Travis WD, Hunninghake G, King TE Jr, Lynch DA, Colby TV, Galvin JR, Brown KK, Chung MP, Cordier JF, du Bois RM, Flaherty KR, Franks TJ, Hansell DM, Hartman TE, Kazerooni EA, Kim DS, Kitaichi M, Koyama T, Martinez FJ, Nagai S, Midthun DE, Müller NL, Nicholson AG, Raghu G, Selman M, Wells A
Am J Respir Crit Care Med. 2008 Jun 15;177(12):1338-47.
June 27, 2008
Fig 1a. merm Mutant Phenotype and Characterization of the merm Allele.
Munbodh R, Jackson A, Bauer J, Schmidtlein CR, Zelefsky MJ
Med Phys. 2008 May;35(5):2137-50.
June 24, 2008
Fig 2e. Active Notch Signaling Initiates Lineage Commitment of hESCs. H9 cells stably transduced with parental or ICNER lentivector were cultured on Matrigel in the absence or presence of 4HT (200 nM) for 6 days. In an independent experiment, 8 day treated cells were stained for Oct4 antibody.
Yu X, Zou J, Ye Z, Hammond H, Chen G, Tokunaga A, Mali P, Li YM, Civin C, Gaiano N, Cheng L.
Cell Stem Cell. 2008 May 8;2(5):461-71.
June 23, 2008
Fig 2a. Effector functions of inflammatory monocytes. While most CCR2+ monocytes are not infected in vivo, monocytes in the peripheal circulation may become infected with L. monocytogenes and transport bacteria to the CNS.
Fig 3b. Dual-color fluorescence in situ hybridization (FISH) on touch preparation sections with a centromeric probe for chromosome 7 (green) in combination with a c-Met-specific probe (red). DAPI (blue) was used as counterstain. Colon cancer with c-Met amplification detected by PCR-LDR, FISH analysis proves the gain in c-Met gene copy number.
Zeng ZS, Weiser MR, Kuntz E, Chen CT, Khan SA, Forslund A, Nash GM, Gimbel M, Yamaguchi Y, Culliford AT 4th, D'Alessio M, Barany F, Paty PB
Cancer Lett. 2008 Jul 8;265(2):258-69.
June 19, 2008
Fig 7a. The HSA domains from yeast modifying complexes RSC (Sth1), SWI-SNF (Snf2), SWR1 (Swr1), NuA4 (Eaf1), INO80 (Ino80) and human SWI-SNF (BRG1) nucleate binding of their respective ARP–ARP or ARP–actin members.
Int J Radiat Oncol Biol Phys. 2008;71(1 Suppl):S152-6.
June 17, 2008
Fig 3A. Endoscopic view of patient with Barrett’s esophagus with high-grade dysplasia before endoscopic mucosal resection using the ”band and snare” technique.
Wakefield BJ, Bylund CL, Holman JE, Ray A, Scherubel M, Kienzle MG, Rosenthal GE
Patient Educ Couns. 2008 May;71(2):285-92.
June 11, 2008
Fig 1B. Bone marrow cytospin from an ML Npm1+/– mouse showing blasts with intracytoplasmic vacuoles, high nuclear/cytoplasmic ratio, basophilic cytoplasm, and multiple nucleoli.
Friedman RJ, Gutkowicz-Krusin D, Farber MJ, Warycha M, Schneider-Kels L, Papastathis N, Mihm MC Jr, Googe P, King R, Prieto VG, Kopf AW, Polsky D, Rabinovitz H, Oliviero M, Cognetta A, Rigel DS, Marghoob A, Rivers J, Johr R, Grant-Kels JM, Tsao H
Arch Dermatol. 2008 Apr;144(4):476-82.
May 29, 2008
Fig 1. Instruments used in the Marian (greater) operation.
Fig 3D. 55-year-old man with newly diagnosed colorectal cancer. Fusion axial PET/CT (D) images from 18F-FDG PET/CT show increased FDG activity within numerous hepatic metastatic lesions (white arrow). Focus of increased activity deep in relation to left latissimus dorsi muscle within fatty-appearing lesion (black arrow) suggests hibernoma.
Matushansky I, Hernando E, Socci ND, Matos T, Mills J, Edgar MA, Schwartz GK, Singer S, Cordon-Cardo C, Maki RG
Am J Pathol. 2008 Apr;172(4):1069-80.
May 20, 2008
Fig 2. Proposed synthesis of C2 oxygenated bridged pyrrolizidine core of the stemofoline alkaloids via inter- or intramolecular dipolar azomethine ylide cycloaddition.
Scope A, Marghoob AA, Dusza SW, Satagopan JM, Agero AL, Benvenuto-Andrade C, Lieb JA, Weinstock MA, Oliveria SA, Geller AC, Halpern AC
Br J Dermatol. 2008 May;158(5):1041-9.
May 15, 2008
Fig 1A. Lethally irradiated BALB/c mice were transplanted with syngeneic purified HS cells (or lin- bone marrow cells); control mice received HS cells only, the treatment group received additional T-cell precursors generated in OP9-DL1 cocultures.
Zakrzewski JL, Suh D, Markley JC, Smith OM, King C, Goldberg GL, Jenq R, Holland AM, Grubin J, Cabrera-Perez J, Brentjens RJ, Lu SX, Rizzuto G, Sant'Angelo DB, Riviere I, Sadelain M, Heller G, Zúñiga-Pflücker JC, Lu C, van den Brink MR
Nat Biotechnol. 2008 Apr;26(4):453-61.
May 14, 2008
Fig 6. A model depicting the relationship of Fos, Jun, and selected kinase signaling pathways to cancer progression in the context of loss of function of Nkx3.1 and Pten.
Scher HI, Halabi S, Tannock I, Morris M, Sternberg CN, Carducci MA, Eisenberger MA, Higano C, Bubley GJ, Dreicer R, Petrylak D, Kantoff P, Basch E, Kelly WK, Figg WD, Small EJ, Beer TM, Wilding G, Martin A, Hussain M; Prostate Cancer Clinical Trials Working Group
Greene MH, Piedmonte M, Alberts D, Gail M, Hensley M, Miner Z, Mai PL, Loud J, Rodriguez G, Basil J, Boggess J, Schwartz PE, Kelley JL, Wakeley KE, Minasian L, Skates S
Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):594-604.
May 5, 2008
Fig 1C-H. Benign spindle-cell GISTs (Case 20 and Case 3) with KIT exon 13 (c) and KIT exon 17 (d) mutations. Malignant spindle-cell GISTs (Case 10 and Case 6) with KIT exon 13 (e) and exon 17 (f) mutations. Malignant epithelioid GISTs (Case 14 and Case 12) with KIT exon 13 (g) and KIT exon 17 (h) mutations.
Lasota J, Corless CL, Heinrich MC, Debiec-Rychter M, Sciot R, Wardelmann E, Merkelbach-Bruse S, Schildhaus HU, Steigen SE, Stachura J, Wozniak A, Antonescu C, Daum O, Martin J, Del Muro JG, Miettinen M
Mod Pathol. 2008 Apr;21(4):476-84.
May 2, 2008
Fig 1. Osteoid osteoma – AP radiograph of the right foot demonstrates sclerosis of the proximal phalanx of the second toe.
Fig 3. Unrooted tree diagramming the relationship between the density-estimated Ramachandran distributions of the four secondary structure classes H (helix), E (sheet), C (coil), and T (turn).
Arthur DW, Winter K, Kuske RR, Bolton J, Rabinovitch R, White J, Hanson WF, Wilenzick RM, McCormick B
Int J Radiat Oncol Biol Phys. 2008 Mar 4 [Epub ahead of print]
April 10, 2008
Fig 2 Bottom. The case was adjudicated as atypical endometrial cells and surgical follow-up revealed an endometrial adenocarcinoma of endometrioid type.
Fig 3A. In wild-type cells, the NHEJ apparatus is assembled at the DSB via contacts between the Ku homodimer (which encircles the DNA as a toroidal clamp) and the POL domain of LigD.
Fig 3. Coronal CT, PET, and integrated PET/CT in 64-year-old man with epithelial malignant pleural mesothelioma show diffuse uptake of [18F]-fluoro-2-deoxy-d-glucose in primary right pleural tumor (SUV 11.6) and focus of increased uptake in 1.5 cm left gastric lymph node (arrow).
Fig 3A. Data from AJ SNPs; The number of SNPs with a positive DA value (excess homozygotes) is graphed above the zero line in each graph. The number of SNPs with a negative DA value is graphed below the zero line in each graph.
Olshen AB, Gold B, Lohmueller KE, Struewing JP, Satagopan J, Stefanov SA, Eskin E, Kirchhoff T, Lautenberger JA, Klein RJ, Friedman E, Norton L, Ellis NA, Viale A, Lee CS, Borgen PI, Clark AG, Offit K, Boyd J
BMC Genet. 2008 Feb 5;9:14.
April 3, 2008
Fig 1B. Modeling cell mechanics as an energy minimization problem; Schematic of a hypothetical energy landscape representing varying combinations of two parameters.
Today's science sparks archives
Today's science sparks archives - April to June 2008
![Fig 3. Coronal CT, PET, and integrated PET/CT in 64-year-old man with epithelial malignant pleural mesothelioma show diffuse uptake of [18F]-fluoro-2-deoxy-d-glucose in primary right pleural tumor (SUV 11.6) and focus of increased uptake in 1.5 cm left gastric lymph node (arrow).](http://library.mskcc.org/portal/graphics/sparks/archive/archive2008/LungCancer_Armato_mini.jpg)
