue).

Fig 1. Unsupervised cluster analysis of chondrosarcoma (red), chordoma (green) and soft tissue sarcoma (blue).
    Paparela P, Cronina AM, Savage C, Scardino PT, Eastham JA

  • Cancer Immunol Immunother.
    2009 Mar;58(3):339-49.

January 21, 2009

Fig 1. Hsp90 inhibitors containing the 8-arylmethyl-9H-purin-6-amine core.

Fig 1. Hsp90 inhibitors containing the 8-arylmethyl-9H-purin-6-amine core.
    Tao H, Kang Y, Taldone T, Chiosis G

  • Bioorg Med Chem Lett.
    2009 Jan 15;19(2):415-7.

January 19, 2009

Fig 6. The DDB2 Surface and Hairpin Are Important Structural Features of the Damage Recognition Process.

Fig 6. The DDB2 Surface and Hairpin Are Important Structural Features of the Damage Recognition Process.
    Scrima A, Konícková R, Czyzewski BK, Kawasaki Y, Jeffrey PD, Groisman R, Nakatani Y, Iwai S, Pavletich NP, Thomä NH

  • Cell.
    2008 Dec 26;135(7):1213-23.

January 16, 2009

Fig 1b. Colony assays documenting the effect of shRNAs targeting MYCN on the growth of IMR-32 and SH-EP cells. Cells were infected with the indicated retroviruses and grown in the presence of puromycin for 6 days.

Fig 1b. Colony assays documenting the effect of shRNAs targeting MYCN on the growth of IMR-32 and SH-EP cells. Cells were infected with the indicated retroviruses and grown in the presence of puromycin for 6 days.
    Otto T, Horn S, Brockmann M, Eilers U, Schüttrumpf L, Popov N, Kenney AM, Schulte JH, Beijersbergen R, Christiansen H, Berwanger B, Eilers M

  • Cancer Cell.
    2009 Jan 6;15(1):67-78.

January 15, 2009

Fig 3b. A view of the most untwisted structure in G6G7*.

Fig 3b. A view of the most untwisted structure in G6G7*.
    Cai Y, Patel DJ, Geacintov NE, Broyde S

  • J Mol Biol.
    2009 Jan 9;385(1):30-44.

January 14, 2009

Fig 4d. gamma-H2AX foci generation in HSCs following irradiation.

Fig 4d. γ-H2AX foci generation in HSCs following irradiation.
    Liu Y, Elf SE, Miyata Y, Sashida G, Liu Y, Huang G, Di Giandomenico S, Lee JM, Deblasio A, Menendez S, Antipin J, Reva B, Koff A, Nimer SD

  • Cell Stem Cell.
    2009 Jan 9;4(1):37-48.

January 13, 2009

Fig 12a. Intraductal papillary mucinous neoplasm (IPMN) with extension of the intraductal component into small duct branches in the fibrotic stroma, mimicking invasive carcinoma.

Fig 12a. Intraductal papillary mucinous neoplasm (IPMN) with extension of the intraductal component into small duct branches in the fibrotic stroma, mimicking invasive carcinoma.
    Katabi N, Klimstra D

  • J Clin Pathol.
    2008 Dec;61(12):1303-13.

January 12, 2009

Fig 4. Left lower lobe, superior segment, again showing intraaalveolar macrophages (hematoxylin-eosin, original × 40).

Fig 4. Left lower lobe, superior segment, again showing intraaalveolar macrophages (hematoxylin-eosin, original × 40).
    Chawla M, Boroumand N, Alexandrou C, Stover D

  • Chest.
    2008 Dec;134(6):1320-4.

January 9, 2009

Fig 2a. A pedunculated polypoid lesion emanating inferiorly from the posterior wall filled the entire nasopharynx and blocked the posterior choanae bilaterally. The lesion was excised.

Fig 2a. A pedunculated polypoid lesion emanating inferiorly from the posterior wall filled the entire nasopharynx and blocked the posterior choanae bilaterally. The lesion was excised.
    Yoshida A, Borkar S, Singh B, Ghossein RA, Schöder H

  • J Clin Oncol.
    2008 Dec 10;26(35):5817-9.

January 8, 2009

Fig 1a. Representative FcRIIB-staining of a primary skin melanoma.

Fig 1a. Representative FcRIIB-staining of a primary skin melanoma.
    Cassard L, Cohen-Solal JF, Fournier EM, Camilleri-Broët S, Spatz A, Chouaďb S, Badoual C, Varin A, Fisson S, Duvillard P, Boix C, Loncar SM, Sastre-Garau X, Houghton AN, Avril MF, Gresser I, Fridman WH, Sautčs-Fridman C

  • Int J Cancer.
    2008 Dec 15;123(12):2832-9.

January 7, 2009

Fig 5a. Venn diagram illustrating the regulators involved in controlling hypoxically induced (oxygen-suppressed) genes in HAP1 and delta-hap1 cells, and heme-suppressed genes.

Fig 5a. Venn diagram illustrating the regulators involved in controlling hypoxically induced (oxygen-suppressed) genes in HAP1 and delta-hap1 cells, and heme-suppressed genes.
    Kundaje A, Xin X, Lan C, Lianoglou S, Zhou M, Zhang L, Leslie C

  • PLoS Comput Biol.
    2008 Nov;4(11):e1000224.

January 6, 2009

Fig 2b. Collagen gel treatment and decreased TGF-beta1 expression are associated with decreased scarring and fibrosis.

Fig 2b. Collagen gel treatment and decreased TGF-beta1 expression are associated with decreased scarring and fibrosis.
    Clavin NW, Avraham T, Fernandez J, Daluvoy SV, Soares MA, Chaudhry A, Mehrara BJ

  • Am J Physiol Heart Circ Physiol.
    2008 Nov;295(5):H2113-27.

January 5, 2009

Fig 4a. Knockdown of SMAD6 induces cell arrest and increases apoptosis in H1299 cells.

Fig 4a. Knockdown of SMAD6 induces cell arrest and increases apoptosis in H1299 cells.
    Jeon HS, Dracheva T, Yang SH, Meerzaman D, Fukuoka J, Shakoori A, Shilo K, Travis WD, Jen J

  • Cancer Res.
    2008 Dec 1;68(23):9686-92.

January 2, 2009

Fig 3d. Electrostatic surface representation of the protein-RNA interface highlighting intermolecular contacts between G2-C3-U4 segment and MBNL1 ZnF4.

Fig 3d. Electrostatic surface representation of the protein-RNA interface highlighting intermolecular contacts between G2-C3-U4 segment and MBNL1 ZnF4.
    Teplova M, Patel DJ

  • Nat Struct Mol Biol.
    2008 Dec;15(12):1343-51.

Content editor, Sarah Jewell
Last revised: April 1, 2009 3:20 PMST
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