Home Today's science sparks archives Today's science sparks archives - January to March 2007
Today's science sparks archives - January to March 2007
This page contains images and links to articles previously featured.
March 31, 2008
Fig 5. Quenching effect of EGCG on BSA fluorescence intensity.
Xiao J, Chen X, Zhang L, Talbot SG, Li GC, Xu M J Agric Food Chem.
March 28, 2008
4D. Triple immunofluorescent merged images (pS6RP [green]/CD31 [red]/DAPI [blue], CD31 [red]]/nestin [green]/DAPI [blue], nestin [green]/pS6RP [red]/DAPI [blue], and nestin [green]/notch receptor [red]/DAPI [blue]) of human medulloblastoma samples showing existence of stem cell niches around blood vessels similar to mouse tumors (n = 2 frozen and 13 paraffin sections, total 15).
Hambardzumyan D, Becher OJ, Rosenblum MK, Pandolfi PP, Manova-Todorova K, Holland EC Genes Dev.
March 27, 2008
Platelets direct site-specific recruitment of bone marrow–derived progenitor cells to sites of vasculogenesis.
Rafii DC, Psaila B, Butler J, Jin DK, Lyden D Arterioscler Thromb Vasc Biol.
March 26, 2008
Fig 1. Abdominopelvic regions. (A) Upper abdomen cephalad to the greater omentum. (B) Mid-abdomen. (C) Pelvis.
Zivanovic O, Eisenhauer EL, Zhou Q, Iasonos A, Sabbatini P, Sonoda Y, Abu-Rustum NR, Barakat RR, Chi DS Gynecol Oncol.
March 25, 2008
Fig 3. Inducer binding to the lac repressor.
Saiz L, Vilar JM Nucleic Acids Res.
March 24, 2008
Fig 2A. Benign splenic tissue in aspiration biopsy.
Friedlander MA, Wei XJ, Iyengar P, Moreira AL Diagn Cytopathol.
March 21, 2008
Fig 4A. Determination of Akt activation in tumor tissue during mTOR inhibitor therapy.
Cloughesy TF, Yoshimoto K, Nghiemphu P, Brown K, Dang J, Zhu S, Hsueh T, Chen Y, Wang W, Youngkin D, Liau L, Martin N, Becker D, Bergsneider M, Lai A, Green R, Oglesby T, Koleto M, Trent J, Horvath S, Mischel PS, Mellinghoff IK, Sawyers CL PLoS Med.
March 20, 2008
Fig 1. General architecture of the helicase–primase complex.
Marians KJ Nat Struct Mol Biol.
March 19, 2008
Fig 1. Diagram illustrating the technique used to sew in the PTFE tube grafts.
Paran TS, Corbally MT, Gross-Rom E, Rutigliano DN, Kayton ML, La Quaglia MP J Pediatr Surg.
March 18, 2008
Fig 2B. Anaplastic/pleomorphic giant cells demonstrating strong nuclear Pax8 expression.
Nonaka D, Tang Y, Chiriboga L, Rivera M, Ghossein R Mod Pathol.
March 17, 2008
Fig 1A. Box-and-whisker plots of (a) mean ADC (in square millimeters per second) and (b) mean MET in prostate cancer (PCa) and benign PZ ROIs from 38 patients.
Mazaheri Y, Shukla-Dave A, Hricak H, Fine SW, Zhang J, Inurrigarro G, Moskowitz CS, Ishill NM, Reuter VE, Touijer K, Zakian KL, Koutcher JA Radiology.
March 14, 2008
Fig 7F. Reduced numbers of RGCs and RGC axons and cell death in EomesΔflox/Δflox mice.
Mao CA, Kiyama T, Pan P, Furuta Y, Hadjantonakis AK, Klein WH Development.
March 13, 2008
Fig 2. Schematic model of epigenetic changes in the onset of cancer.
Rajasekhar VK, Begemann M Stem Cells.
March 12, 2008
Fig 2A. Use of Caco-2 cells to monitor the bidirectional intestinal transport of phytochemicals.
Barnes S, Birt DF, Cassileth BR, Cefalu WT, Chilton FH, Farnsworth NR, Raskin I, van Breemen RB, Weaver CM Am J Clin Nutr.
March 11, 2008
Fig 1. Steps in TGF-β:Receptor Complex Formation.
Joan Massagué Mol Cell.
March 10, 2008
Fig 4. Histogram of nomogram-predicted freedom from recurrence.
Weiser MR, Landmann RG, Kattan MW, Gonen M, Shia J, Chou J, Paty PB, Guillem JG, Temple LK, Schrag D, Saltz LB, Wong WD J Clin Oncol.
March 7, 2008
Fig 4A. Structure of the 10
S -(+)-
trans-anti -B[a]P-N²-dG adduct n polymerase BF (PDB ID:1XC9).
Broyde S, Wang L, Zhang L, Rechkoblit O, Geacintov NE, Patel DJ Chem Res Toxicol.
March 6, 2008
Fig 6A. ARA70β is not expressed in benign prostate tissue by immunohistochemistry using an ARA70β isoform-specific antibody.
Peng Y, Li CX, Chen F, Wang Z, Ligr M, Melamed J, Wei J, Gerald W, Pagano M, Garabedian MJ, Lee P Am J Pathol.
March 5, 2008
Fig 6A. Post-operative radiograph showing the allograft prosthetic composite reconstruction.
Schwab JH, Healey JH, Athanasian EA J Bone Joint Surg Br.
March 4, 2008
Fig 2. Diagnostic accuracy (AUC) of a “base” model to predict biopsy outcome including age and pre-treatment total PSA and of the same model supplemented by free PSA subforms and various plasminogen activator receptor (uPAR) isoforms (full model) among 355 referral patients.
Steuber T, O'Brien MF, Lilja H Eur Urol.
March 3, 2008
Fig 1E. hESC-derived neural rosettes adopt polarized neuroepithelial structures of anterior CNS fate; day 16 rosettes colocalized with N-cad.
Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L Genes Dev.
February 29, 2008
Fig 1. Primary melanoma with regression.
Morris KT, Busam KJ, Bero S, Patel A, Brady MS Ann Surg Oncol.
February 28, 2008
Fig 1A. Multiple pencil beams delivered by the Cyberknife converging at the target to deliver the high single fraction radiation dose.
Cupp JS, Koong AC, Fisher GA, Norton JA, Goodman KA Clin Oncol (R Coll Radiol).
February 27, 2008
Fig 1. Schematic representation of tumorigenesis in view of the CSC model.
Rajasekhar VK, Dalerba P, Passegué E, Lagasse E, Najbauer J Stem Cells.
February 26, 2008
FFig 3. In situ subungual melanoma arising on the thumb of a 65-year-old woman.
Cohen T, Busam KJ, Patel A, Brady MS Am J Surg.
February 25, 2008
Fig 3E. 3D view of the SPECT/CT data shown in Figure 2 (monocytes transferred into ApoE-/- mouse).
Kircher MF, Grimm J, Swirski FK, Libby P, Gerszten RE, Allport JR, Weissleder R Circulation.
February 22, 2008
Fig 4D. IHC staining of tumor sections for Id1 after treatment with Id1-AO or Id1-PCAO.
Henke E, Perk J, Vider J, de Candia P, Chin Y, Solit DB, Ponomarev V, Cartegni L, Manova K, Rosen N, Benezra R Nat Biotechnol.
February 21, 2008
Fig 2. Pneumatosis Intestinalis.
Asmis TR, Chung KY, Teitcher JB, Kelsen DP, Shah MA Invest New Drugs.
February 20, 2008
Fig 4E. Wild-type thorax.
Tyler DM, Okamura K, Chung WJ, Hagen JW, Berezikov E, Hannon GJ, Lai EC Genes Dev.
February 19, 2008
Fig 1. The choice of bone graft depends largely on exposure. The shape of the inner cortex of both the frontal bone plate and the iliac crest is ideal to reproduce the contour of the orbital floor and the shape of the orbital rim.
Chen CM, Cordeiro PG Plast Reconstr Surg.
February 18, 2008
Fig 2C. Parental MDA-MB-231 cells and lung metastatic LM2 cells expressing miR-126, miR-335 or miR-206 were seeded onto glass slides.
Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J Nature.
February 15, 2008
Fig 1. Golden triangle of T cell activation.
Feinerman O, Germain RN, Altan-Bonnet G Mol Immunol.
February 14, 2008
Fig 3. Histologic sectioning: central row contains serial sections of tumor debulking; serial sections of peripheral margins are arranged clockwise with suture orientation; deep and outer surgical margins are inked black.
Hazan C, Dusza SW, Delgado R, Busam KJ, Halpern AC, Nehal KS J Am Acad Dermatol.
February 13, 2008
Fig 5. Example of a Monte Carlo simulation of MIR estimation.
Ward BD, Mazaheri Y J Neurosci Methods.
February 12, 2008
Fig 3. The platysma muscle is incised and cutaneous flaps are developed in the subplatysmal plane.
Gil Z, Patel SG Surg Oncol Clin N Am.
February 11, 2008
Fig 1. PET/CT imaging of hypoxia.
Grimm J, Hricak H Curr Opin Urol.
February 8, 2008
Fig 5. Schematic representation of PGE2 signaling within fibroblasts and potential sites of defects conferring resistance to PGE2 in usual interstitial pneumonia (UIP) fibroblasts.
Huang SK, Wettlaufer SH, Hogaboam CM, Flaherty KR, Martinez FJ, Myers JL, Colby TV, Travis WD, Toews GB, Peters-Golden M Am J Respir Crit Care Med.
February 7, 2008
Fig 1B. A schematic representation of molecular interactions during membrane–membrane contact.
Urs Rutishauser Nat Rev Neurosci.
February 6, 2008
Fig 2. An example of endometrial carcinoma with apparent peritumoral lymphocytes.
Shia J, Black D, Hummer AJ, Boyd J, Soslow RA Hum Pathol.
February 5, 2008
Fig 1E. Schematic showing quantification of GFP expression in individual muscles from Table 1.
Beckett K, Rochlin KM, Duan H, Nguyen HT, Baylies MK Gene Expr Patterns.
February 4, 2008
Fig 1. Integrating core communication concepts.
Brown RF, Bylund CL Acad Med.
February 1, 2008
Figure1B. Generation of isosurface image profiles from phantom study.
Wang L, Mazaheri Y, Zhang J, Ishill NM, Kuroiwa K, Hricak H Radiology.
January 31, 2008
Figure 3D. GRO-α and MIG detected in colonic tissue by immunohistochemistry.
Egesten A, Eliasson M, Olin AI, Erjefält JS, Bjartell A, Sangfelt P, Carlson M Int J Colorectal Dis.
January 30, 2008
Figure 1. Model of adjustment to cancer.
Lethborg C, Aranda S, Cox S, Kissane D Palliat Support Care.
January 29, 2008
Figure 3E. Structure of the Fbw7 F-box bound to phosphorylated cyclin E C-terminal degron [31].
Capili AD, Lima CD Curr Opin Struct Biol.
January 28, 2008
Figure 1C. In MEDUSA, every differentially expressed target gene–experiment example is a separate training example, represented by sequence data (the gene's promoter sequence) and regulation expression data (the expression states of regulators in the experiment).
Kundaje A, Lianoglou S, Li X, Quigley D, Arias M, Wiggins CH, Zhang L, Leslie C Ann N Y Acad Sci.
January 25, 2008
Figure 2. Classification of A. fumigatus mutants based on phenotypic characteristics that favor fungal growth or clearance in immunocompromised hosts.
Hohl TM, Feldmesser M Eukaryot Cell.
January 24, 2008
Figure 1A. Cerebral angiographic views of left middle cerebral artery (MCA) demonstrate distal M1 and M2 occlusions; Antero-posterior view.
Navi BB, DeAngelis LM, Segal AZ J Neurooncol.
January 23, 2008
Figure 3E. Wild-type adult fly.
Silver SJ, Hagen JW, Okamura K, Perrimon N, Lai EC Proc Natl Acad Sci U S A.
January 22, 2008
Figure 1E. Histologic appearance and immunoprofile of AFH.
Antonescu CR, Dal Cin P, Nafa K, Teot LA, Surti U, Fletcher CD, Ladanyi M Genes Chromosomes Cancer.
January 21, 2008
Figure 2A. The butterfly proton transmit/receive coil constructed for breast MRI/MRSI experiments.
He Q, Shkarin P, Hooley RJ, Lannin DR, Weinreb JC, Bossuyt VI Magn Reson Med.
January 18, 2008
Figure 1A. Expression and localization of NPMc+ vs NPM in transduced primary MEFs.
Cheng K, Grisendi S, Clohessy JG, Majid S, Bernardi R, Sportoletti P, Pandolfi PP Oncogene.
January 17, 2008
Figure 2. Comparison of SNP bins derived from pair-wise measurements of linkage disequilibrium using LDSelect-Comp.
Pereira LH, Pineda MA, Rowe WH, Fonseca LR, Greene MH, Offit K, Ellis NA, Zhang J, Collins A, Struewing JP BMC Genet.
January 16, 2008
Figure 5D. Close-up view showing Sec23 contacts at the Sar1 active site.
Bi X, Mancias JD, Goldberg J Dev Cell.
January 15, 2008
Figure 1. Nine benign patterns representing "beauty."
Marghoob AA, Korzenko AJ, Changchien L, Scope A, Braun RP, Rabinovitz H Dermatol Surg.
January 14, 2008
Figure 1. Cavity depth Connolly surface rendering of 5 docked into Abl kinase domain.
Veach DR, Namavari M, Pillarsetty N, Santos EB, Beresten-Kochetkov T, Lambek C, Punzalan BJ, Antczak C, Smith-Jones PM, Djaballah H, Clarkson B, Larson SM J Med Chem.
January 11, 2008
Figure 1. Hypothetical models of drug tolerance.
Gavril Pasternak J Clin Invest.
January 10, 2008
Figure 2. TLR-mediated signals (red arrows) in epithelial cells can induce DC probing of luminal bacteria (1). TLR signaling in epithelial cells (2) and Paneth cells (pink cells; 3) can induce synthesis and luminal release of antimicrobial proteins (red vesicles).
Eric Pamer Nat Immunol.
January 9, 2008
Figure 1. Microscopic pictures of an incidentally detected 2 cm tall-cell variant of papillary thyroid carcinoma (TCVPTC).
Are C, Hsu JF, Ghossein RA, Schoder H, Shah JP, Shaha AR Ann Surg Oncol.
January 8, 2008
Figure 1B. Schematic structures of intramolecular G-quadruplexes formed by the human telomeric sequences: d[AGGG(TTAGGG)3] in a K+-containing crystal.
Phan AT, Kuryavyi V, Luu KN, Patel DJ Nucleic Acids Res.
January 7, 2008
Figure 1. Dr. Elisabeth Pauline Pickett, c. 1975
Yang JH, Donat SM J Urol.
January 4, 2008
Figure 2. Autoradiograms (ARG) and corresponding Oil Red O staining in aortas of ApoE-/- mice injected with 99mTc-annexin A5 (a, b) or 18F-FDG (c, d).
Zhao Y, Kuge Y, Zhao S, Morita K, Inubushi M, Strauss HW, Blankenberg FG, Tamaki N Eur J Nucl Med Mol Imaging.
January 3, 2008
Figure 2A. ZBTB7A IHC analysis showing nuclear immunostaining in very few parabasal intermediate cells (depicted by arrows) of the normal lung epithelium.
Apostolopoulou K, Pateras IS, Evangelou K, Tsantoulis PK, Liontos M, Kittas C, Tiniakos DG, Kotsinas A, Cordon-Cardo C, Gorgoulis VG J Pathol.
January 2, 2008
Figure 1. Schematic of study design.
Shah GD, Yahalom J, Correa DD, Lai RK, Raizer JJ, Schiff D, LaRocca R, Grant B, DeAngelis LM, Abrey LE J Clin Oncol.
Content editor,
Sarah Jewell
Last revised:
July 6, 2008 2:15 PMST
Today's science sparks archives
Today's science sparks archives - January to March 2007
![4D. Triple immunofluorescent merged images (pS6RP [green]/CD31 [red]/DAPI [blue], CD31 [red]]/nestin [green]/DAPI [blue], nestin [green]/pS6RP [red]/DAPI [blue], and nestin [green]/notch receptor [red]/DAPI [blue]) of human medulloblastoma samples showing existence of stem cell niches around blood vessels similar to mouse tumors (n = 2 frozen and 13 paraffin sections, total 15).](http://library.mskcc.org/portal/graphics/sparks/archive/archive2008/GenesDev_hambardzumyan_mini.jpg)
![Fig 4A. Structure of the 10S-(+)-trans-anti-B[a]P-N2-dG adduct n polymerase BF (PDB ID:1XC9).](http://library.mskcc.org/portal/graphics/sparks/archive/archive2008/ChemResTox_Broyde_mini.gif)
![Figure 3E. Structure of the Fbw7 F-box bound to phosphorylated cyclin E C-terminal degron [31].](http://library.mskcc.org/portal/graphics/sparks/archive/archive2008/COCurrBio-Capilli_mini.jpeg)
![Figure 1B. Schematic structures of intramolecular G-quadruplexes formed by the human telomeric sequences: d[AGGG(TTAGGG)3] in a K+-containing crystal.](http://library.mskcc.org/portal/graphics/sparks/archive/archive2008/NucAcidR_Phan_mini.gif)
