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Home Today's science sparks archives
 Today's science sparks archives - April to June 2007

Today's science sparks archives - April to June 2007

This page contains images and links to articles previously featured.

June 28, 2007

Fig 1. Classes of genes participating in the metastasis process.

Fig 1. Classes of genes participating in the metastasis process.
    Nguyen DX, Massagué J

  • Nat Rev Genet.
    2007 May;8(5):341-52

June 27, 2007

Fig 1. Six patients received a metallic prosthesis, as shown here.

Fig 1. Six patients received a metallic prosthesis, as shown here.
    Behnam AB, Chen CM, Pusic AL, Mehrara BJ, Disa JJ, Athanasian EA, Cordeiro PG

  • Ann Surg Oncol.
    2007 May;14(5):1591-5.

June 25, 2007

Fig 3B. Interaction Surfaces on Sec23/24 and Sec22; Picture shows interactions between the Sec22 longin domain (pink) and Sec24 (blue).

Fig 3B. Interaction Surfaces on Sec23/24 and Sec22; Picture shows interactions between the Sec22 longin domain (pink) and Sec24 (blue).
    Mancias JD, Goldberg J

  • Mol Cell.
    2007 May 11;26(3):403-14.

June 22, 2007

Fig 1. The Superior Vena Cava Syndrome.

Fig 1. The Superior Vena Cava Syndrome.
    Wilson LD, Detterbeck FC, Yahalom J

  • N Engl J Med.
    2007 May 3;356(18):1862-9.

June 21, 2007

Fig 5. Proposed model for the role of LRF in determining B versus T lineage fate.

Fig 5. Proposed model for the role of LRF in determining B versus T lineage fate.
    Maeda T, Merghoub T, Hobbs RM, Dong L, Maeda M, Zakrzewski J, van den Brink MR, Zelent A, Shigematsu H, Akashi K, Teruya-Feldstein J, Cattoretti G, Pandolfi PP

  • Science.
    2007 May 11;316(5826):860-6.

June 20, 2007

Fig 1. Example Data Entry Screen.

Fig 1. Example Data Entry Screen.
    Basch E, Artz D, Iasonos A, Speakman J, Shannon K, Lin K, Pun C, Yong H, Fearn P, Barz A, Scher HI, McCabe M, Schrag D

  • J Am Med Inform Assoc.
    2007 May-Jun;14(3):264-8.

June 19, 2007

Fig 1. HIP1 expression in brain tumor tissue.

Fig 1. HIP1 expression in brain tumor tissue.
    Bradley SV, Holland EC, Liu GY, Thomas D, Hyun TS, Ross TS

  • Cancer Res.
    2007 Apr 15;67(8):3609-15.

June 18, 2007

Fig 1. Schematic of prostate gland depicts zonal anatomy.

Fig 1. Schematic of prostate gland depicts zonal anatomy.
    Curran S, Akin O, Agildere AM, Zhang J, Hricak H, Rademaker J

  • AJR Am J Roentgenol.
    2007 May;188(5):1373-9.

June 15, 2007

Fig 3A. Transaxial contrast-enhanced CT image of 51-y-old woman with calcitonin level of 48,800 pg/mL shows hepatic metastasis (arrow).

Fig 3A. Transaxial contrast-enhanced CT image of 51-y-old woman with calcitonin level of 48,800 pg/mL shows hepatic metastasis (arrow).
    Ong SC, Schöder H, Patel SG, Tabangay-Lim IM, Doddamane I, Gönen M, Shaha AR, Tuttle RM, Shah JP, Larson SM

  • J Nucl Med.
    2007 Apr;48(4):501-7.

June 14, 2007

Fig 1. Immunohistochemical analysis of erbB2, VCAM, H-ras, and MDM2 in head and neck squamous cell carcinoma tumors.

Fig 1. Immunohistochemical analysis of erbB2, VCAM, H-ras, and MDM2 in head and neck squamous cell carcinoma tumors.
    Ganly I, Talbot S, Carlson D, Viale A, Maghami E, Osman I, Sherman E, Pfister D, Chuai S, Shaha AR, Kraus D, Shah JP, Socci ND, Singh B

  • J Clin Oncol.
    2007 Apr 10;25(11):1369-76.

June 13, 2007

Fig 4. Mucin-related tumour-associated carbohydrate antigens.

Fig 4. Mucin-related tumour-associated carbohydrate antigens.
    Galonicá DP, Gin DY

  • Nature.
    2007 Apr 26;446(7139):1000-7.

June 12, 2007

Fig 1. CTC cytopathologic analysis. Immunomagnetically isolated CTCs stained by the Papanicolau method are shown under high power (top). Cells destained, then stained by immunocytochemistry for cytokeratins (CK) or α-methyl CoA-racemase (AMACR), a specific marker of prostate cancer cells (bottom).

Fig 1. CTC cytopathologic analysis. Immunomagnetically isolated CTCs stained by the Papanicolau method are shown under high power (top). Cells destained, then stained by immunocytochemistry for cytokeratins (CK) or α-methyl CoA-racemase (AMACR), a specific marker of prostate cancer cells (bottom).
    Shaffer DR, Leversha MA, Danila DC, Lin O, Gonzalez-Espinoza R, Gu B, Anand A, Smith K, Maslak P, Doyle GV, Terstappen LW, Lilja H, Heller G, Fleisher M, Scher HI

  • Clin Cancer Res.
    2007 Apr 1;13(7):2023-9.

June 8, 2007

Fig 1B(R). Space-filling models of the human Lig1 protein are shown with DNA in the cavity.

Fig 1B(R). Space-filling models of the human Lig1 protein are shown with DNA in the cavity.
    Nandakumar J, Nair PA, Shuman S

  • Mol Cell.
    2007 Apr 27;26(2):257-71.

June 7, 2007

Fig 3. Comparison of early mitotic defects in PLK1-null and Plk1as cells.

Fig 3. Comparison of early mitotic defects in PLK1-null and Plk1as cells.
    Burkard ME, Randall CL, Larochelle S, Zhang C, Shokat KM, Fisher RP, Jallepalli PV

  • Proc Natl Acad Sci U S A.
    2007 Mar 13;104(11):4383-8.

June 6, 2007

Fig 2. Minimum distance from cancer to urethra (mm).

Fig 2. Minimum distance from cancer to urethra (mm).
    Huang WC, Kuroiwa K, Serio AM, Bianco FJ, Fine SW, Shayegan B, Scardino PT, Eastham JA

  • J Urol.
    2007 Apr;177(4):1324-9.

June 5, 2007

Fig 1.Molecular organization of the checkpoint signaling network in response to DNA DSBs and replicative stress.

Fig 1.Molecular organization of the checkpoint signaling network in response to DNA DSBs and replicative stress.
    Tse AN, Carvajal R, Schwartz GK

  • Clin Cancer Res.
    2007 Apr 1;13(7):1955-60.

June 4, 2007

Fig 2D. Structure of the human A-site RNA...Interactions of the C1409·A1492 base pair.

Fig 2D. Structure of the human A-site RNA...Interactions of the C1409·A1492 base pair.
    Hermann T, Tereshko V, Skripkin E, Patel DJ

  • Blood Cells Mol Dis.
    2007 May-Jun;38(3):193-8.

June 1, 2007

Fig 1. Low-power image of botryoid embryonal RMS with polypoid architecture, characteristic cambium layer, and myxoid stroma.

Fig 1. Low-power image of botryoid embryonal RMS with polypoid architecture, characteristic cambium layer, and myxoid stroma.
    Ferguson SE, Gerald W, Barakat RR, Chi DS, Soslow RA

  • Am J Surg Pathol.
    2007 Mar;31(3):382-9.

May 31, 2007

Fig 1. Role of the glutathione pathway and ABC-transporter family in drug elimination and defense from ROS-mediated oxidative stress.

Fig 1. Role of the glutathione pathway and ABC-transporter family in drug elimination and defense from ROS-mediated oxidative stress.
    Andreadis C, Gimotty PA, Wahl P, Hammond R, Houldsworth J, Schuster SJ, Rebbeck TR

  • Blood.
    2007 Apr 15;109(8):3409-16

May 30, 2007

Fig 7A. Clinical image revealing pseudo-Hutchinson's sign that results from pigment in matrix becoming visible through relatively translucent cuticule.

Fig 7A. Clinical image revealing pseudo-Hutchinson's sign that results from pigment in matrix becoming visible through relatively translucent cuticule.
    Braun RP, Baran R, Le Gal FA, Dalle S, Ronger S, Pandolfi R, Gaide O, French LE, Laugier P, Saurat JH, Marghoob AA, Thomas L

  • J Am Acad Dermatol.
    2007 May;56(5):835-47

May 29, 2007

Fig 5A. View into the minor groove of superpositioned intensity-refined structures of the G6*G7 sequence contexts at the 12-mer duplex level.

Fig 5A. View into the minor groove of superpositioned intensity-refined structures of the G6*G7 sequence contexts at the 12-mer duplex level.
    Rodriguez FA, Cai Y, Lin C, Tang Y, Kolbanovskiy A, Amin S, Patel DJ, Broyde S, Geacintov NE

  • Nucleic Acids Res.
    2007;35(5):1555-68.

May 25, 2007

Fig 4A. Schematic representation of the time course for tumour cell implantation, primary tumour growth and therapeutic treatment to assess effects on primary tumour and lung metastatic progression.

Fig 4A. Schematic representation of the time course for tumour cell implantation, primary tumour growth and therapeutic treatment to assess effects on primary tumour and lung metastatic progression.
    Gupta GP, Nguyen DX, Chiang AC, Bos PD, Kim JY, Nadal C, Gomis RR, Manova-Todorova K, Massague J

  • Nature.
    2007 Apr 12;446(7137):765-70.

May 24, 2007

Fig 1C. Image fusion of the simulation computed tomography (CT) scan and megavoltage cone-beam computed tomography (MV CBCT) scan...

Fig 1C. Image fusion of the simulation computed tomography (CT) scan and megavoltage cone-beam computed tomography (MV CBCT) scan...
    Chang J, Mageras GS, Yorke E, De Arruda F, Sillanpaa J, Rosenzweig KE, Hertanto A, Pham H, Seppi E, Pevsner A, Ling CC, Amols H

  • Int J Radiat Oncol Biol Phys.
    2007 Apr 1;67(5):1548-58.

May 23, 2007

Fig 7. Placement of the Ubiquitylation Sites in the RNAPII Structure and a Model for the Mechanism of RNAPII Ubiquitylation.

Fig 7. Placement of the Ubiquitylation Sites in the RNAPII Structure and a Model for the Mechanism of RNAPII Ubiquitylation.
    Somesh BP, Sigurdsson S, Saeki H, Erdjument-Bromage H, Tempst P, Svejstrup JQ

  • Cell.
    2007 Apr 6;129(1):57-68.

May 21, 2007

Fig 2. Thermoplastic mask system extending from vertex of scalp to shoulder aids in immobilization of the patient.

Fig 2. Thermoplastic mask system extending from vertex of scalp to shoulder aids in immobilization of the patient.
    Lee N, Puri DR, Blanco AI, Chao KS

  • Head Neck.
    2007 Apr;29(4):387-400.

May 18, 2007

Fig 2. Axial radiation isodose distribution for a single 12 MeV electron field.

Fig 2. Axial radiation isodose distribution for a single 12 MeV electron field.
    S Hausmann, A Ramirez, S Schneider, B Schwer, S Shuman

  • Neurosurgery.
    2007 Apr;60(4):E782; discussion E782.

May 17, 2007

Fig 7. Cap guanine-N7 methyltransferase is essential in S. pombe.

Fig 7. Cap guanine-N7 methyltransferase is essential in S. pombe.
    Hoffman CE, Lis E, Wolden SL, Souweidane MM

  • Nucleic Acids Research.
    2007;Vol 35 (5): 1411-1420.

May 16, 2007

Fig 11c: Surgically confirmed Gleason score 8 adenocarcinoma.

Fig 11c. Surgically confirmed Gleason score 8 adenocarcinoma.
    Hricak H, Choyke PL, Eberhardt SC, Leibel SA, Scardino PT

  • Radiology.
    2007 Apr;243(1):28-53.

May 15, 2007

Fig 7. Dual role of Rho GTPases and PRK2 during mitosis.

Fig 7. Dual role of Rho GTPases and PRK2 during mitosis.
    Schmidt A, Durgan J, Magalhaes A, Hall A

  • EMBO J.
    2007 Mar 21;26(6):1624-36

May 14, 2007

Fig 2A. Combined Results for the Studies of Lung Cancer Screening With Computed Tomography.

Fig 2A. Combined Results for the Studies of Lung Cancer Screening With Computed Tomography.
    Bach PB, Jett JR, Pastorino U, Tockman MS, Swensen SJ, Begg CB

  • JAMA.
    2007 Mar 7;297(9):953-61.

May 11, 2007

Fig 4b. Mapping of polymorphic residues on Tim-3.

Fig 4b. Mapping of polymorphic residues on Tim-3.
  • Cao E, Zang X, Ramagopal UA, Mukhopadhaya A, Fedorov A, Fedorov E, Zencheck WD, Lary JW, Cole JL, Deng H, Xiao H, Dilorenzo TP, Allison JP, Nathenson SG, Almo SC

  • Immunity.
    2007 Mar;26(3):311-21.

May 10, 2007

Fig 1A. The transgene is expressed in all lineages from a vector encoding an ubiquitous promoter.

Fig 1A. The transgene is expressed in all lineages from a vector encoding an ubiquitous promoter.
  • Chang AH, Sadelain M

  • Mol Ther.
    2007 Mar;15(3):445-56

May 9, 2007

Fig 1. Attitudes in surgery can tilt the balance of training toward more favorable or less favorable directions.

Fig 1. Attitudes in surgery can tilt the balance of training toward more favorable or less favorable directions.
  • Itani KM, Morris PJ, Macias FC, Bevilacqua RG, Cheng SW, Ladipo JK, Brennan MF

  • J Am Coll Surg.
    2007 Mar;204(3):478-85.

May 8, 2007

Fig 2B. Histologic section of a retroperitoneal mass showing the characteristic LAM cell proliferation.

Fig 2B. Histologic section of a retroperitoneal mass showing the characteristic LAM cell proliferation.
  • Kebria M, Black D, Borelli C, Modica I, Hensley M, Chi DS

  • Int J Gynecol Cancer.
    2007 Mar-Apr;17(2):528-32.

May 7, 2007

Fig 8. Models for splicing regulation of MCAD exon 5 (A–D), SMN1/2 exon 7 (E and F), and HC5 exon 10 (G and H).

Fig 8. Models for splicing regulation of MCAD exon 5 (A–D), SMN1/2 exon 7 (E and F), and HC5 exon 10 (G and H).
  • Nielsen KB, Sorensen S, Cartegni L, Corydon TJ, Doktor TK, Schroeder LD, Reinert LS, Elpeleg O, Krainer AR, Gregersen N, Kjems J, Andresen BS

  • Am J Hum Genet.
    2007 Mar;80(3):416-32.

May 4, 2007

Fig 1. Dr. Hunter H. McGuire (c. 1887).

Fig 1. Dr. Hunter H. McGuire (c. 1887).
  • Herr HW

  • J Urol.
    2007 Apr;177(4):1250-3.

May 2, 2007

Fig 7. Schematics of the dermoscopic findings in solitary angiokeratomas.

Fig 7. Schematics of the dermoscopic findings in solitary angiokeratomas.
  • Zaballos P, Daufi C, Puig S, Argenziano G, Moreno-Ramirez D, Cabo H, Marghoob AA, Llambrich A, Zalaudek I, Malvehy J

  • Arch Dermatol.
    2007 Mar;143(3):318-25.

May 1, 2007

Fig 2. Stability of Physician Assignments of Medicare Beneficiaries from 2000 through 2002.

Fig 2. Stability of Physician Assignments of Medicare Beneficiaries from 2000 through 2002.
  • Pham HH, Schrag D, O'Malley AS, Wu B, Bach PB

  • N Engl J Med.
    2007 Mar 15;356(11):1130-9.

April 30, 2007

Fig 1E. Cellular composition of ES-derived and hippocampal cultures.

Fig 1E. Cellular composition of ES-derived and hippocampal cultures.
  • Ban J, Bonifazi P, Pinato G, Broccard FD, Studer L, Torre V, Ruaro ME

  • Stem Cells.
    2007 Mar;25(3):738-49.

April 27, 2007

Fig 3. Radiographs of a 6-year-old boy with a history of Ewing’s sarcoma of the left proximal femur who underwent free fibula osteocutaneous flap for salvage of failed allograft reconstruction.

Fig 3. Radiographs of a 6-year-old boy with a history of Ewing’s sarcoma of the left proximal femur who underwent free fibula osteocutaneous flap for salvage of failed allograft reconstruction.
  • Chen CM, Disa JJ, Lee HY, Mehrara BJ, Hu QY, Nathan S, Boland P, Healey J, Cordeiro PG

  • Plast Reconstr Surg.
    2007 Mar;119(3):915-24

April 26, 2007

Fig 2A. Typical HEp-2 cell IFA staining patterns of antibodies cloned from IgG+ memory B cells are shown.

Fig 2A. Typical HEp-2 cell IFA staining patterns of antibodies cloned from IgG+ memory B cells are shown.
  • Tiller T, Tsuiji M, Yurasov S, Velinzon K, Nussenzweig MC, Wardemann H

  • Immunity.
    2007 Feb;26(2):205-13.

April 25, 2007

Fig 1. Percentage of oncologists recommending adjuvant chemotherapy for older patients with high-risk, node-positive, and hormone-receptor-negative breast cancer.

Fig 1. Percentage of oncologists recommending adjuvant chemotherapy for older patients with high-risk, node-positive, and hormone-receptor-negative breast cancer.
  • Hurria A, Naeim A, Elkin E, Limaye S, Grover A, Hudis C, Pearce C, Robson M

  • Crit Rev Oncol Hematol.
    2007 Mar;61(3):255-60.

April 24, 2007

Fig 1E. SC Assembly Defects in Prophase Meiocytes from Mre11 Complex Hypomorphic Mice

Fig 1E. SC Assembly Defects in Prophase Meiocytes from Mre11 Complex Hypomorphic Mice
  • Cherry SM, Adelman CA, Theunissen JW, Hassold TJ, Hunt PA, Petrini JH

  • Curr Biol.
    2007 Feb 20;17(4):373-8.

April 23, 2007

Fig 1B. The

Fig 1B. The "wiring" diagram of CoSMO.
  • Shou W, Ram S, Vilar JM

  • Proc Natl Acad Sci U S A.
    2007 Feb 6;104(6):1877-82.

April 20, 2007

Fig 1b. Diffusion tensor imaging (DTI) is a recently developed technique...

Fig 1b. Diffusion tensor imaging (DTI) is a recently developed technique...
  • Ahles TA, Saykin AJ

  • Nat Rev Cancer.
    2007 Mar;7(3):192-201.

April 19, 2007

Fig 1. TILs and expression of MHC class I antigen in representative UC tumor samples.

Fig 1. TILs and expression of MHC class I antigen in representative UC tumor samples.
  • Sharma P, Shen Y, Wen S, Yamada S, Jungbluth AA, Gnjatic S, Bajorin DF, Reuter VE, Herr H, Old LJ, Sato E

  • Proc Natl Acad Sci U S A.
    2007 Mar 6;104(10):3967-72.

April 18, 2007

Fig 1. Identification of WTX deletions in Wilms tumor.

Fig 1. Identification of WTX deletions in Wilms tumor.
  • Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO, Chin L, Iafrate AJ, Bell DW, Haber DA

  • Science.
    2007 Feb 2;315(5812):642-5.

April 17, 2007

Fig 4. MET expression and activation of downstream signaling in tumors with TFE3 fusions and its inhibition by RNA interference and PHA665752.

Fig 4. MET expression and activation of downstream signaling in tumors with TFE3 fusions and its inhibition by RNA interference and PHA665752.
  • Tsuda M, Davis IJ, Argani P, Shukla N, McGill GG, Nagai M, Saito T, Laé M, Fisher DE, Ladanyi M

  • Cancer Res.
    2007 Feb 1;67(3):919-29.

April 16, 2007

Fig 2. The pre-metastatic niche.

Fig 2. The pre-metastatic niche.
  • Kaplan RN, Psaila B, Lyden D

  • Trends Mol Med
    2007 Feb;13(2):72-81.

April 13, 2007

Breast cancer cells can spread to other parts of the body

Breast cancer cells can spread to other parts of the body
  • Based on research by
    Gaorav Gupta, Joan Massague, et al

  • BBC News
    April 12, 2007
    http://www.bbc.co.uk

April 12, 2007

Fig 1D. Histochemical detection of senescence-associated ß-galactosidase activity (SA-β-gal; stained at pH 6.0) and lysosomal, non–senescence-associated β-galactosidase activity (adjacent sections stained at pH 4.0).

Fig 1D. Histochemical detection of senescence-associated ß-galactosidase activity (SA-β-gal; stained at pH 6.0) and lysosomal, non–senescence-associated β-galactosidase activity (adjacent sections stained at pH 4.0).
  • Mo L, Zheng X, Huang HY, Shapiro E, Lepor H, Cordon-Cardo C, Sun TT, Wu XR

  • J Clin Invest.
    2007 Feb;117(2):314-25.

April 11, 2007

Fig 1. Representative examples of methylation-specific polymerase chain reaction for genes CDKN2A (analyzed separately as p14 and p16), DAPK1, CDH1 (alias E-CAD), and ADAM23.

Fig 1. Representative examples of methylation-specific polymerase chain reaction for genes CDKN2A (analyzed separately as p14 and p16), DAPK1, CDH1 (alias E-CAD), and ADAM23.
  • Calmon MF, Colombo J, Carvalho F, Souza FP, Filho JF, Fukuyama EE, Camargo AA, Caballero OL, Tajara EH, Cordeiro JA, Rahal P

  • Cancer Genet Cytogenet.
    2007 Feb;173(1):31-7.

April 10, 2007

Fig 1. Drosophila frataxin protein (FH) localizes in the mitochondria.

Fig 1. Drosophila frataxin protein (FH) localizes in the mitochondria.
  • Llorens JV, Navarro JA, Martinez-Sebastian MJ, Baylies MK, Schneuwly S, Botella JA, Molto MD

  • FASEB J.
    2007 Feb;21(2):333-44.

April 9, 2007

Fig 1. Dysplastic nevus in case 1.

Fig 1. Dysplastic nevus in case 1.
  • Scope A, Benvenuto-Andrade C, Agero AL, Halpern AC, Gonzalez S, Marghoob AA

  • Arch Dermatol.
    2007 Feb;143(2):176-85.

April 5, 2007

Fig 2. Pimonidazole (green) and CAIX (red) staining relative to perfused vessels (blue) in a control tumor.

Fig 2. Pimonidazole (green) and CAIX (red) staining relative to perfused vessels (blue) in a control tumor.
  • Shin KH, Diaz-Gonzalez JA, Russell J, Chen Q, Burgman P, Li XF, Ling CC

  • Cancer Biol Ther.
    2007 Jan 29;6(1)
    [Epub ahead of print]

April 4, 2007

Fig 2. Protein Profiling for Cancer Diagnosis and Prognosis.

Fig 2. Protein Profiling for Cancer Diagnosis and Prognosis.
  • Mathew JP, Taylor BS, Bader GD, Pyarajan S, Antoniotti M, Chinnaiyan AM, Sander C, Burakoff SJ, Mishra B

  • PLoS Comput Biol.
    2007 Feb 23;3(2):e12.

April 3, 2007

Fig 3B. Knockdown of Nek3 attenuates PRL-mediated cytoskeletal re-organization of T47D but not MDA-MB231 breast cancer cells.

Fig 3B. Knockdown of Nek3 attenuates PRL-mediated cytoskeletal re-organization of T47D but not MDA-MB231 breast cancer cells.
  • Miller SL, Antico G, Raghunath PN, Tomaszewski JE, Clevenger CV

  • Oncogene.
    2007 Feb 12; [Epub ahead of print]

April 2, 2007

Fig 1C. Localization and size of the C2 loop within the PTEN structure (single amino acid code over backbone).

Fig 1C. Localization and size of the C2 loop within the PTEN structure (single amino acid code over backbone).
  • Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, Tempst P, Chi SG, Kim HJ, Misteli T, Jiang X, Pandolfi PP

  • Cell.
    2007 Jan 12;128(1):141-56.
Content editor, Sarah Jewell
Last revised:July 6, 2008 2:23 PM EST
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